Thesis findings 1.Actylsaliclice首次合成流式反应器设计实验研究以优化两个合成步骤:乙基酸消除杂质应用分配最优条件高产纯度实现

Thesis findings

1.Actylsaliclice首次合成流式反应器设计实验研究以优化两个合成步骤:乙基酸消除杂质通过应用分配最优条件高产量和纯度实现(>95%ASA和<3%SA)。二级裁剪步骤均优化使用和不使用溶解聚合前处理器,因此最后反应混合器准备直接再处理电脉冲或连续结晶[一、十四、十六、十七、十九]

2s/www.pharmaex接收者.com/tag/electrospinning/高电压连接流化学微反应器,挥发性构件蒸发,API嵌入无变纳米纤维以这种方式直接整理反应混合,在编译前不需要固液分离适当通风后剩余溶剂量可降低到监管限值以下[一、十四、十六、十七、十九]

3开发并应用机器控制电阻产品并连续端对端生产口解网配方乙酰加硫纤维-直接由流响应混合制成-收集到水溶载膜表面成型双层条接通割机机制并切入小剂量单元备供病人管理良好的内容一致性和低残留水分性在系统长8小时操作期间得到确认[一、十四、十六、十七、十九]

4开发连续系统应用范围扩大到生产ODW配方,配方含水溶性不良复合物CARCAR加载纳米机ES优化以获取稳定过程纤维收集到变换拉布兰载波面上:柠檬酸嵌入膜中,以在分解测试中起pH修饰作用生成ODW配方立即解析确认条件模拟口腔4小时连续生产CAR加载ODW显示适当的内容一致性和纤维残留溶剂内容符合规范要求,二次干燥时对室温应用

5混合混合产品清除连续结晶设备首次直接连接到连续过滤 CarUSel设备综合系统实现稳定连续操作后,两个合并步骤相优化,流程尾端获取流水晶素极品[三、四、十五]

6.关键晶化过程参数对滤出产品质量的影响首次在一个综合连续过滤系统内确定。我们发现只有温度会影响滤波产粒度,而停留时间和温度都会影响水分含量actylsaliclic晶体不影响用连续过滤旋转机装置过滤过程晶体可适当干燥以获取水晶粉流性良好,并适用于下游连续流程[三、四、十五]

7连续过滤药材进一步处理成连续混合微晶素纤维素并首次生产传统压缩片片混合效率由内联NIR检测制片板显示基于联机NIR和离线HPLC测量物内容一致性差极小端对端生成最广压缩片片片度表[IV, XV]

Download the thesis here: Development of integrated continuous pharmaceutical technologies

or continue reading here: Development of integrated continuous pharmaceutical technologies – Ph.D.Andrásdos-spanspan样式=text变换原创OLAH DOCTORAL SCHOOL

Excipients used in the experimental part of the thesis: Polyvinylpyrrolidone K30 (Kollidon® 30), Polyoxyethylen sorbitan mono-oleat (Tween® 80),α-1,4-!α-1,6-glucan (Pullulan®), (2-Hydroxypropyl)-β- cyclodextrin (HPβCD), Citric acid, Microcrystalline cellulose (Vivapur® 200)

Der Beitrag Development of integrated continuous pharmaceutical technologies erschien zuerst auf Pharma Excipients.

The aim of this study was to prepare pullulan-based orally disintegrating films (ODFs) containing amlodipine besylate, an anti-hypertensive drug, by the solvent casting method.九种不同的ODF配方(F1-F9)使用不同的增塑剂(glycerol、srabol、pryleglycol)和不同的超级分解器(croscarlose钠、starkglycolate、crospovidone)制作高亮超强度为 [.]

DerBeitrag

The aim of this study was to prepare pullulan-based orally disintegrating films (ODFs) containing amlodipine besylate, an anti-hypertensive drug, by the solvent casting method.For this purpose, nine different ODF formulations (F1-F9) were prepared by using different plasticizers (glycerol, sorbitol, propylene glycol) and different superdisintegrants (croscarmellose sodium, sodium starch glycolate, crospovidone).

Highlights

Hypertension is a common public health problem in all countries of the world.

Oral administration is the most preferred route of administration.

The disintegration time of pullulan-based amlodipine besylate ODF was determined as 28.8 s according to the drop method and 51.3 s according to the petri dish method.

Pullulan is a polymer as a film-forming agent in orally disintegrating films.

Amlodipine besylate orally disintegrating films are not commercially available yet.

FD&C Green and aspartame were used as coloring agent and sweetener, respectively.预编解析结果显示,确定最佳ODF(F9)并进行各种定性研究,如质量一致性、胶片厚度、电影表面pH值和机械性能(如断线延长、拉伸强度、青年模值和折叠耐用性)、水分内容、分解时间、内容一致性和分解测试、X光、DSC、SEM和短期稳定性分析F9配方的循环毒性和渗透性研究是在人表层剖面性肾上腺素(Caco-2)细胞线上进行的。F9配方有适当的形态学和机械性能并分解到51.3s解析研究显示78.1%的安眠药Besylate从F9配方20分钟解析细胞培养研究表明配方对Caco2细胞没有剧毒效果Caco2倍增火药和amlodipineylateODFs通过所有这些研究,我们建议使用拉木兰基础amlodipinesylateODFs提高管理和病人顺从性Continue on Development and Characterization of Pullulan-based Orally Disintegrating Films Containing Amlodipine Besylate

Keywords Amlodipine besylate, In vitro dissolution, Oral disintegrating films, Permeability, Pullulan, Glycerol, sorbitol, Propylene glycol, crospovidone, croscarmellose sodium, sodium starch glycolate, Aspartame.

Der Beitrag Development and Characterization of Pullulan-based Orally Disintegrating Films Containing Amlodipine Besylate erschien zuerst auf Pharma Excipients.

Active packaging incorporating antioxidants and antimicrobials is creating a niche in the market and becoming increasingly important.这项工作的主要目标是设计生物活性双层薄膜(sein/pululan),并配含甘油基本油双层胶片完全特征化 物理屏障 抗氧化剂 抗菌素s/www.pharmaexsubjects.com/antioxidant/Bioactive-Bilayer-films/

Active packaging incorporating antioxidants and antimicrobials is creating a niche in the market and becoming increasingly important.这项工作的主要目标是设计生物活性双层薄膜(sein/pululan),并配含甘油基本油双层胶片完全特征化 物理屏障 抗氧化剂 抗菌素高性能液相色谱加二极数组检测器HPLC-DAD评价了异丙基棕榈油主要复合物释放运动扫描电子显微镜剖面图双层片清晰显示两层电影开发双层薄膜除显示阻抗自由基体和抑制脂过敏能力外,还能够抑制已知食物寄生病原体(Ecrococcus fiecalis和Listeria单细胞原体)生长含液态基本油的双层薄膜释放电动剖面图显示,室温50%乙醇释放效果更高,表示二层薄膜应用半脂肪食品会更有效。

DerBeitrag .com/antioxidant/Bioactive-Bilayer-films/ //www.novoestroim.com/pullulan/edible-polymers-an-insight-into-its-application-in-food-biomedicine-and-cosmetics/ Philippe语言 Thu, 16Jul 20205:30:51+00 嘴唇 新闻发布 蛋白质 普鲁兰 配方 //www.novoestroim.com/?p=155578

Edible polymers refer to the polymeric materials which can be consumed by human beings, animals or microorganisms without any noxious effects towards health.生物类集、蛋白质和脂质类集,主要在功能食品产业(食品打包和养分保护)和生物医学领域增加应用可食聚合物可消化 [.]

>Der Beitrag s/ss/www.pharmaexsubjects.com/pululan/edible-聚合物-an-inight-intoits-application-in-food-bioCeph-and-cometics/''Edible聚合物:深入了解其在食品、生物医学和化妆品中的应用 erschiertzuft

Edible polymers refer to the polymeric materials which can be consumed by human beings, animals or microorganisms without any noxious effects towards health.They are categorized into polysaccharides, proteins and lipids, and have gained increasing application mainly in functional food industries (food packaging and nutrients protection) and biomedical fields.

Highlights
• Edible polymers can be consumed by living being without any noxious health effect.

• Polysaccharides, lipids and proteins are three main sources of edible polymers(EP).

• Food, biomedicine and cosmetics are main applications of EP based products.

• EP can reduce contamination and produce eco-friendly/recyclable materials.

• Nanotechnology and functional additives are used in smart/active EP based products.

Background
With an ever increasing demand for green materials to produce new, environmentally safe and high-quality products, edible polymers from natural polymeric materials have been attracting considerable attention in recent years.食用聚合物主要由多岩层、蛋白质和脂质组成,这些自然素材很容易被动物和人类消化而不会对健康产生有害影响。With the attractive features of the edible polymers such as biodegradability and bio/environmental compatibility over non-biodegradable synthetic polymers, these polymers have found wide-spread applications in food, agricultural industries, and biomedical fields.

Scope and approach
The current review mainly focus on the diversification of different sources of raw and edible polymeric materials, various forms or shapes (such as particles and films applied in green and smart textiles) along with the methods of fabrication, and applications as biofilms/coating technologies (for foods preservation), active/smart food packaging, functional food coating, smart drug delivery, wound dressing, tissue engineering, medical devices, personal care products, water/wastewater treatment and energies.提高机械性能、渗透性能和功能性是开发多机类复合物、蛋白质和脂质的主要动机,在新食用复合物多样性应用剖面下讨论这些特征。安全和商业方面可食用产品在本审查中也讨论。

Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings.本研究旨在为接触结核病的儿童开发异语管片ODF使用电脉冲生成自然聚合物和半合成聚合物混合水解法[…]

Der Beitrag Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment erschien zuerst auf Pharma Excipients.