Particle engineering via spray drying was used to develop a dry powder presentation of an adjuvanted tuberculosis vaccine candidate.使用三叉素前接收系统设计出既可热性又适合呼吸传递的演示喷雾驱动疫苗粉的稳定性在一年多多以来各种存储温度评估(20,5, ts/p>doreBeitrag Particle engineering via spray drying was used to develop a dry powder presentation of an adjuvanted tuberculosis vaccine candidate.使用三叉素前接收系统设计出既可热性又适合呼吸传递的演示The stability of the spray-dried vaccine powder was assessed over one year at various storage temperatures (-20, 5, 25, 40, 50 °C) in terms of powder stability, adjuvant stability, and antigen stability. Liquid vaccines can be spray-dried into a dry powder to enhance thermostability. These dry vaccine powders can be inhaled directly into the lungs. The addition of trileucine greatly improves the vaccine powder lung dose. Lung dose was maintained even after 1 year of storage at 40 °C. A formulation without trileucine was included as a control.结果表明内粒子结构与外粒子形态保持一年为40摄氏度,而控制案例显示微粒在相同存储条件下有小阻燃运动内容得到维护,粉状固态在所有存储温度方面都保持无变喷雾性能评估与商业干粉吸入器并用人口交模型一年后温度可达40摄氏度时,所有样本均保持释放剂量和肺剂量抗生素在控制配方中完全退化为40摄氏7个月存储对比之下,45%的抗原在50摄氏度存储一年后仍存在于trehalose-trilecine配方比较而言,在37摄氏度存储一个月后,抗原完全退化喷雾驱动trehalose-trilecine疫苗粉经高温存储一年后明显保持可吸入性能并改进疫苗的全面可渗透性。 Der Betrag
Highlights
Views,2021年https://doi.org/10.1016/j.vaccine2021.07.002.
Localized delivery of drugs or nanoparticles for oral cancer is always preferred.添加式制造驱动三维打印小片交付纳米粒子为前沿交付透视提供了新维度纳米结构式脂载体装入三维瓦斐斯内,用聚性(乙烯醇)印制聚合物Wafers显示加载容量50+2.5 mg并附理想表面 [.]
Der Betrag Localized delivery of drugs or nanoparticles for oral cancer is always preferred.adtive制造 Der Beitrag Fused deposition modeling (FDM)-mediated 3D-printed mouth-dissolving wafers loaded with nanostructured lipid carriers (NLCs) for in vitro release erschien zuerst auf Pharma Excipients.
Find out more about 3D Printing here
One of the most realistic approaches that could deliver actives (pharmaceuticals/cosmetics) deep into skin layer is encapsulation into nanoparticles (NP).分子层次理解从NP向皮肤主动交付机制,与其合成和特征描述相比,很少得到研究。主动移植和渗透机制
Der Betrag
One of the most realistic approaches that could deliver actives (pharmaceuticals/cosmetics) deep into skin layer is encapsulation into nanoparticles (NP).分子层次理解从NP向皮肤主动交付机制,与其合成和特征描述相比,很少得到研究。主动移位渗透最外层皮肤、直角膜、分子动态模拟并附实验结果的底层机制报告。
a单片分子模型使用当前最先进方法构建,整合三种最丰富的皮肤脂:ceramide、免费脂肪酸和chosterolfruliceare使用模型主动性并加载https///www.pharmaexbenses.com/product/gelcire-50-13/MD模拟说明优先FA负载NP快速接近皮肤表面FA从NP表面移到皮肤表面,因为NP皮肤交互比FANP强FA向皮肤表面释放后,会缓慢渗透深入皮肤双层自由能量和阻抗渗透不仅表示FA自发从散装转向皮肤表面,还显示渗透主屏障存在于脂肪疏水尾巴中间主屏障区比大容量大得多地获取FA扩散量。估计渗透系数(logP)发现比实验高渗透过程由MD模拟完全匹配实验实验建议分子模拟平台帮助从加载NP向皮肤主动交付各种关键洞察力,并便利设计开发基于NP的新配方用于跨模送药/Cosmetics.sc.org/en/content/artlelanding2021/nr/d1r0265f#.divAbstragupta, ssurjitdasspan_sergtarefss/simation-lipid-nanoparticle-skin/mellex模拟Lipsate从LipsidNanop粒子移位并渗透皮肤:补充实验
Recently, bioinspired cell-derived nanovesicles (CDNs) have gained much interest in the field of nanomedicine due to the preservation of biomolecular structure characteristics derived from their parent cells, which impart CDNs with unique properties in terms of binding and uptake by target cells and intrinsic biological activities.s/www.pharmaexcceptips.com/news/lyophilization-cardio保护活动/
Recently, bioinspired cell-derived nanovesicles (CDNs) have gained much interest in the field of nanomedicine due to the preservation of biomolecular structure characteristics derived from their parent cells, which impart CDNs with unique properties in terms of binding and uptake by target cells and intrinsic biological activities.单片机可轻而易举地生成单片机件,但用于治疗目的的单片机件在水分长期存储期间因物理和化学不稳定而受到极大阻扰。
在本研究中,我们构思了液化方法,维护单片机机件稳定性(卷积大小和蛋白含量)、结构完整性和生物活动等关键特征,以便能以冷冻式长期存储与lyoprotect sucrose相比,treshose受保护CDN显示高得多玻璃转换温度和低残留水分ATR-FTIR和远UV循环二变形评估显示,lyo保护者有效维护细胞蛋白二级结构。
重构后,lyo保护CDN高效关联HeLa细胞、CT26细胞和骨源宏与新编制CDN相仿yo保护新编CDNs首次报告目标受创心脏并24H内自生保护效果,可归结为心肌缺损/复发动物模型内CDNs抗氧化能力divity-produce-Cell-Derive-Nanovescles.pdf目标='blank'rel=nopener'黄市王XChng W.H.Venkatesan G.扎科娃O华克MG沙皇,B暴风 G王JWPastrin GLyocrication保留生物启发细胞-DerivedNanovesics Intripse保护活动。 药理 2021 , 13 ,1052https://doi.org/10.3390/pharmaceutics13071052Der Beitrag Lyophilization Preserves the Intrinsic Cardioprotective Activity of Bioinspired Cell-Derived Nanovesicles erschien zuerst auf Pharma Excipients.
Nanotechnology provides the means to design and fabricate delivery vehicles capable of overcoming physiologically imposed obstacles and undesirable side effects of systemic drug delivery.协议允许最大目标选择效果并因此提高治疗效率近些年来,多疑硅纳米粒子激发对纳米医学研究圈的兴趣,特别是有希望应用 [.]
此外,还讨论MSNP注入或口服管理吸收、传播和分解过程,因为它们是MSNP潜在使用的关键方向影响MSNP体积归宿的因素也将突出显示,主要焦点为粒子大小、形态学、孔隙性、表面功能和氧化并发可提高生物兼容性、监控放药或提高肿瘤细胞覆盖MSNP上下文还覆盖并讨论这些方面.
/ncbi.nlm.nih.gov/342385/"目标='blank're光谱Silica南虫应用最新进展库尔药德利夫2021Jul 8doi: 10.2174/1567201818666210708123007.Epub前打印PMID:3423885.
DerBeitrag
We aimed to examine the impact of milling of extrudates prepared via nanoextrusion and the resulting matrix surface area of the particles on griseofulvin (GF, a model poorly soluble drug) release during in vitro dissolution.微软GF纳米悬浮器聚合物(Sol:Solplopol-P407或HPC:Hysypraysolute)和decylsufte
We aimed to examine the impact of milling of extrudates prepared via nanoextrusion and the resulting matrix surface area of the particles on griseofulvin (GF, a model poorly soluble drug) release during in vitro dissolution.微软GF纳米拷贝ss/www.pharmaexsubjects.com/productions/soluplos/XRPD-SEM结果显示,纳米扩展生成GF纳米合成件与Kol/HPC并发Sol8.9 mgGF剂量(非超饱和条件)反射率参数较高sup3 msup2 /cmsup3>/sup3>ASD超饱和度优于纳米合成值,GFACD只有10%,190x10sup+3 msup2 2sup>2/sup>/cmsup>3 /sup2 /sup3>/sup3 弗瑞CSkros J徐O拉赫曼M阿扎德M戴夫R比尔吉里市矩阵表面积对通过纳米扩展编译的Excruits释放Griseofulvin。 药理 2021 , 13 ,1036https://doi.org/10.3390/pharmatutics1307136
Nanosized particles have appealing attributes, which have gotten impressive consideration in the last few decades.聚合纳米粒子(PNP)为粒子或粒子材料,其尺寸在一维中至少介于10-100纳米范围体积极小、体积高区比、金枪鱼孔粒子、聚合纳米粒子应用到各种 [...]
Der BeitragNanosized particles have appealing attributes, which have gotten impressive consideration in the last few decades.聚合纳米粒子(PNP)为粒子或粒子材料,其尺寸在一维中至少介于10-100纳米范围体积极小、体积高面积比高、金枪鱼孔粒子、聚合纳米粒子被用于不同领域的各种应用,例如药物提供、生物传感器、刺激性货运交付、纳米合成物、农业和环境应用最新开发无机纳米粒子聚合网络允许改变聚合物物理和化学特性,正如聚合物网络新亮点执行一样。
Congated聚合纳米粒子是深入灵活的纳米组织材料,可想象地发现不同科学和工程分支的应用,例如光电学、光学学、生物成像学、生物检测学和纳米医学期望大小和独特性、生物相容性和低毒性使这些材料对前文提到的应用产生深刻的吸引力聚合纳米粒子(NPs)是纳米医学应用最常用纳米材料之一极端兴趣在于聚合NP改变当前药方的能力聚合NP用法包含提供药品,例如药方相交并联结、辅助药法、刺激响应系统、成像模式和定序学可生物降解聚合纳米结构表示各种修复应用中超常保证,例如分析、成像、静默投送、美化代理物、器官嵌入和组织设计。bp除此以外,最近多聚合物领域研究开发可增强聚合纳米结构清晰功能以平衡金枪鱼应用简洁审查强调过去几十年开发的聚合纳米粒子各种预想方法及其在不同科学分支中的使用,如治疗学、光电学、催化学和磁应用等,同时强调新产生聚合粒子理疗法商业化的若干挑战性问题并评论聚合纳米粒子未来未来数十年在不同科学领域应用Continue on polymer nanoparticles-preparations
Article information: (2021) Polymer nanoparticles-preparations, applications and future insights: a concise review, Polymer-Plastics Technology and Materials, DOI: 10.1080/25740881.2021.1939715
Der Beitrag Polymer nanoparticles-preparations, applications and future insights: a concise review erschien zuerst auf Pharma Excipients.
Background and purpose: Omeprazole (OMP) is broadly used for the treatment of gastroesophageal reflux and other acid-related diseases.当前研究旨在准备内嵌内含OMP的纳米粒子,实现稳定火药配方并易向儿童配方实验方法:纳米粒子由复杂叠加法组成,使用千山和欧卓L100/55(EU)和[.]
Beitrag Background and purpose: Omeprazole (OMP) is broadly used for the treatment of gastroesophageal reflux and other acid-related diseases.当前研究旨在编译嵌入式纳米粒子OMP实现稳定火药配方方便儿童使用。
Conclusion and implication: Our results indicated that the enteric EU/CTS nanoparticles were successfully prepared via a complex coacervation method and their efficacy could be comparable with commercial OMP pellets.
Download the full article as a PDF here or read it here
Materials: EL-100-55 (EU) was obtained from Rohm Pharma GMBH (Weiterstadt, Germany).OMP,CTS(概念度:85%,粘度:20cps(5g/L))和
Beitrag
Laser radiation has been shown to be a promising approach for in situ amorphization, i.e., drug amorphization inside the final dosage form.接触激光辐射后获取高温温度高于玻璃转换温度聚合物时,药分解成移动聚合物s/www.pharmaexsubjects.com/news/m分子量-pvp/
Laser radiation has been shown to be a promising approach for in situ amorphization, i.e., drug amorphization inside the final dosage form.接触激光辐射后获取高温温度高于聚合物的玻璃转换温度(span类='html-itic'>T g )时,药会分解成移动聚合物聚合物的溶性、药粒大小和药分子大小都取决于聚合物的粘合性。
Download the full article as a PDF here or read it here
Materials: Celecoxib (CCX, Mw = 381.4 g/mol), indomethacin (IND, Mw = 357.8 g/mol), naproxen (NAP, Mw = 230.3 g/mol) and magnesium stearate (Mw = 591.3 g/mol) were purchased from Fagron Nordic A/S (Copenhagen, Denmark).Kollidon® 12 PF (polyvinylpyrrolidone (PVP), PVP12, Mw ~2500 g/mol), Kollidon® 17 PF (PVP17, Mw ~9000 g/mol) and Kollidon® 25 (PVP25, Mw ~24,000 g/mol) were a kind gift from BASF (Ludwigshafen, Germany).
Silver acetate (99.8% anhydrous) was purchased from Alfa Aesar (Kandel, Germany).六甲基二异丙烷(zü98%)、乙联苯(99.8%反水)和2-乙乙酸(99%)从Sigma-Aldrich购买(瑞典Stockholm)。氧气流量:5.0L/min来自Strandmøllen(瑞典Ljungby)。
div类='html-p'>Ethanol(>99.7%,HPLC级)从VWR国际公司(比利时Leuven)购买向Sigma-Aldrich(Søborg,丹麦)购买了乙联乙酸和三联乙酸HPLC实验移动级净水使用LabWade系统MilliQ水系统编译所有化学物均按实收方式使用. Molecules 2021 , 26 ,4035https://doi.org/10.3390/molecules26134035>Der Beitrag The high-throughput drying and encapsulation technique called electrospraying assisted by pressurized gas (EAPG) was used for the first time to produce nanostructured valsartan within microparticles of excipients.Valsartan不易吸附和脂质溶解药获选,因为它被认为是BCS二级药的好模式hrefs/s/www.pharmaexccidents.com/organic-stemcs/hpc-hyproprophecellulose/球形微粒 ca 4微米获取后,Varstar纳米粒子显示介于150至650纳米之间广角X射线散射和差分扫描卡路里确认valstar比商业源低和/或定义更多,光子相关光谱传输电子显微镜证明它以受控尺寸纳米粒子形式分布和分布。 https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.1c00098 Der Beitrag Nanostructured Valsartan Microparticles with Enhanced Bioavailability Produced by High-Throughput Electrohydrodynamic Room-Temperature Atomization erschien zuerst auf Pharma Excipients.
Publication Date:June 28, 2021
Nowadays, there has been an increased demand of nanoparticulate-based drug delivery as nanoparticles (NPs) generally give more advantages over the conventional drug carriers for targeting in various parameters like more drug encapsulation, more stability and site specificity, sustained release profile and the ability to deliver both lyophilic and lyophobic types of drug particles using different […]
Der Beitrag Solvent Emulsification Evaporation and Solvent Emulsification Diffusion Techniques for Nanoparticles erschien zuerst auf Pharma Excipients.
Nowadays, there has been an increased demand of nanoparticulate-based drug delivery as nanoparticles (NPs) generally give more advantages over the conventional drug carriers for targeting in various parameters like more drug encapsulation, more stability and site specificity, sustained release profile and the ability to deliver both lyophilic and lyophobic types of drug particles using different modes of administration.
Nanocarriers have been expansively studied as particulate drug delivery in the field of pharmaceuticals, due to their controlled and sustained release properties, small size and biocompatibility with body tissues.制造技术制作纳米粒子在实现其特定应用期望属性方面发挥着关键作用。数种方法编译纳米粒子在过去几十年中开发,这些方法分类基础是粒子编组直接发生聚合反射或纳米粒子表单从预制聚合物或离子凝胶法中直接产生。
Nap粒子编译方法选择高度依赖聚合物和药复合物的物理化学特性聚合纳米粒子通常是单片聚合使用阴性聚合物或编译溶性聚合物同质分布法制造的,该聚合物使用各种方法提供纳米粒子,如/sprinanger.com/capter/10.10107/978-3030-50703-912溶性反射和溶性反射技术插文:PatelJ.K.PathakY.V纳米粒子制造新技术Springer Chamhttps://doi.org/10.1007/978-3-030-50703-9_12
Der Beitrag Solvent Emulsification Evaporation and Solvent Emulsification Diffusion Techniques for Nanoparticles erschien zuerst auf Pharma Excipients.
The emergence of multidrug resistance (MDR) in malignant tumors is the primary reason for invalid chemotherapy.抗菌素药常受肿瘤细胞MDR的不利影响使用传统药的处理有特定药目标,几乎无法规范MDR细胞复杂信号路径,因为MDR复杂编组机制s/www.pharmaexsubjects.com/niooplatform-自然产品/
The emergence of multidrug resistance (MDR) in malignant tumors is the primary reason for invalid chemotherapy.抗菌素药常受肿瘤细胞MDR的不利影响使用传统药的处理有特定药目标,很难规范多元元数据交换机复杂信号路径,因为多元数据交换机复杂编组机制:
,自然产品有正面优势,如高效率、低毒性和锁定多机制路径的能力与多元数据交换机相关自然产品像MDR逆向代理物那样与chemistics协同并增强肿瘤细胞对chemistics的敏感度,用纳米载体联运自然产品和抗声波药使肿瘤细胞对MDR产生最大协同效果本审查归纳出MDR分子机制、自然产品与chemetrotics消解复杂MDR机制的优势和自然产品类型机制。
Meanhy未来前景分析预期会大大改善自然产品和chemiste系统在癌症中逆向传输量。Der Beitrag Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant erschien zuerst auf Pharma Excipients.
Phenytoin is a low aqueous solubility antiepileptic drug, but its phosphate ester prodrug fosphenytoin is soluble, although less permeable.上项研究中,水基fostentoin内部管理导致苯丁生物利用率高于静脉注射线,但延迟使用工程中,我们假设编译推理词关联 [.]
Der Betrag Phenytoin is a low aqueous solubility antiepileptic drug, but its phosphate ester prodrug fosphenytoin is soluble, although less permeable.上项研究中,水基fostentoin内部管理导致苯丁生物利用率高于静脉注射线,但延迟使用这项工作中,我们假设编译prodrugfephenytoin和drugephentoin关联化(主动和易变形式)可能导致更快和/或更有效的脑定位。 后经内管后小鼠对含有fophytoin和phytoin的选定微模进行药理学评价,并比较仅含fophytoin的类似微模这两种微模短短时间点导致脑药含量高于以前开发的较简单水基fopenytoin配方,这很可能归因于微模增强渗透效果。 science/abs/pii/S09280982190目标ss/blankserPires,AnaCFazendeiro,Márcio Rodrigues,Gilberto Alves,Adriana O桑托斯针头对脑投送并结合微模-配方开发与药效学。 2021年欧洲药理学杂志https://doi.org/10.1016/j.ejps.2021109.
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated.药聚合物综合作用研究 (i) 聚合物物理化学特性,例如玻璃转换温度和聚合物溶解性 [.]
>Beitrag In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated.药-聚合物组合研究对以下因素的影响:(一)聚合物物理化学特性,例如玻璃转换温度(span类='html-itic'>T/spansub>g/sub>和(二)药-聚合物溶解率和原位药变换度。 协议编译包含30 wx,69.25wt%聚合物,0.5wt%润滑剂和0.25wt%mic纳米粒子并暴露于近红外激光辐射接触激光辐射后,SPs生成热量,允许药分解聚合物温度高于span类='html-itic'>T g TDStart. The findings of this study showed that the concept of laser-induced in situ drug amorphization is applicable to a range of polymers if the drug is soluble in the polymer and temperatures during the process are above TDStart. Download the full article as a PDF here or read it here Materials: Celecoxib (CCX, Mw = 381.4 g/mol) and magnesium stearate (MgSt, Mw = 591.3 g/mol) were purchased from Fagron Nordic A/S (Copenhagen, Denmark).Kollidon® VA64 (VA64, polyvinylpyrrolidone-vinyl acetate copolymer, Mw = 38,200 g/mol) and Soluplus® (Soluplus, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, Mw = 118,000 g/mol) were kindly supplied by BASF (Ludwigshafen, Germany).Shin-EQOAT /sup>京京市Eudragit® EPO (EPO, Amino methacrylate copolymer, Mw = 47,000 g/mol) and Eudragit® EL 100 (EL100, anionic methacrylic acid methyl methacrylate copolymer, Mw = 125,000 g/mol) were supplied as a gift from Evonik Nutrition & Care GmbH (Darmstadt, Germany).Parteck® MXP Polyvinyl alcohol (PVA, Mw = 26,300 g/mol) was a gift from Merck KGaA (Darmstadt, Germany). Silver acetate (99.8% anhydrous) was purchased from Alfa Aesar (Kandel, Germany).六甲基二异丙烷(zü98%)、乙联苯(99.8%反水)和2-乙乙酸(99%)从Sigma-Aldrich购买(瑞典Stockholm)。喷雾高温合成氧气来自Strandmøllen(Ljungby,瑞典)。 form信息:HempelN.J默克尔P诺普MM贝尔特森RTeleki ASotiriouG.ALöbmannK.药-软溶性对Situ药使用光热高压南粒子变形的影响。 药理 2021 , 13 917https://doi.org/10.3390/pharmaceutics13060917 Der Beitrag The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles erschien zuerst auf Pharma Excipients.
Ethanol(>99.7%,HPLC级)从VWR国际公司购买(Leuven,比利时)。HPLC实验移动级净水使用LabWade系统MilliQ水系统编译silicagel带指示器gel所有化学品均按实收方式使用 。
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The continuous production of drug delivery systems assisted by microfluidics has drawn a growing interest because of the high reproducibility, low batch-to-batch variations, narrow and controlled particle size distributions and scale-up ease induced by this kind of processes.微流dics为高通量筛选过程参数并实现过程特征提供契机 [.]
Der Beitrag The continuous production of drug delivery systems assisted by microfluidics has drawn a growing interest because of the high reproducibility, low batch-to-batch variations, narrow and controlled particle size distributions and scale-up ease induced by this kind of processes.微流化技术为高吞筛选过程参数和尽可能近产品实施过程定性技术提供了机会。 本文建议最优合理开发芯片成本和设计第一,使用两种常见添加制造技术,即装配沉积建模和多喷气建模以原型定制3D微流化设备(芯片和连接器)。第二,通过制造透明硅/玻璃芯片并配有相似通道几何,但新方法获取的深反应离子嵌入技术适合本地小角X射线分布特征描述。 LNCs成功由相位反射构件进程生成,高单片尺寸从25nm至100m不等,并使用3D打印和DRIE技术制造芯片配制透明Si/Glass芯片还用于小角X射线散射分析LNC配方与PIC进程3D打印和DRIE技术及其各自的长处都从成本、易部署和处理GALECHT点上讨论.
Der Beitrag Galenic Lab-on-a-Chip concept for lipid nanocapsules production erschien zuerst auf Pharma Excipients.