The aim of the current study was to achieve a dry powder formulation of vancomycin by spray drying whilst evaluating the effect of pH and excipient type and percentage used in formulation on particle characteristics and aerosolization performance.优化配方应用D最优性设计s/www.pharmaexsubjects.com/news/vancomycin-spray-dried-powders/
The aim of the current study was to achieve a dry powder formulation of vancomycin by spray drying whilst evaluating the effect of pH and excipient type and percentage used in formulation on particle characteristics and aerosolization performance.优化配方应用D最优性设计a carbohydrate bulking agent (lactose, mannitol or trehalose) and a second excipient (hydroxypropyl beta-cyclodextrin or L-leucine) at pH 4 and 7.粒子物理化学特性(大小、形态学、晶状状态、残留水分含量)、稳定性和气溶化特征得到了调查。
+2前接收器增加微粒分数流速达60升/分钟exypryl bechodexrin显示比Llecine在喷雾性能方面的潜力更大3个月稳定存储40摄氏度和75%相对湿度显示优化配方保持良好物理稳定性,配方含17.39%氢丙基乙环丙菊酯,29.61%比pH4药量Use of two excipients including trehalose and hydroxypropyl beta-cyclodextrin with a total weight ratio of 47% relative to the amount of drug is appropriate for preparation of vancomycin dry powder formulation for inhalation.
Article information: (2021) Preparation and evaluation of vancomycin spray dried powders for pulmonary delivery, Pharmaceutical Development and Technology, DOI: 10.1080/10837450.2021.1915331
Der Beitrag Preparation and evaluation of vancomycin spray dried powders for pulmonary delivery erschien zuerst auf Pharma Excipients.
The current world health threat posed by the novel coronavirus disease of 2019 (COVID-19) calls for the urgent development of effective therapeutic options.CoVID-19需要像纳米反病毒之类可怕的路线纳米技术在消除纳米敌病毒方面作用非常关键 。虽然大量资源持续关注预防和护理问题,但我们希望 ss/www.pharmaexbenses.com/news/ updates-covid-19-inhalation-ephetics/
The current world health threat posed by the novel coronavirus disease of 2019 (COVID-19) calls for the urgent development of effective therapeutic options.COVID-19 needs daunting routes such as nano-antivirals.Hence, the role of nanotechnology is very critical in combating this nano-enemy "virus." Although substantial resources are under ongoing attention for prevention and care, we would like to start sharing with readers our vision of the role of inhaled nanomaterials and targeting systems that can play an important role in the fight against the COVID-19.
Highlights
Recent updates in COVID-19.
Pathogenesis and clinical presentation of COVID-19.
Corona virus and lungs.
Nanomaterials and COVID-19.
Inhalation therapeutics for COVID-19.
In this review, we underline the genomic structure of COVID-19, recent modes of virus transmission with measures to control the infection, pathogenesis, clinical presentation of SARS-CoV-2, and how much the virus affects the lung.除此以外,本审查还讨论了最近以纳米材料技术方法价值为主管理COVID-19的治疗方法。
本审查还侧重于安全高效地提供使用设计纳米载体的可用定向治疗法此外,主动锁定通过定制悬浮纳米粒子表达于corona病毒表面的某些特定受体的有效性和可用性被操纵在这次审查中还强调吸入药的作用,包括抗病毒药和改用药以消除相关肺病和开发疫苗效率Moreover, the inhalation delivery safety techniques were also highlighted.
Download the full article as a PDF here or read it here
Article information: Ahmed A.H.AbdellatifHeshamMTawfeek、Ahmed Abdelfattah、Gaber El-Saber Batiha和Helal海塔CoVID-19最新更新,重点是吸入治疗方法:Nano结构化目标系统,
药送科技杂志,第63卷,2021年https://doi.org/10.1016/j.jddst.2021.102435.
Der Beitrag Recent updates in COVID-19 with emphasis on inhalation therapeutics: Nanostructured and targeting systems erschien zuerst auf Pharma Excipients.
DerBeitrag
Jermain Stephen A汤普森、Hirosuke Furuta、Mamoru福田和Robert OWilliams IIIBR/Pharmaceutics 2020, XXXX, XXX, XXX-XXX,
Publication Date:December 8, 2020
https://doi.org/10.1021/acs.molpharmaceut.0c00811
KEYWORDS: amorphous solid dispersion, hot melt extrusion, mesoporous silica (Syloid XDP 3050), HPMC (Affinisol HPMC HME 15LV, Affinisol HPMC HME 100LV, Affinisol HPMC HME 4M), Itraconazole (ITZ), Lactose monohydrate (InhaLac 230), Croscarmellose sodium (KICCOLATE)
Der Beitrag Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica Enhance Dissolution Performance erschien zuerst auf Pharma Excipients.
Ideally, inhaled therapy is driven by the needs of specific disease management.龙生物界面吸入器性能允许最优提供治病药剂吸入气溶胶产品由治疗剂、配方和装置组成每种构件的制造规范及其组合允许准确和可复制控制 [.]
Der Betrag
Ideally, inhaled therapy is driven by the needs of specific disease management.龙生物界面吸入器性能允许最优提供治病药剂吸入气溶胶产品由治疗剂、配方和装置组成每种组件的制造规范集成性能可准确复制控制质量度量和体外性能产品变量与病人变量并发,包括吸入器使用协调技巧、固有肺生物、疾病和随之产生的肺功能都有助于药安全并产生效果。
持续研究似能提供新洞察力 精确预测肺部的药效干扰性创新是上世纪末吸入药交付研发的特点新千年头十年推出的新吸入产品相对较少,但显然前些年探索使商业上成功技术成熟。
其中一些开发可追溯到原创领域前期,而另一些则反映基础和计算机科学及工程其他领域的进展选择生物和技术进步时,会反射可能影响未来临床和监管考量。Continue on emerging trends in inhaled drug delivery
Keywords: Aerosols, Inhalers, Lungs, Particles, Particle size, Biopharmaceutics
Der Beitrag Emerging trends in inhaled drug delivery erschien zuerst auf Pharma Excipients.
We investigated the feasibility of preparing high-potency tacrolimus dry powder for inhalation using thin film freezing (TFF).使用超快速冷冻可增加药载达95% 并同时保持良好的喷雾性能药加载影响特定表面积和湿度吸附TFF配方,但没有影响化学 [.]
Der Beitrag We investigated the feasibility of preparing high-potency tacrolimus dry powder for inhalation using thin film freezing (TFF).使用超快速冷冻可增加药载达95% 并同时保持良好的喷雾性能药加载影响特定表面积和湿度吸附TFF配方,但没有影响化学稳定性、物理稳定性和解析tacrolimus.
Article Information: Sawittree Sahakijpijarn, Chaeho Moon, Xiangyu Ma, Yongchao Su, John J.Koleng, Andrei Dolocan, Robert O.spanQspan类表示'文本名'em>国际药理学杂志,2020. Beitrag
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now using new drug delivery formulation technologies to increase niclosamide's absorption into the body, designing the drug so that it can […]
Der Beitrag New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19 erschien zuerst auf Pharma Excipients.
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now using new drug delivery formulation technologies to increase niclosamide's absorption into the body, designing the drug so that it can be inhaled directly into the lungs, which could prove effective at treating and preventing serious COVID-19 virus symptoms in patients.
A collaborative team of researchers in UT Austin's Division of Molecular Pharmaceutics and Drug Delivery, led by Robert O.Williams III和HughD斯密思正在调查各种药送方法 将现有药改用更有效形式团队先关注niclosamide 最近确认显示COVID-19受感染细胞抗病毒效果单片比氯仿、洛皮那维尔和remdevir等其他药更有药效,并由于它作为抗病毒药的活动,它可以证明是治疗病毒的选项。
使用单片有效处理的一个问题是口服时吸收能力差药性能受限表示药很少或根本没有到达受感染目标点研究团队开发新药提供技术以克服这些限制团队提高药物显性溶解性并正在进行口服研究。
团队中包括Ashlee布鲁诺扎里Warnken、Chaeho Moon和Miguel Jara Gonzalez开发出内吸式鼻吸剂以保护和处理呼吸道感染方式,包括微量晶体干粉和薄膜冷冻生成的不定brettle矩阵粉Since COVID-19 has shown to be particularly damaging to the lungs, delivering an antiviral directly to the site may prove an effective prevention strategy and provide additional treatment options.
See the full University of Texas press release
See also a microneedles approach to coronavirus vaccines
Der Beitrag New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19 erschien zuerst auf Pharma Excipients.
Respiratory diseases account for a very significant portion of worldwide morbidity and mortality but to-date only a limited number of therapeutics are available for direct delivery via inhalation.纳米技术提供一系列潜在效益,促进定向交付/协同交付现有治疗剂,支持提供更先进生物处理方法,例如proteins, […]
Der Beitrag Respiratory Drug or Vaccine Delivery Using Nanoparticles erschien zuerst auf Pharma Excipients.
Respiratory diseases account for a very significant portion of worldwide morbidity and mortality but to-date only a limited number of therapeutics are available for direct delivery via inhalation.纳米技术提供一系列潜在效益,促进定向交付/协同交付现有治疗剂,支持提供更先进生物处理方法,例如蛋白质和基因药理.
###可吸入纳米医学的临床和商业翻译并非无关小事,并提出了重要的配制、制造、评估和管理挑战sprianger.com/captce/10.10073-030-35910-2_6et al.2020年 吸食药/Vaccine使用Nanop粒子提供.in:MutitilP.Kunda南浦粒子中药物和生物运算AAPS药理学丛书第41卷Springer, Cham
Der Beitrag Respiratory Drug or Vaccine Delivery Using Nanoparticles erschien zuerst auf Pharma Excipients.
Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to enhance therapeutic activity.估计只有10-15%的药物深入肺部,而20%的药损入Orpharyngeal领域和 [.]
derBeitragAlthough dry powder inhalers (DPIs) have attracted great interest compared to nebulizers and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to enhance therapeutic activity.估计只有10-15%的药深入肺部,20%的药损入复用领域,65%没有从载体释放药片在病人吸入气溶化期间散落在空气中的可能性应优化化 。
无载量粒子的肺沉降率较高,主要是喷雾干燥产生的,原因是载体和药间非分片作用力,以及粉状均匀化和喷雾化效果提高。此外,二三活性成份关联同粉似乎更容易本审查侧重于新型无载粒子,以甘核为特征,由喷雾干燥生成的波纹贝层组成生成这些粒子的所有前接收器解剖并分解物理化学特性(Peclet数、玻璃切换温度)与粉末的肺沉降能力相关联。
特别注意形态学(特征由曲面交错)和肺沉降性能之间的关系The understanding of the closed relation between particle material composition and spray-drying process parameters, impacting the final powder properties, could help in the development of promising DPI systems suitable for local or systemic drug delivery.
Article Information: Anna Lechanteur and Brigitte Evrard!药理学上 < span>stimess/sray-drying-freed-dpi/
Background and objective: Dry powder inhalation provide many promising features for drug delivery to the pulmonary system, such as localization of drug within the lungs, drug retention in the respiratory tract, and reduced systemic toxicities.spray-drivesomes/'spray-drivatepliotose研究碳水化合物作用和富集量研究 erzuerta
Background and objective: Dry powder inhalation provide many promising features for Conclusion: Stable spray-dried liposomes were manufactured using sugars as carriers. See the full research paper as PDF: Spray-dried liposomes – A study of the effect of carbohydrate carrier and concentrations on liposome size and drug entrapment Hussein, N.2019年spray-dripotoses研究:carbrogate载波和浓度对脂质尺寸和药绑定物的影响/i>/i>,23 /i>/i>(3),345-353. Building on a long and well established history of supplying world class pharmaceutical grade lactose, film coatings, and tableting systems, Kerry introduces Aero Flo® Inhalation lactose, designed to meet the growing demand for lactose that is suitable for developing dry powder inhalers.arerag Building on a long and well established history of supplying world class pharmaceutical grade lactose, film coatings, and tableting systems, Kerry introduces Aero Flo® Inhalation lactose, designed to meet the growing demand for lactose that is suitable for developing dry powder inhalers. Aero Flo® Brand Inhalation Grades of lactose have been specifically developed for use in dry powder inhalers (DPI) for pulmonary delivery of pharmaceuticals.粒子大小和晶体形态在这些应用中发挥着关键作用,将API送入肺部,同时不干扰药物本身的吸收 。 Kerry确认,这些都是重要考虑因素,应计入乳糖制造中,正因如此AeroFloIn addition, Kerry's unique processing maintains the crystallinity of the lactose, which can be a critical factor when formulating DPI's. See more on the Kerry excipients product range Interested to get to know more information on Aero Flo® Inhalation lactose? Der Beitrag Kerry Launches Aero Flo Brand Inhalation Grades of Lactose at DDL 2019 erschien zuerst auf Pharma Excipients. Background The use of amino acids as excipients is a promising approach to improve the physical stability and powder dispersibility of spray-dried powders for inhalation.本研究的目的是调查不同氨基酸对喷雾驱动非态粉末的稳定效果,以Simvastatin为模型复合方法 Beitrag The use of amino acids as excipients is a promising approach to improve the physical stability and powder dispersibility of spray-dried powders for inhalation. The aim of this study was to investigate the stabilizing effect of different amino acids on spray-dried amorphous powders for inhalation using simvastatin (SV) as a model compound. Two hydrophobic amino acids (leucine, LEU and tryptophan, TRP), and one hydrophilic amino acid (lysine, LYS) were spray dried from 1% (w/v) solutions with SV at a molar ratio of 1:1 into dry powders for inhalation.扫描电子显微镜(SEM)、X射线粉分片(XRPD)、差分扫描量测法(DSC)和减缩总反射法Fourier变换红外光谱镜(ATR-FTIR)用于描述喷雾式粉的形态学、固态形式和可能的分子间交互作用X射线光电分光镜分析粒子表面化学组成干粉在受控条件下存储时对物理稳定性进行了检验。使用下一代撞击器评估火药体内喷雾性能。 Read more on amino acids as stabilizers Author links open overlay panelWangdingLu, ThomasRades, JukkaRantanen, Hak-KimChan, MingshiYang https://doi.org/10.1016/j.ijpharm.2019.118724 Der Beitrag Amino acids as stabilizers for spray-dried simvastatin powder for inhalation erschien zuerst auf Pharma Excipients. Non-segregating ordered powder mixtures constituted by a coarse carrier fraction and finer components are at the basis of dry powders for inhalation pharmaceuticals.估计加载容量,即运量粒子上有多少罚款,对通过可复制和可支付制造过程提供产品质量至关重要。s/www.pharmaexbenses.com/exbensive-for-inhalation/loading-cap-dpi-formation/
Non-segregating ordered powder mixtures constituted by a coarse carrier fraction and finer components are at the basis of dry powders for inhalation pharmaceuticals. The estimation of the loading capacity, i.e.运量粒子上有多少罚款,对通过可复制和可支付制造过程提供产品质量至关重要。基于筛分析、光学显微镜和火药床渗透性组合方法,量化装药容量并理解罚款行为,混合过程的影响也得到了调查。 不同方法提供的结果一致,证明方法准确并可复制The effect of different mixing parameters and equipment on the loading capacity is also discussed. Full article as PDF: Quantifying the loading capacity of a carrier-based DPI formulation Andrea Benassi, IaIlaria Perazzi, Roberto Bosia, Ciro Cottini, Ruggero Bettini Der Beitrag Quantifying the loading capacity of a carrier-based DPI formulation and its dependence on the blending process erschien zuerst auf Pharma Excipients. Localized aerosol delivery of gene therapies is a promising treatment of severe pulmonary diseases including lung cancer, cystic fibrosis, COPD and asthma.吸食药管理多重好处,包括提高患者可接受性与合规性喷干粉配方优于解决办法,因为它们增强稳定性 [.] Localized aerosol delivery of gene therapies is a promising treatment of severe pulmonary diseases including lung cancer, cystic fibrosis, COPD and asthma.吸食药管理多重好处,包括提高患者可接受性与合规性喷干粉配方优于解决办法,因为它们增加稳定性和储存寿命喷雾干燥最优性能允许深度肺沉降 。 本项研究优化多片喷雾相关参数此外,还调查了生成NEM粉末的初始矩阵对核酸生物活动的影响和回收嵌入纳米粒子的能力研究表明生物活性和核酸完整性经喷干后得到维护,多片从干粉中重构扫描电子显微镜显示松散粒子介于1-5m之间,而manitol配方面平滑并由更多定义粒子组成。细胞摄取和移植肺膜细胞研究表明,再散口粒子与非喷干多片相似或优于多片开发出一种方法量化喷雾干燥后聚合物和核酸损耗,以确保所有 in试管 实验使用等量核酸检测结果确认,喷干NEM配方中含核酸的特征已知最适于吸入理疗. 
drug delivery to the pulmonary system, such as localization of drug within the lungs, drug
retention in the respiratory tract, and reduced systemic toxicities.研究旨在
编译含有沙丁胺醇硫酸干粉,使用喷干和
研究载体类型和集中对脂性尺寸和药绑定
的影响carbohryate载体: lactose、trehose、sucrose和
manitol1:6或1:10(w/w)脂乘比单编入
滑动配方并用BüchiMini-SprayDryerB-290干/p>
+1.14%)>manitol(50.16+0.80%)视载量类型
和脂对载量比而定,用乳糖和manitol的脂体大小显著增加
(P <0.0001和P=0.0027),而用trehoose
和sucrosse的胶体大小与控制配方
相比变化幅度较小(P>0.05)(3.6m+0.24)。1:10公式化时,用manitol(P <0.001)和sucrose
formulations was 20.74±1.78% for sucrose, 35.59±2.42% for trehalose, 67.21±1.89 % for
lactose, and 80.84±3.64% for mannitol.
The findings of this study have demonstrated the potential using of carbohydrate carriers to
increase the physical stability of liposomes during the drying process, and trehalose can
offer formulations with most desirable characteristics, while mannitol showed the least
benefits
Background
Objectives
Methods
Read the article
https://doi.org/10.1016/j.powtec.2019.08.109
Der Beitrag Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles erschien zuerst auf Pharma Excipients.
This chapter describes the application of lactose as excipient in the pharmaceutical industry.约60+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++Lactose可有数项函数分解形式:作为填充器提供大片类药片,并绑定 [.]