This paper deals with uniformly surface modification of mesoporous silica nanoparticles by applying dielectric barrier discharge (DBD) plasma as an energy-efficient and green approach.silica纳米粒子从稻壳合成成经济生物兼容自然源高亮光谱硅粒子从稻壳成功合成为农业废品[.]
Der Beitrag
This paper deals with uniformly surface modification of mesoporous silica nanoparticles by applying dielectric barrier discharge (DBD) plasma as an energy-efficient and green approach.First, the mesoporous silica nanoparticles were synthesized from rice husk (RMSN-D) as an economic and biocompatible natural source.
Highlights
Mesoporous silica nanoparticle was successfully synthesized from rice husk as agricultural waste.
The mesoporous silica nanoparticle's surface was modified by dielectric barrier discharge plasma as a green approach in uniform modification.
The surface modification was performed with two methods: i) direct mode, ii) direct hybrid mode.
The polymeric pH and temperature-responsive shell were grafted on the modified mesoporous silica nanoparticle surface by free radical polymerization technique.
The nanocarrier, which was modified by dielectric barrier discharge plasma, especially by the direct hybrid mode, had higher toxicity and apoptosis-inducing on the MCF-7 cell line compared with a free anti-cancer drug.
The surface modification stage by DBD plasma was performed in two methods: i) Direct mode and ii) Direct hybrid mode.纳米粒子的结构和物理特性特征为 XRD、FT-IR、FE-SEM/EDS、TEM、EDS、BET和Hss/sdestiasets-e-WestiDoxoricin(Dox)被开发为示范药,并调查体内Dex释放纳米载体生物相容性为HFF-2细胞线MT测试所接受为正常模数电池。
RMSN-D直接混合模式修改结果显示:MCF-7导出高吸附度:
/ahref='https/www.sciencedent.com/science/article/abs/pii/S1876107021007'DBD等离子直接表面修改双响应药送系统绿色方法,2021年台化工学院杂志https://doi.org/10.1016/j.jtice.2021.05.024.Der Beitrag Direct surface modification of mesoporous silica nanoparticles by DBD plasma as a green approach to prepare dual-responsive drug delivery system erschien zuerst auf Pharma Excipients.
Granular materials are part of the design, production and final products of different industrial sectors.可粉状流出性是制造和运输的一个主要题目,因为它与过程可行性密切相关。微粒素流不容易描述或量化,即使是干单片凝聚性简单例子 [.]
Der Beitrag
Granular materials are part of the design, production and final products of different industrial sectors.可粉状流出性是制造和运输的一个主要题目,因为它与过程可行性密切相关。尽管如此,颗粒物流并不容易描述或量化,即使是在干单差粒子简单例子中也是如此。可流性评估不是标准或正常化问题still, no测试无法预测处理期间所遇各种机械状态中的粉流行为。
Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent.聚合物非态配方目前最常用的是喷干热熔化或混合降水但这些技术挑战在于成功稳定s/www.pharmaexccidents.com/news/mesoporous-silica-poor-slipss/
Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent.聚合物非态配方目前最常用的是喷干热熔化或混合降水但这些技术在成功稳定穷玻璃原复合物方面有挑战,偏差硅状单片解析法稳定非晶状单片解析纳米尺度内
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Conclusions: Although polymeric-based amorphous solid dispersions are most prevalent, they may not be suitable for poorly soluble compounds that are also poor glass formers.显示溶性差和无变稳定性差的这些复合物对配制典型聚合基技术具有挑战性,因为可能分解和内分解归根结底,这些复合物在开发药剂期间可能增加失效风险,因为它们从生物可用性和不定稳定性角度构成风险在这次研究中,我们证明不良玻璃组成a相形之下,多思西里卡显示为此类API提供最优稳定化Therefore, mesoporous silica could be an attractive formulation technology to expand the formulation toolbox for APIs that are poor glass formers.
Article information: Daniel Joseph Price, Felix Ditzinger, Anita Nair, Jennifer Dressman, Christoph Saal, Martin Kuentz
Der Beitrag Mesoporous silica: a solution for amorphous stabilization of poor glass formers erschien zuerst auf Pharma Excipients.
To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed.进程参数包括mirNA类型、纳米粒子浓度、孵化温度和孵化时间,并调查 [...]
BeitragTo understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed.
Process parameters including miRNA type, nanoparticle concentration, incubation temperature and incubation time were investigated, as well as the potential competition for adsorption between different miRNA molecules.并探索蛋白质和粒子PEGILE微粒低富集度和生理温度都导致MIRNA吸附增加mirNA吸附率更高时,sup/sup/sup/LifeTechnology/Carlsbad/CA/USsnhsubjects.com/wp-content/uploads/2021/05/Isocript-Qivation-form-mirna-form-里弗罗博塞塔 EMLandry C.C.博特拉市mirna生物分子库罗纳对MesocorousSilicaNanop粒子的隔离和量化。 Nanoma料 2021 , 1196https://doi.org/10.3390/nano11051196
Der Beitrag Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica Nanoparticles erschien zuerst auf Pharma Excipients.
Breast cancer is the most frequent cancer among women and impacts over two million women each year.多类型抗癌药剂可供乳腺癌处理,但双叉素是最常用药之一异性硬化相关副作用如心机失灵和心律失常限制使用com/news/flic-acd-msn-doxoricin/
Breast cancer is the most frequent cancer among women and impacts over two million women each year.多类型抗癌药剂可供乳腺癌处理,但双叉素是最常用药之一异性硬化相关副作用如心机失灵和心律失常限制使用消除此限值并增强 doxorbis配方dexlQ/Calyx研究的目的是开发比DoxilQQPPPPPPPPPPPPPPPPPPPPPPPPPLAFPLAFPLA为了实现此目标,获取了小型单片西里卡纳米粒子(msns)并用叶酸并发并装doxoricin所获取纳米粒子完全特征化,并发验证,并显示pH依赖性药物发布剖面图。
Namep粒子抗癌活动详细调查ZR-75-1和T47-D乳腺癌细胞线流体显微镜和流细胞测量研究显示,小尺寸MSN可增强细胞对 doxorbic叶酸并发为此做出了实实在在的贡献。此外,两行细胞毒性研究也得出类似结果。主动锁定小型MSNs可能是增强dxoricin抗癌效果的有希望方法。
The increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics constitute a public health issue, since tuberculosis still constitutes the primary cause of death in the world due to bacterial infection. Mtb has been shown to produce membrane-derived extracellular vesicles (EVs) containing proteins responsible for modulating the pathological immune response after infection.esporySilicaNanop粒子s
The increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics constitute a public health issue, since tuberculosis still constitutes the primary cause of death in the world due to bacterial infection. Mtb has been shown to produce membrane-derived extracellular vesicles (EVs) containing proteins responsible for modulating the pathological immune response after infection.自然微粒被认为是开发新疫苗的有希望的替代方法。
然而,它们的使用因经观察无法复制准备而受到影响以开发纳米系统模拟由span类s制作的单细胞微粒mtb/span/ahrefssss/www.pharmaexsubjects.com/silica/设计并广泛描述这些新纳米系统,显示免疫元蛋白对MSNs表面的共价锚定效果。
mtb. 药学 2020 , 1212 1218https://doi.org/10.3390/pharmaceutics12121218
Der Beitrag Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis erschien zuerst auf Pharma Excipients.
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L.盖特纳市Silymarin行为弱酸并按生物药理药处理分类系统分类为IV类药物,拥有低溶性并生物可用性低研究范围是确定可能的配方策略 [.]
dserBeitrag
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L.盖特纳市Silymarin行为弱酸并按生物药理药处理分类系统分类为IV类药物,拥有低溶性并生物可用性低研究范围是确定Silymarin可能制定策略slimmari固体散射法并描述两种配方的物理化学和药物释放属性,两种配方包含两种多孔载波,即50%TweenQQ80对SyroidXDP3150配方释放作用微小有趣的是 TweenQQ80抑制内墙超载的能力是众所周知的容入前台为调整Silymarin生物可用性而不改变药物发布剖面提供契机半年稳定度研究(室温和40%RH)确认固态散射仍然是粉X射线分解和差分扫描分量分解均态化,Actone用于硅提取和制备固态散射science/abs/pi/S1773272900964目标s='blank' rel='noopener noreferr''>阅读此文章:valentyn Mohylyuk、Thomas Pauly、Oleksandrdovolnyi、Nathan Scott琼斯GavinPAndrews,药物提供科技杂志,第63卷,2021年https://doi.org/10.1016/jdst.20211216. Der Beitrag
The U.S.食品药管局强调按质量设计开发药产品临界物属性(CMAs)为QbD元素,对药厂和产品质量有影响药用药常像针形粒子晶化作用并影响过程,原因包括流性差、散度密度低和 [.]
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The U.S.食品药管局强调按质量设计开发药产品临界物属性(CMAs)为QbD元素,对药厂和产品质量有影响药用药常结晶成针形粒子并因易流性、低散密度和高压缩性能而影响过程。
挖掘小量材料并破针,多可用设备(摩塔-spetle、Krups研磨机)和定制研磨机在配制前经过评估处理后CIPRO粉末后用于制作MIT团队开发的微型片片制造单元片片由美国药店设置的药片关键质量属性后评估每种设备处理的药粉。
药粉属性与商业CIPRO相似针形晶体如何对药用操作产生作用,即使它规模微小,通过MIT团队设计研磨机处理粒子可获取适当的形状和后续流性.
Der Beitrag
In this study, an attempt was made to produce Liqui-Tablets for the first time.由环球Liqui-Pelets压缩完成动机将小说Liqui-Plet转换成Liqui-Tablet研究显示Naproxenliqui-Tablet uns
Der Betrag
In this study, an attempt was made to produce Liqui-Tablets for the first time.由环球Liqui-Pelets压缩完成动机将小说Liqui-Plet转换成Liqui-Tablet研究显示环球语言表可成功制作并快速释放毒品率(100%释放毒品~20分钟)在pH1.2下实现,naproxen不可解解解发现分解介质不同的pH会影响配方释放药的趋势,配方量不等液态车辆快速放药配方顺序视pH使用的不同而不同Neusilin US2的存在显示药物释放率显著提高,提高Liqui表强健度和硬性此外,X射线微摄影显示利基表组件统一分布加速稳定化研究显示可接受解析剖面值稳定化 。
tquat-at-206953>>iqui-Tablet-Nationaldoscript使用新开发Liqui-Mass技术 NOKHODCHIAspringer.com/article/10.1208/s12249-021-0143-w#citeas目标i>APSPharmSciTech 22, 85(2021年)。https://doi.org/1208/s1289-01943-w/pl=noopener noreferr>#AvicelPH101 所有其他试剂和溶剂都具有分析等级。Beitrag
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L.盖特纳市Silymarin行为弱酸并按生物药理药处理分类系统分类为IV类药物,拥有低溶性并生物可用性低silymarien-and/s'ss/www.pharmaexccepties.com/news/carrier-silymarin-and/
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L.盖特纳市Silymarin行为弱酸并按生物药理药处理分类系统分类为IV类药物,拥有低溶性并生物可用性低研究范围是确定Silymarin可能制定策略sillymarin固体散射法并描述两种配方的物理化学和药物释放属性,两种配方包含两种不同的多孔载波,即Syloid® XDP 3150-based formulations showed F2>50%.TweenQQ80对lilmarin发布作用可忽略不计,从s/www.pharmaexsubjects.com/product/syroid-xdp-3150/有趣的是 TweenQQ80抑制内墙超载的能力是众所周知的容入前台为调整Silymarin生物可用性而不改变药物发布剖面提供契机半年稳定度研究(室温和40%RH)确认固态分布仍然是粉X射线分解和差分扫描误差Actone同时用于Silymarin提取和制备固态散射sort/abs/si/S/17322472100964目标
The biocompatible nature of mesoporous silica nanoparticles (MSN) attracted researchers' attention to deliver therapeutic agents in the treatment of various diseases, where their porous nature, high drug loading efficiency, and suitability to functionalize with a specific ligand of MSN helped to obtain the desired outcome.mserBeitrag
The biocompatible nature of mesoporous silica nanoparticles (MSN) attracted researchers' attention to deliver therapeutic agents in the treatment of various diseases, where their porous nature, high drug loading efficiency, and suitability to functionalize with a specific ligand of MSN helped to obtain the desired outcome.
The application of MSN has been extended to deliver small chemicals to large-sized peptides or proteins to fight against complex diseases.最近,与MSN的配方研究进展到各种非常规药送系统,包括脂类药送系统、微孔药管药管药管药管药管药管药管药管药管低批量密度,下游处理保留微量结构,微量研究不足等重要问题对以微量单片为基础的先进药服系统的成功具有一定意义。
本审查旨在评价MSN应用高级药服系统以批判性分析MSN作用优于其他功能化聚合物最后,对基于MSN先进药服系统未来方向的展望与本平台现有挑战对比springer.com/article/10.1007s/mesoporous-silica-nanoprojects/
SYLOID® 244 has never been applied as a filler in composites with potential dental application.研究的目的是应用该硅化非修改和二分盐化形式,以不同质量比填充光线解密合成修改过程有效性通过使用拉曼光谱检验得到确认[…]
Der Beitrag Silica-filled methacrylic composites with extremely high compressive strength erschien zuerst auf Pharma Excipients.
SYLOID® 244 has never been applied as a filler in composites with potential dental application.研究的目的是应用s/www.pharmaex接受者.com/silica/silica/a/配有修改后非修改后
Der Beitrag Silica-filled methacrylic composites with extremely high compressive strength erschien zuerst auf Pharma Excipients.
This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT).NSC加载dUTNSC显微分解图确认存在 [.]
DerBeitrag This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT).NSC加载DUT(脂肪解析)并使用绑定技术分布在纳米级上。 NSC微模编译使用永久相图确认,而NDUT和脂绑定使用扫描电子显微镜确认差分扫描量度和X射线分解显示NSC无变性备妥全NSC极易流和增强DUT溶性,但在药物同质性方面没有显著差别NSC油量增加导致DUT溶解性增加ss/www.pharmaexsubjects.com/news/pmc-press-release-2020/并存4周60摄氏度稳定浮游狗实验显示,用NSC平板使用时DUT生物利用率提高NSC可使用平台开发方法以克服基于脂制备难药的技术和商业限制。 Download the full article here or read it here Article Information: Shin, H.-W.!金JE公园YJNanoporousSilica封装液化和吸附增强弱溶药综合体。 药学 2021 , 13 ,63https://doi.org/10.3390/pharmaceutics13010063 Der Beitrag Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs erschien zuerst auf Pharma Excipients.
Therapeutic proteins are widely used in clinic for numerous therapies such as cancer therapy, immune therapy, diabetes management and infectious diseases control.低稳定性和大容量蛋白质通常会损及它们的治疗效果因此,用受控方式向目标点提供主动式蛋白Nanoparticle […]
Der Beitrag Mesoporous Silica Nanoparticles for Protein Protection and Delivery erschien zuerst auf Pharma Excipients.
Therapeutic proteins are widely used in clinic for numerous therapies such as cancer therapy, immune therapy, diabetes management and infectious diseases control.低稳定性和大容量蛋白质通常会损及它们的治疗效果因此,用受控方式向目标点提供主动式蛋白纳米粒子系统为处理挑战提供了大有希望的方法偏差硅粒子对蛋白质传递特别感兴趣,因为它们极强生物兼容性、高度稳定性、僵硬框架、定义清晰孔状结构、易控形态学和可调和表层化学增强稳定性、增强活动性、响应释放和细胞内交付蛋白质系统审查MSN各种结构参数对蛋白质加载、防护和交付性能的影响并使用MSN实现细胞内交付、细胞外交付、抗菌蛋白实现、酶聚变和催解Continue on Mesoporous Silica Nanoparticles for Protein Protection and Delivery
Der Beitrag Mesoporous Silica Nanoparticles for Protein Protection and Delivery erschien zuerst auf Pharma Excipients.