Gelling行为评价自然口令及其开发前景

Philippe语言 — 周五04+00006:53:00+00

Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources.它们的物理和功能特征可按产品开发应用定制研究的目的是确定从植物源开发凝胶配方并与商业用聚合物Viz比较Carbopol 934、CorbeyMetCellulose、Xanthan、Sodium Alginite.br/ > Methods: Gel配方粘合粘合性并选用其他口香糖并更接近合成对口像 Carbopol 934和Sudium algate自然口香糖提供范围相对较广的特征和生态友好方法,增强配方开发应用性本研究工作理顺天然口香糖在开发药用量表、整形产品和养分配方方面的重要性。

CONCLUSION 用天然口香糖制成的Gels具有可传播性、可破解性和生物敏捷性自然口香糖有良好的凝胶特性,可与常用合成聚合物和半合成聚合物i相仿ecarbol934基础凝胶比例关系基于体外共生测试确定显示一药参数对二药的影响提高集中度时凝胶粘性加增并用同值应力稀释并探索由于粘度提高而高聚性液很难传播,然后低聚减少粘度凝胶,还分析数据,我们可以说粘度与胶的可传播性反比,但直接与表面张力成正比,即ViscosityAL1/E1/SALSS.T瓜尔口香糖被发现具有良好的粘度和可传播性,因此它可作为一种成本效益高、生态友好型替代物,取代carbopol、Xanthan和其他常见凝胶代理物工作证明使用环境友好天然口香糖为潜在凝胶剂用于药用、美容和营养化应用

Key词和素材: 生态友好型代理器、Gelling代理器、Gelproductions、 Muco-adhiGuar Gum, tragacantth和Butrydhyltoxlene,Sodium Alginate,Xanthan,CMC,Carbopol934,MetPeben,Propyl pleben,Proplegeglegle

改善老年病人医学:病人特征与固口服表设计之间的考量改善摇摇经验

Philippe语言 — son,03I202115:30:33+00

Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of drug therapy in primary and secondary care.有明显证据表明,老年病人口中吞吐问题(例如Disphiga)越来越多,特别是考虑到多发性、虚弱和多药化病人时更是如此。Swallowing缺陷对SODF管理有负面影响,导致加入率差和不适当的修改(例如压碎和拆分)。多年来提出了不同的策略,以便通过使用传统管理技术或吞食辅助装置增强SODF吞存经验尽管如此,新配方设计必须通过实施以病人为中心的方法加以考虑,以便有效改善老年病人对SODF的管理与适当的SODF规模缩放并发新片下载全文章:/a/p>或继续阅读斯特盖曼a hrefss/www.mdpi.com/1999-4923/13/131/32目标s药理学2021年、13年、32年/p> 摘自5章:电影编译材料设计增强SODF滚动经验 (以及出版物表7提及的专利见下)

5.1.1Polyvinyl酒精编码日本研究者开发了可膨胀平板涂层,由 >PVA 和carboxyyyl聚合物[161]组成专利应用技术也公之于众[184]另两个专利还分别描述PVA与多环酸/甘油和guar树胶/甘油Cellulose-proproymecellose片甘基coates 编码材料与gelatin[163]和agnate/sepherose其他一些配方描述gellan口香糖使用[172],并描述它与聚乙烯甘醇/高压硫酸钠的进一步组合[173]或plulan/manitol[171]此外,还报告一种配方,内含Aginiate/crice酸钠[186].

5.1.4galatin编码s sqium algate应用为增厚剂,制造涂层材料,在水摄取时积聚并形成凝胶[162]。

5.1.6wax编码 Beeswax和talc反爬行涂层获取优滑属性已在专利中披露[181].

51.7Shellac-basets 组成水溶性shellac 的材料另一种专利描述由shellac/PVP/Hycriprocolose/PEG/sucralos[187]多词性coates 双层多词性涂层材料加之cboxyecellose/PVP建议 [60]并描述丙酸共聚物配方[170].

5.1.9聚乙烯Oxide编码多环乙烷涂层建议作为润滑药用材料涂层可用涂层SODF解析法应用,后加紫外线进程[177].

5.1.10Carrageenan编码胶片改制成易片平滑面的carrageenan和tre由carangeenan/alginate/xanthan口香糖/HPMC/crospovidone组成复杂混合体已被建议为涂层材料,以提高片片吞食能力[180]包括carangeen/agar/gelatin在内的其他组合也报告[183].

a调味涂层解析法,内含通过喷洒或稀释可应用SODF的粘合物和润滑物(如聚沙分解物和多元醇)In addition, a coating gel that was obtained by polymerization and crosslinking of different polysaccharides that contributes to reduced esophageal friction was also suggested [185].

Table 7: Patents addressing new coating materials to enhance swallowability of SODF.

Der Beitrag Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience erschien zuerst auf Pharma Excipients.

喷口递药纳米器使用Ca2+响应去乙基凝胶

汤姆 — 卫星2020年12月26日

The objective of this study is to use a carbohydrate polymer deacetylated gellan gum (DGG) as matrix to design nanocrystals based intranasal in situ gel (IG) for nose-to -brain delivery of drug.HAR-NC模型药用同质喷雾技术编译HAR-NC重新分布于dGG解决方案中并组成ionti晶状HAR在同化和喷雾干燥期间没有变化HAR-NC-IG和0.5%DGG显示精良现场凝聚能力、水保留属性和体外释放行为脑内HAR-NC-IG生物可用性比口口服HAR-NC高25倍,这可归结为HAR-NC和DGG生物沉积属性由鼻液触发的纳米化效果HAR-NC-IG可显著抑制乙酰胆碱酯酶表达方式并增加脑中乙酰胆碱化内容比引用配方内容(p < 0.01)dGG基础纳米晶体凝胶是一个大有前途的载体,可流出易解药,可延长宿期并增加脑中易解药的生物可用性。

/ahrefss/www.sciencedent.com/science/abs/pi/S0378517320311674国际药理学杂志,2020年https://doi.org/10.1016/j.jpharm.20120182.

Der Beitrag

封装类复合物生物可用性

Philippe语言 — Thu,01Octo202005:30:51+00

Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc.这些效果在很大程度上取决于生物机体中的生物可用性生物存取性并因此生物可用性在很大程度上取决于生物体所输入的结构和形式,例如通过复合食物矩阵或净化分离倍数复合体与食物中或消化期间的其他大型分子(蛋白类、脂肪类、饮食纤维类、多功能类)发生交互作用,极大地影响生物接触生物机体,但由于倍数复合体机制复杂,尚未充分检测此区模拟胃消化法是常用体外测试之一,用于评估苯丙化合物生物存取性封装法可积极影响生物可获取性与生物可用性,因为它能确保全版出版物: 塞洛G普兰尼奇MTišma M普契奇科伊奇 Role of the Encapsulation in Bioavailability of Phenolic Compounds. Antioxidants 2020, 9, 923.

Check the encapsulation materials and methods in the following tables as of this publication

Encapsulation of phenolic acids and stilbenes

Core Material	Wall Material	Encapsulation Method
ferulic acid	chitosan-tripolyphosphate pentasodium	ionic gelation
ferulic acid	poly-D,L-lactide-co-glycolide (PLGA)	double emulsion
caffeic acid	poly-D,L-lactide-co-glycolide (PLGA)	emulsion
syringic acid	D-Alpha tocopheryl polyethylene glycol 1000 succinate (TPGS)	thin-film dispersion
trans-resveratrol	zein	electrospraying
trans-resveratrol	poly-D,L-lactide-co-glycolide (PLGA)	precipitation

Encapsulation of flavonoids

Flavonoid Category	Core Material	Wall Material	Encapsulation Method
flavanols	quercetin	chitosan	ionic gelation
flavanols	quercetin	poly(lactic-co-glycolic acid) (PLGA)	emulsion diffusion evaporation
flavanols	quercetin	soluplus micelles	film dispersion
flavanols	quercetin	linseed oil, GMS, P6, Tween 80, 1,1-propylene glycol	high pressure homogenization
flavanols	quercetin	poly-D,L-lactide (PLA)	solvent evaporation
flavanols	quercetin	glycerol monostearate (GMS), medium chaintriglycerides (MCT), soy lecithin	emulsifying and solidifying
flavanols	quercetin	zein, 2-hydroxypropyl-β-cyclodextrin	spray-drying
flavanols	quercetin	casein, 2-hydroxypropyl-β-cyclodextrin	coacervation
flavanols	quercetin	poly(lactic-co-glycolic acid) (PLGA)	solvent displacement
flavanols	quercetin	ethylcellulose	precipitation
flavanols	quercetin	soy lecithin, glyceryl tridecanoate, glyceryl tripalmitate, vitamin E acetate, Kolliphor HS15	phase inversion
flavanols	quercetin	(β-CD)-dodecylcarbonate	freeze-drying
flavanols	kaempferol	chitosan, sodium tripolyphosphate	ionic gelation
flavanols	kaempferol	lecithin–chitosan	electrostatic self-assembly
flavanols	fisetin	DOPC, cholesterol, DODA-PEG2000	liposomes
flavanols	fisetin	PLGA (poly-lactide-co-glycolic acid), HPβCD (hydroxyl propyl beta cyclodextrin)	emulsion, freeze drying
flavones	tangeretin	zein	emulsion
flavones	apigenin	soybean oil, Tween 80	in vitro digestion, in vivo pharmacokinetics
flavones	rutin	chitosan	ionic gelation
flavanones	naringenin	phospholipid, cholesterol, sodium cholate, and isopropyl myristate	liposomes by thin-film dispersion
flavan-3-ols	epigallocatechin gallate (EGCG)	gum arabic, maltodextrin	spray drying
flavan-3-ols	epigallocatechin gallate (EGCG)	chitosan-tripolyphosphate	freeze-drying
flavan-3-ols	catechin hydrate	phosphatidylcholine (PC)	liposomes
flavan-3-ols	catechin hydrate	horse chestnut, water chestnut and lotus stem starch	freeze drying
flavan-3-ols	green tea catechins	soy protein	emulsion
flavan-3-ols	green tea catechins	vitamin C and xylitol, γ-cyclodextrin and hydroxypropylmethyl cellulose phthalate	film-forming
flavan-3-ols	green tea catechins	hydroxypropyl methyl cellulose phthalate	coating
flavan-3-ols	tea catechins	corn oil and polysorbate 80	emulsion
isoflavones	daidzein	phospholipid	film-homogenization
isoflavones	genistein	Soluplus® and Vitamin E d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)	organic solvent evaporation

Encapsulation of anthocyanins

Core Material*	Wall Material	Encapsulation Method
blackberry purees	β-cyclodextrin	molecular inclusion
saffron anthocyanins	β-glucan and β-cyclodextrin	spray drying
Vaccinium ashei extracts	whey protein isolate	spray drying
Bryophyllum pinnatumextract	β-cyclodextrin	emulsion
bran extract	maltodextrin, gum arabic, whey protein isolate	spray drying
bran extract	alginate-whey protein isolate	ionic gelation
sour cherries skins extract	whey proteins isolate	freeze-drying
bilberry extract	whey protein, citrus pectin	emulsification and thermal gelation
anthocyanins standards mixture	cyclodextrins	freeze-drying
anthocyanins standards mixture	chitosan hydrochloride, carboxymethyl chitosan, β-Lactoglobulin	ionic gelation
bilberry extract	pectin amide	extrusion
bilberry extract	pectin amide with an additional shellac coating	emulsification/heat gelation
bilberry extract	whey proteins	spray drying
black carrot extract	polycaprolactone	double emulsion
black carrot extract	cholesterol and non-ionic surfactant (Tween 20)	niosome method
mulberry-extracted anthocyanin	alginate/chitosan	spray drying and external gelation
red pepper waste	whey protein	spray drying and freeze-drying
bilberry extract	whey protein isolate	gelation

* Source of anthocyanins

Keywords: bioaccessibility!模拟胃肠消化目标交付控制释放封装技巧coating materials

Der Beitrag Role of the Encapsulation in Bioavailability of Phenolic Compounds erschien zuerst auf Pharma Excipients.

复元交错牙胶水凝胶作为风波关节炎处理药送系统

Markuskobel — 卫星9月19日2020年6时30分18+00

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint synovial inflammation, as well as cartilage and bone tissue destruction.当前处理RA策略可减少联合炎症,但处理选项仍代表稳定问题,因为它们不足并快速清除因此,数个药服系统(DDS)已经升级解决这一限制问题。可注入gellan口香糖(GG)水凝胶通过物理交叉法减少,并被建议为DDS,但这种交叉联通可产生水凝胶在生理条件中变弱倍感交叉连接度可调整。

在本研究中,tyramine改制gellan口香糖并封装Bemethasone提高用RA治疗病人的特性和安全性物理化学结果显示,有可能用tyramine修改GG,代用率约30%显示高机械强度和抗药性显示受控乙片松释放剖面Ty-GG流化凝胶也显示无细胞毒效,不会对代谢活动及原生细胞扩散产生消极影响此外,主要目标已经实现,因为证明比起单管贝美特松,Ty-GG流水胶效果更有效开发Ty-GG流格代表有希望DDS和可靠替代对RA.slink.spriet.com/article/10/10.s346/020855-9translRes.s.s/doi.org/10.1007s13346-020859

Gellan Gum Thin电影集成化Hycyprayyl-Di-Cyclodexrin

汤姆 — 周五7-20201:30:57+00

Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent.GG-Gly电影被调查为使用fluconazole(生物药理分类系统第一类)作为示范药提供bucal药的潜在系统gly低浓度下药时发生,而gly高浓度下药时则观察到mcoadhisive和机械性能显著退化。

解决所有这些问题的可能方法可能是添加hisypryl-spanids最大高度:无显示器内插字型风格:正常字体重量:正常平凡度量字型尺寸:12px文字缩进:0px文本对齐:左转文本转换式:无字母间距:正常字间间隔:正常溢出- wrap:常态白空格:即时拉普浮点数:无方向:i最大宽度:无0-px0px边界:0px0px边距:0pxposition: relative;" tabindex="0" role="presentation" data-mathml=" $β$ ">β-cyclodextrin (HP- $β "> β$ -CD) to the GG-Gly formulation as a drug-precipitation inhibitor.研究循环extrin加法对GG-Gly电影机械性能、粘合性能、膨胀性能和释放性能使用板型分解器(USP二号)和mlflidic流通装置(MFTD)进行了体外药物释放研究。移动-边界动态模型二推算溶剂有效维度-HP-spanid='mathJax-Eplement-3-Frame'类='MathJax样式='box最大高度:无显示器内插字型风格:正常字体重量:正常平凡度量字型尺寸:12px文字缩进:0px文本对齐:左转文本转换式:无字母间距:正常字间间隔:正常溢出- wrap:常态白空格:即时拉普浮点数:无方向:i最大宽度:无0-px0px边界:0px0px边距:0pxposition: relative;" tabindex="0" role="presentation" data-mathml=" $β$ ">β-CD, fluconazole and complex fluconazole/HP- $β "> β$ -CD in the swelling film.

Experimental results, supported by theoretical modeling, confirmed that gellan gum-low glycerol thin films including HP- $β "> β$ -CD represent a suitable formulation for fluconazole drug delivery.GGG-Gly胶片加载预构复杂密片/HP-spanid最大高度:无显示器内插字型风格:正常字体重量:正常平凡度量字型尺寸:12px文字缩进:0px文本对齐:左转文本转换式:无字母间距:正常字间间隔:正常溢出- wrap:常态白空格:即时拉普浮点数:无方向:i最大宽度:无0-px0px边界:0px0px边距:0pxposition: relative;" tabindex="0" role="presentation" data-mathml=" $β$ ">β-CD.

Download the full article here or read it here

Article Information: Adrover, A.!迪穆齐奥 LTrilli J白兰地CPalicelli P派特拉利托CasadeiM.Agelopyl-e-Cyclodextrin综合处理Gellan Gum Thin电影增强加载效率和 Mucoadhe

电影编译系统切换式提供药

Philippe语言 — 元,2020年8月31日17:25+00

Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression.alginic酸作为平板配方前台使用有限,因为有某些缺陷,如低平板硬度和低压缩性这项工作的目标是提高这些特性,具体化通用于增强表单前接收器功能的化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工工工工工工工工工工工化工工工化工化工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工总体说来,提高甲基化程度产生拉伸强度更高和压缩性更好的片片改代数显示延长分解时间,与引进疏水性后原生alginica最后,用微晶素纤维素和晶素来编译变异变异分解和填充/绑定试剂的功能多功能性测试href="https/www.scient.com/science/pii/S188087171538目标ss'blank'rels'胶片编译凝胶使用量对臂膀、肩膀、大腿内部或腹部生成薄生物沉积薄膜药物溶入胶片编织器中,并嵌入薄膜皮肤中胶片可起外部水库作用或限制向皮肤提供药物从而控制释放药Various gelling agents are listed in the following table (based on "Film forming systems for topical and transdermal drug delivery")

Gelling agent	Properties
Gellan gum	•Anionic polysaccharide •Gel properties depend on the presence of alts •Excellent biocompatibility and degrades into non toxic products
Carbomer (Carbopol®) Grades – ETD 2020, 171, 910, 934, 934P, 940, 1342 NF, 1971P	•Excellent gelling efficiency in low concentrations of 0.25% to 1.5% •pH dependent gelling •Forms clear gel in water
Carboxymethyl cellulose	•Effective in concentrations of 4 to 6%. •Stable between pH 2 and 10 •Incompatible with ethanol
HPMC (E series, F series, K4M, K15M, K100M)	•Effective in concentrations of 2–6% as gelling agent •Produces a smooth, clear spreadable gel
Hydroxy ethyl cellulose	•Effective in concentration of 0.5–1% •Has thickening and stabilizing properties
Poloxamer (polyethylene–polypropylene glycol co-polymer) Grades – 124, 182, 188, 407	•Used in the concentrations of 20–30 % •Thermoreversible gelation-liquid at refrigerated conditions and gel at room temperature
Sepineo P 600 (acrylamide/sodium acryloyldimethyltaurate copolymer)	•Concentration of 0.5–5% used as gelling agent •It has thickening properties in aqueous or organic media over a wide pH range

Film Forming Polymers

Polymers are the foundation of the FFS and a variety of polymers are available for the preparation of these systems.实现所期望的胶片属性,这些聚合物可单独使用或与其他胶片组聚聚合物 ss/sciencedent.com/science/article/pii/S18808617301538#bb0215聚合物在皮肤温度下应形成清晰柔软膜The list of polymers along with their molecular weight and properties are mentioned in this table (based on "Film forming systems for topical and transdermal drug delivery")

Polymer	Properties
Hydroxypropyl Methylcellulose (HPMC) HPMC (E4M, E15, E50M K4M)	• Produce a light, non-greasy uniform film with good texture • Do not interact significantly with other ingredients • Surface active agent, therefore adsorbs water providing easy dispersion, lubricity and comfort feel in occlusive state on application to skin
Ethyl cellulose (EC)	• Nontoxic, nonirritating, nonallergic material • Good film forming properties that form tougher films
Hydroxypropyl cellulose	• Nonionic, pH insensitive polymer • Water soluble
Polyvinyl pyrrolidine (PVP)(PVP K30, PVP VA64	• Solubility in water and other solvents • Adhesive and binding property • Acts as a bioavailability enhancer
Polyvinyl alcohol (PVA)	• Water soluble • Excellent film forming and adhesive properties • Nontoxic and biocompatible
Chitosan	• Excellent film forming ability • Opens the tight junctions of mucosal membrane, thereby enhancing the paracellular permeability and penetration of drug • Controls drug release
Eudragit (polymethacrylates copolymer) Eudragit RS 100, RL 100, NE, RS 30D, S 100	• Transparent, elastic, self-adhesive • Good adhesion to the skin
Silicones Polydimethylsiloxane (PDMS)	• Water vapor permeable film • Adequate substantivity and durable film
Acrylates copolymer Avalure® AC 118, AC 120	• Tough, breathable, abrasion resistant films

Der Beitrag Film forming systems for topical and transdermal drug delivery erschien zuerst auf Pharma Excipients.

设计开发多甲基甲状腺移植gellan口香糖基础pH敏感新药提供系统

Markuskobel — 卫星,2020年5月30日2.3034+00

The objective of the present study was to develop a pH-sensitive drug delivery system by using polymethylmethacrylate-grafted gellan gum (PMMA-g-GG).PMMA-g-GG使用红牛启动机硝酸铵合成自由基聚合响应并编成数组同聚物剖分参数,例如百分比和效率计算,单数和启动者集中效果研究分包产值。

优化用最优响应面法完成批量配接率更高并特征为元素分析(CHN)、FT-IR、DSC、PXRD、sup>1 H-NMR和SEM此外,急性口服毒性研究及组织病理分析显示系合口香糖的非毒性和生物兼容性Mitformin盐粒子使用MMA-GG详细描述并评估生物兼容性和有效性PMMA-g-GG配方M4展示PH敏感度和持续释放12H和发布剖面活性效率研究显示预制配方有很有希望的抗电算潜力PMA-gG-GG配方在不久的将来可归结为辅助抗糖尿病新药提供系统。

s/link.sprianger.com/artems/10/10.s346/020-00777translRes. (2020).https://doi.org/1017s13346-020077

Der Beitrag

易燕口Jelly配方持续发布Gliclazide

Philippe语言 — Mon,5月18日20205:30:08+00

It is a challenge to safely administer sustained release medicines to patients with dysphagia.持续释放片片片不可压碎,多片段粒度大可降低患者可接受性研究的目的是开发即时推送器,为有缺陷的病人持续释放微粒含凝胶物剂的干粉混合体,如悬浮钠和钙离子水分20毫升水分组成10分钟果冻纹理即时Jellies展示出可与商业网际JELLIES相匹配性能,外观性能、风学性能/文体性能和体外吞咽性能人造喉模gliclazide持续释放微粒s持续滑动释放超过15小时,微粒注入jellies显著降低药物释放率新药提供系统为向有缺陷的病人持续放药的长期挑战提供以病人为中心的解决办法,并有可能用于儿科病人下载全出版物:https://www.pharmaexbens.com/wp-content/uploads/2020/05/Easy-to-Swarow-Instant-Formations-slift-Release-Gliclazide-Delivery.pdfMcAuley, Fang Liu
Publication: Journal of Pharmaceutical Sciences
Publisher: Elsevier https://doi.org/10.1016/j.xphs.2020.04.018

Keywords: Dysphagia, Paediatric, Geriatric, Controlled release, Swallowing, Microparticles, Cellets 100, Protanol GP 1740, Kelcogel F, HPMC, Methocel E5, Sentry Polyox WSR N10 LEO NF, Mini-Glatt, fluidized bed

Der Beitrag Easy to Swallow "Instant" Jelly Formulations for Sustained Release Gliclazide Delivery erschien zuerst auf Pharma Excipients.

gellan口香糖衍生物即时凝胶聚合物

Philippe语言 — Thu, 2020年5月14日05:45:26+00

The aim of the present study was the development of a novel gellan gum derivative exhibiting mucoadhesive properties for nasal application.

Accomplishing this, amino groups have been introduced to the polymeric backbone.所生成合成产品特征化为附氨基组数,水分化、Zeta潜力和凝胶特征以旋转圆柱和抗拉研究对 Mucoadhisive研究协同性进行评估紧接红细胞/细胞毒性评价,调查对鼻膜上下角细胞周期的影响。

Results显示联通率达1259.50+75.98mol/g聚合物并加速水化衍生物聚合物/粘合物粘合度增加32倍和14倍扩展粘合时间验证了未变凝胶增强粘合度耐用性研究显示共加工作9倍和3.75倍最大分遣队细胞膜没有严重缺陷CBF研究证明应用新衍生物可逆抑制性。

aahrefs/www.scient.com/science/abs/bs/s014113020299gems='blank'rels

Gellan口香糖及其解码衍生物即现场凝胶粘合配方

Philippe语言 — Frii,2020年2月21日10:52:00+00

Gellan gum was chemically modified by the reaction with methacrylic anhydride to produce derivatives with 6, 14 and 49% methacrylation.iNMR和FTIR分光镜确认这些衍生物的结构和替代度与原状凝胶相比,这些衍生物多防水并形成水中的扰动解析法体外研究配方含凝胶素及其甲状腺衍生物显示,甲状腺变异会增加保留物上。

/p>ivore实验含凝胶和甲状腺变衍生物pilcarpine盐化物配方证明所有聚合物都显著增强药效,但观察聚氨酸酯优性能为6%Download the full publication here

This video abstract describes our paper "Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: in vitro and in vivo studies" published in International Journal of Pharmaceutics https://authors.elsevier.com/a/1aW0-1…

Der Beitrag Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: In vitro and in vivo studies erschien zuerst auf Pharma Excipients.

Gellan Gum-Pharma前接收器