Film-forming formulations represent a novel form of sustained release dermatic products.用于皮肤液化或半固化编程通过皮肤挥发溶剂蒸发,配方内含聚合物组成固膜各种胶片配方测试水阻抗并作比较 [.]
Der Betrag Film-forming formulations represent a novel form of sustained release dermatic products.用于皮肤液化或半固化编程通过皮肤挥发溶剂蒸发,配方内含聚合物组成固膜各种胶片配方测试水阻和压强并比对传统半固化配方渗透渗透研究显示半转基因治疗系统有潜在实用性可替代补丁系统以切题方式管理各种药物并持续发布特征。
Polymers for use in film-forming formulations
| Polymer | Properties |
|---|---|
| Carbopol (polyacrylat) | water-soluble, pH sensitive |
| Chitosan (Poly-D-Glucosamin) | water-soluble at pH < 7 |
| Crosslinked polymer layer XPL | adhesive, elastic |
| Dermacryl 79 (Carboxylates Acrylpolymer) | water-insoluble |
| Ethylcellulose | non-toxic, not irritating, anti-allergic |
| Eudragit NE (ethylacrylate methylmethacrylate copolymer) | water-insoluble, transparent, elastic, adhesive |
| Eudragit RL-100 (polymethacrylate polymere) | water-insoluble, transparent, elastic, adhesive |
| Eudragit RS-100 (polymethacrylate polymere) | water-insoluble, transparent, elastic, adhesive |
| Eudragit L30D-55 (methacrylate-ethylacrylate-copolymer) | water dispersible at pH 2–3 |
| Hydroxypropyl-beta-cyclodextrin | water-insoluble, increases bioavailability |
| Hydroxypropylmethylcellulose (HPMC) | water-soluble, non-ionic |
| KIucel (Hydroxypropyl cellulose) | water-soluble, non-ionic |
| Macrogol | water-soluble |
| Methyl cellulose | water-soluble |
| Poloxamer (polyethylenepolypropylene glycol) | thermoreversible |
| Plastoid (Butyl methacrylate-methylmethacrylate copolymer) | water-insoluble |
| Polydimethylsiloxane (PDMS) | water-insoluble, non-toxic |
| Polyvinyl alcohol (PVA) | water-soluble, adhesive, non-toxic |
| Polyvinyl pyrrolidine (PVP) | water-soluble, adhesive, increase bioavailability |
| Quaternary polymethacrylat (QPM) | water-insoluble |
| Sepineo P600 (acrylamide/sodium acryloldimethyltaurate) | water-insoluble |
| Silicone | water-soluble, non-occlusive |
Conclusions and Further Prospects
The incorporation of 3D printing technologies in the pharmaceutical industry can revolutionize its R&D, by providing a simple and rapid method to produce tailored one-off batches, each with customized dosages, different compounds, shapes, sizes, and adjusted release rates.具体地说,这类技术可有利于开发热点和跨面药提供系统,包括 [.]
Der Beitrag The incorporation of 3D printing technologies in the pharmaceutical industry can revolutionize its R&D, by providing a simple and rapid method to produce tailored one-off batches, each with customized dosages, different compounds, shapes, sizes, and adjusted release rates.具体地说,这类技术可有利于开发专题和跨式药物提供系统,包括补丁和微软码片。
最近数项研究被选择支持本文所探讨主题的相关性并讨论这些打印技术的局限性,包括规范、质量和安全问题。
The objective was to develop a reservoir-type nimesulide gel patch for controlled drug delivery and avoid the gastrointestinal adverse effects associated with the oral delivery of nimesulide.六大补丁化凝胶配方,包括乙醇20-40%和渗透增强器丙烯甘醇20-40%卡波尔934系统被用作凝胶 [.]
Der Betrag
The objective was to develop a reservoir-type nimesulide gel patch for controlled drug delivery and avoid the gastrointestinal adverse effects associated with the oral delivery of nimesulide.六大补丁化凝胶配方,包括乙醇20-40%和渗透增强器丙烯甘醇20-40%s/www.pharmaex接受者.com/product/carbopol-934-nf-聚合物/水库跨模补丁填充凝胶体外释放和皮肤渗透使用USP设备V.
评估优化配方表面积减为1cmsup2 F3配方由40%乙醇和20%丙烯甘醇组成被认为优化,原因是最大释放量(86.3+2.73%)和渗透量(3048.84+17.23g/cmsup2 ),通量为449.92g/cmsup2 2misulide凝胶水库式跨模补丁有潜力以受控释放方式传递药物。ahrefss/link.springer.com/article/10.1007/s0027/03764-0'目标='blank'rel=nopener'>Bull. (2021).https://doi.org/10.1007/s00289-021-03764-0
Der Beitrag Formulation development and evaluation of nimesulide transdermal gel patch system erschien zuerst auf Pharma Excipients.
An efficacious topical treatment for cutaneous leishmaniasis (CL) is highly desirable but still an ongoing challenge.系统立体特征报告并显示Eudragit EPO异常区域学这项工作的目的是调查时事Ris和ss/skin-droate-eudragit-leishmanpat-service-e
An efficacious topical treatment for cutaneous leishmaniasis (CL) is highly desirable but still an ongoing challenge.系统立体属性报告 Beitrag
This research aimed to develop a novel drug delivery system to improve treatment of skin disorders.系统由 Carbopol980基纳米模0.05%, w/w)纳米化,小粒度高,封装效率高,热动稳定,渗透能力高,皮肤保留高DES-loadedNE [.]
DerBeitrag This research aimed to develop a novel drug delivery system to improve treatment of skin disorders.系统由 DES体外释放和皮肤渗透研究用人工膜和鼠腹皮的不同配方用弗朗兹扩散细胞系统完成封装激光扫描显微镜用于检测药物皮肤定位和渗透路径与商业可用gel和NE相比,NEGel释放过程符合Higuchi发布模型( R 2 =0.9813)。NE和NE-Gel累计渗透12He值分别为63.13+2.78和42.53+2.06g/cmsup2 p < 0.01)。编译NE-Gel是改善专题DES交付以更好地处理皮肤失常的潜在工具。 Der Beitrag Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization erschien zuerst auf Pharma Excipients.
The aim of the present study was to develop, optimize brucine-loaded transliposomes (BRC-TL) formulation for dermal delivery of brucine for skin cancer.BRC-TL配方评价卷积大小、绑定效率以及体外药物释放优化配方通过组合激光显微镜和皮肤变换研究进一步评价皮肤渗透sp>Der Beltrag
The aim of the present study was to develop, optimize brucine-loaded transliposomes (BRC-TL) formulation for dermal delivery of brucine for skin cancer.BRC-TL配方评价卷积大小、绑定效率以及体外药物释放优化配方通过卷式激光显微镜和皮肤学研究进一步评价皮肤渗透问题。
优化BRC-TL配方显示密封单片卷子,单片尺寸、多差指数、套接率和体外药物释放量分别为136.20+2.87Nm、0.354+0.02、8601+1.27%和83.09+2.07%Ex Vivo渗透研究表明,开发BRC-TL配方渗透比BRC悬浮增加2.4倍纹理分析显示BRC-TL凝固度为158.91g,一致性为615.03g/s,内聚度-115.26g和粘度指数-472.05g/s鼠皮合影清晰显示rodamibB加载TL配方比rodamibBHIL解法深入渗透度。BRC-TL处理鼠皮肤显示Csub>skin最大 和AUC 0-8 与BRC常规gel处理鼠皮肤相比大幅增加数据显示,开发TLs配方可成为处理皮肤癌时布丁热投送有希望的药纳米机。
ahrfss/link.springer.com/article/10.1007s13305-021-5'目标https://doi.org/10.1007/S13205-0210841-5/p>Der Beitrag
Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries.科学家们同时对大麻相关研究工作重新表示兴趣多年来,临床和前科研究显示,大麻素对各种指针的治疗意义[.]
Der Beitrag
Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries.科学家们同时对大麻相关研究工作重新表示兴趣多年来,临床和前科研究显示,大麻素对各种指针的治疗意义此外,正在努力开发大麻相关产品成可接受的处方产品FDA授权商业使用四种大麻素衍生产品,口服剂量表已经是一项重大进步。
其中包括肝退化导致口服生物利用率低、气分不稳、水溶性差,以及高剂量使用与该药高等离子富集相关联的精神药物大麻素所经历的副作用但这些都可限制并配之以传递毒药新兴时序策略可成功开发高效大麻素传输系统本审查讨论通过皮肤提供治疗性大麻素的可行性,并综合描述文献迄今报告的支持性研究Continue on cannabinoids skin delivery
Akeemat O.Tijani、Divya Thakur、Dhruv Mishra、Dorcas FrempongChukwunyere,AshanaPuri,br/>通过皮肤提供治疗性大麻素:当前状态和未来前景,br/>控制释放杂志3342021卷427-451,br/>https://doi.org/101016/j.jconrel.20210.05.
During the past two decades, the clinical use of biopharmaceutical products has markedly increased because of their obvious advantages over conventional small-molecule drug products.这些优势包括提高特性、能力、目标选择能力并减少副作用大型分子结构以及生物药理学内在不稳定化编程和 [.]
DerBeitrag During the past two decades, the clinical use of biopharmaceutical products has markedly increased because of their obvious advantages over conventional small-molecule drug products.这些优势包括提高特性、能力、目标选择能力并减少副作用大型分子结构及生物药厂固有不稳定性尽管在临床和商业上大都取得了成功,但它们的配方和管理挑战并成为唯一可行的选择。 使用纳米机高效投送生物药厂至关重要,因为它们有实用利益,如保护避免恶意生理环境退化,提高等离子半衰期和保留时间,便利通过寄生虫吸收,提供网站专用投送,改善细胞内目标获取在当前审查中,我们强调生物药理学的临床和商业成功性以及纳米机在生物药理提供方面的总体应用和潜力。提交数据无疑显示纳米载体与生物药理结合的巨大潜力,在今后临床全景中改善保健产品纳米载体为荷尔蒙、Cytokines、核酸、疫苗、抗体、酶和基于基因和细胞治疗多病症提供极有希望工具。
Der Beitrag Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals erschien zuerst auf Pharma Excipients.
In the present study, combinatorial nanostructured lipid carrier gel of 5-fluorouracil and resveratrol was formulated, optimized and characterized to enhance permeation in between epidermis and dermis layers of the skin to obtain a synergistic effect against skin cancer.广度测试后开发出新修改的emulsiocation法,并首次开发稳定性 [.]
Der Beitrag In the present study, combinatorial nanostructured lipid carrier gel of 5-fluorouracil and resveratrol was formulated, optimized and characterized to enhance permeation in between epidermis and dermis layers of the skin to obtain a synergistic effect against skin cancer.广度测试后开发出新修改的emulsiocation法,并首次开始稳定化研究优化配方技术,同时显示两个主要效果first, it provided best-optimized technique for preparation of combinatorial lipid-nanosystem, and secondly, it also demonstrated a detailed report card of durability of formulations. For the preparation of a stable dual drug-loaded lipid-nanosystem of 5-FU and RSV, a modified emulsiosonication method has been developed and optimized. The slow and prolonged release of 5-FU and RSV from the combinatorial lipid-nanosystem reduced the systemic absorption and maximized the drug retention in between epidermis and dermis for the management and treatment of skin cancer. In vitro, ex vivo permeation analysis and mechanism of skin permeation enhancement study revealed the enhanced permeation via alteration in the tight junction of stratum corneum. Dermatokinetic assessment and depth analysis studies confirmed that the combinatorial lipid-nanosystem was much more efficient than conventional formulation in dermal application. In vitro efficacy study also showed a greater efficacy of linogel over the conventional formulation. In vitro release study showed a significantly improved, slow and prolonged release of drugs from the optimized lipid-nanosystem (***p<0.05), which followed non-Fickian Higuchi kinetics.此外,皮肤渗透增强机制、皮肤变异学评估以及对皮肤优化配方的深度分析显示渗透性提高和药流流至皮肤皮层组合linogel比常规配方高得多(+em>p/em>0.01)。检测结果显示,经修改的双重药用脂质系统准备法导致生成稳定配方,并改进5-氟聚CLLLLRizvi、Madan Mohan Gupta、Javed阿里、Sanjula Baboota2021年欧洲药理学和生物药理学杂志https://doi.org/101016/j.ejpb2021.04.007.. Der Beitrag
Highlights
Parkinson's disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer's disease.此外,老年人口的风险发生率较高。主要的PD特征包括多聚胺神经元损失和Lewy机体开发s/psss/nanopatics-antiparkinsoian-dogs/
Parkinson's disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer's disease.此外,老年人口的风险发生率较高。主要的PD特征包括多聚胺神经元损失和Lewy机体开发可惜电机症状开始出现时 约50-70%的dapmingic神经元已经丢失这对于早期诊断和治疗效果构成巨大挑战药理治疗可以解压电机症状, 但随着疾病进化电机复杂症和严重副作用开始出现在这次审查中,我们探索迄今为止进行的研究,以便用纳米投送系统、替代管理路线和纳米神经学为PD重新使用药整体而言,研究表明这些纳米系统极有可能锁定脑部,改善药效剖面并减少副作用。
The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting considerable advantages, has created challenges for researchers.近几十年来,纳米载体应用中,向皮肤提供药物因其优于口服和侧接管理而引起越来越多的关注。高亮皮肤渗透/ Permeation正面临生物和药物相关 [.]
Der Betrag The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting considerable advantages, has created challenges for researchers.Among the applications of nanocarriers, drug delivery to the skin has attracted increasing attention in recent decades due to its advantages over oral and parenteral administration. Skin penetration/permeation is facing biological and drug related barriers. Different nanocarriers which are used as potential topical formulation were presented. Strength points of nanocarriers were illustrated and each point was correlated to specific nanocarriers(s). Formulation point of view was not ignored and promising constituents were highlighted. Accordingly, this work attempts to discuss the major obstacles surrounding topically applied formulations and different nanocarriers' potential to overcome these barriers to investigate whether their passive penetration through the skin is likely.皮肤解剖视图和遍历路径都简要审查通常认为会影响皮肤渗透的因素从特别穿透式纳米载体的角度进行讨论。纳米载体配方概述,并突出有希望成分帮助调查人员优化纳米载体配方. Der Beitrag Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation erschien zuerst auf Pharma Excipients.
Highlights
Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing.程序启动相继免疫响应是无疤皮肤再生的关键研究中搭建了带级联释放行为的IL-10加载电素纤维电阻纤维释放低浓度 [.]
Der Betrag Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing.程序启动相继免疫响应是无疤皮肤再生的关键研究中搭建了带级联释放行为的IL-10加载电素纤维During the inflammatory phase, the electrospun fiber released a lower concentration of IL-10 within the wound, inhibiting excessive recruitment of inflammatory cells and polarizing macrophages into anti-inflammatory phenotype "M2c" to suppress excessive inflammation response. Macrophages play a crucial regulatory role during sequential skin regeneration process. "Inner-Outer" IL-10-loaded electrospun fiber released the loaded cytokine in cascade. IL-10 of low concentration within the wound inhibited the excessive inflammatory response. Cytokines secreted by "M2c" inhibited the extracellular matrix overproduction. The "Inner-Outer" IL-10-loaded electrospun fiber programmatically activated the sequential immune responses. During the proliferative phase, a higher concentration of IL-10 released by the fiber and the anti-fibrotic cytokines secreted by polarized "M2c" directly acted on dermal fibroblasts to simultaneously inhibit extracellular matrix overdeposition and promote fibroblast migration.iL-Optent/uploads/2021/04/Programblem-imune-actropun-fer-skiner桑托斯 温高曲可编程免疫电阻纤维促进皮肤再生,生物活性素,卷6第10期2021https://doi.org/10.1016/j.bioactmat.2021.02.022. Der Beitrag Programmable immune activating electrospun fibers for skin regeneration erschien zuerst auf Pharma Excipients.
Highlights
See also our video about electrospinning:
Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity.并有可能改善消除细菌和生物膜的工作液相带xixdines/www.pharmaexccepties.com/news/lipsosomes-chitosan-hygel-thexidine/
Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity.s/www.pharmaex接受者.com/chitosan/目标ssssss'blank'rels'noopener'schitosan>/a液相带xixdinemg/mg类嵌入千兆赫。
lockquate>严重抑制亲子研究中生成一氧化二氮并几乎完全减少生物膜编组sedomonas aeruginosa 生物胶片内附入式细菌细胞减少64.2-98.1%Chitosan水合机增强CHX.
见完整研究论文pdf:Der Beitrag Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro erschien zuerst auf Pharma Excipients.
Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience.局部用量表最优处理这种疼痛Poloxamer407热敏聚合物低温液化高温凝胶化
Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience.局部用量表最优处理这种疼痛a hrefss/www.pharmaex接受者.com/product/kolliphor-p407-Micro/研究的目的是评价407gels的凝胶和药送性能,内含diofenac数列配方的凝聚特性从理学上评价skin透析膜、完整的sporcine耳皮和sporcine耳皮肤通过磁带脱包受损评价装有diclofenac的pooxamers药运特性。
a商业凝胶产品和水中diclofenac溶液被用作控制配方Poloxer浓度和凝聚温度逆向变化,并添加高浓度diofenacPoloxenac有效限制二联苯钠渗透有缺陷屏障特性的薄膜,从polexamer407交付二联苯钠与商业凝胶产品检测到的交付没有多大差别24小时交付量没有随着407聚变发生重大变化hrefss//www.pharmaexsubjects.com/produce/kolliphor-p407-micro/'>poroxamer407 可能是对慢性创伤网站管理a hrefsiFiegel J布罗德市P>Der Beltrag
Extracellular vesicles (EVs) include exosomes and microvesicles.细胞在生理和病理条件下释放EVs可与多生物介质隔离,如血浆、唾液和皮肤EVs及其内涵的作用,包括RNA、蛋白质和信号分子,取决于具体的细胞和器官 [.]
Beitrag Extracellular vesicles (EVs) include exosomes and microvesicles.细胞在生理和病理条件下释放EVs可与多生物介质隔离,如血浆、唾液和皮肤。
skin-and-the-Excell-Veclips- in-the-Skin-Ser-Intections-Nanoparts.pdf目标='blank'rel='nobenernoreferr'外细胞织物作用 和它们与Nanop粒子交互世界纳米学和纳米技术杂志2020年;1(1):1006.
DerBeitrag