The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing.双螺旋湿粒子选择应依赖科学方法实现高效配方开发当前研究识别影响绑定效果的绑定属性.
/derBeitragThe suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing.双螺旋湿粒子选择应依赖科学方法实现高效配方开发因此,当前研究确定绑定物属性影响绑定物有效性,湿粒化过程高度易解模型前接收者(manitol)提高绑定效果与绑定特性快速激活相关联(即快速绑定分解动能加低粘度属性和绑定器净湿性属性)。粘合物属性对难解配方粒子过程的影响(二叉酸盐)先前曾调查过,这使得当前研究中能对两种配方进行全面比较,重点是绑定物选择比较显示,绑定物属性对引导绑定物选择很重要,因配方可溶性而异。当前研究中关键绑定属性识别可合理高效选择双片组粒化可溶性差解性配方Binder加法证明对低溶性配方特别有价值 。
Existing oral or injectable antipsychotic drug delivery strategies typically demonstrate low bioavailability to targeted brain regions, incentivizing the development of alternative delivery strategies.通过鼻腔送货绕过多屏障进入脑部,但需要带药工具非常特殊性能有效sNPs和CMCh高亮体液凝胶
DerBeitrag Existing oral or injectable antipsychotic drug delivery strategies typically demonstrate low bioavailability to targeted brain regions, incentivizing the development of alternative delivery strategies.Delivery via the nasal cavity circumvents multiple barriers for reaching the brain but requires drug delivery vehicles with very specific properties to be effective. Bulk hydrogels made from SNPs and CMCh can be formed in situ within the rat nasal cavity. Hydrogels are sprayable, hydrolytically-degradable, and mucoadhesive. PAOPA-loaded hydrogels alleviate behavioural abnormalities in a pre-clinical model for at least 72h. Behavioural abnormalities are alleviated at up to 75% lower drug dose versus conventional delivery. Herein, we report in situ–gelling and degradable bulk nanoparticle network hydrogels consisting of oxidized starch nanoparticles (SNPs) and carboxymethyl chitosan (CMCh) that enable intranasal delivery via spray, high nasal mucosal retention, and functional controlled release of the peptide drug PAOPA, a positive allosteric modulator of dopamine D2 receptor.PAPA加载SNP-CMCH水凝胶可缓解不良症状,如与精神分裂相关的行为异常MK801诱发小鼠精神分裂模型低药用量(0.5 mg/kg)常规PAPA通过渗透式管治方式需要两次PAPA剂量实现只持续数小时的治疗效果。 Text提供通过最小入侵式管治方式大幅下降复用频率和全片药量(并因此产生副作用)的可能性。 Der Beitrag In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network hydrogels for the intranasal delivery of an antipsychotic peptide erschien zuerst auf Pharma Excipients.
Highlights
The encapsulation of nanoparticles within microparticles designed for specific delivery to the colon is a relevant strategy to avoid premature degradation or release of nanoparticles during their passage through the stomach and upper gastrointestinal tract (GIT), allowing the targeted delivery of chemotherapeutics to the colon after oral administration.s/www.pharmaexbenses.com/chitosan/gastro-deport-nanopartics/
The encapsulation of nanoparticles within microparticles designed for specific delivery to the colon is a relevant strategy to avoid premature degradation or release of nanoparticles during their passage through the stomach and upper gastrointestinal tract (GIT), allowing the targeted delivery of chemotherapeutics to the colon after oral administration.在此,我们设计口交系统 实现目标释放结核从这个意义上讲,千兆粒子封装5-氟极素(5-FU)并嵌入变换星系和分光粒子(RS/P)后开发并沿鼠标GIT流出时使用多光学成像监听体外释放研究显示,CSNP嵌入RS/P微粒子可促进对5U释放率的更大控制,酸介质大减53%,可复制口服后胃部发现的酸介质CSNP体积分布评价显示鼠标GIT分布模式快速清除,即CSNP流转时间比CSNP加载RS/P微粒短单单CSNP显示非特定吸入流与相关肾积,而CSNP加载RS/P微粒则没有在血液或主要清除器中观察到重大积聚这表明结肠微生物对RS/P的具体可分解性似乎对提高CSNP保护至结肠释放具有决定性作用,防止意外吸入流和主机口服管证明RS/P微粒子作为向结核提供药载纳米粒子的潜在载体的概念,这项工作将有助于开发横切癌症理疗口系统ahrefss/www.scient.com/science/abs/pi/serBeitrag
Felines may find orally administered medicines unpalatable, thus presenting a problem in the treatment of chronic conditions such as hypertension, a commonly diagnosed condition in felines requiring daily administration of medication.相关例子有安卓比拉特语,猫很难接受配方需要开发 [.]
DerBeitrag Felines may find orally administered medicines unpalatable, thus presenting a problem in the treatment of chronic conditions such as hypertension, a commonly diagnosed condition in felines requiring daily administration of medication.相关例子有安卓比拉特语,猫很难接受配方需要开发易管理并掩码药品味的fline特效方法,从而加强所有者对治疗的承诺和伴生动物相关治疗结果。
此外,板块质量一致性、内容一致性、板块直径、厚度和硬性等表列参数都令人满意。本研究显示,amlodipine含L-lysine微型槽可提高可达性,转而支持产品可接受性和管理易易易性这些数据通过产品差异化和伴生动物市场竞争优势对猫类和其他兽类口服药产生影响研究还概述了电子语言在兽医领域选择配方工具的使用.
/a/hrefs/www.pharmaexbens.com/wp-content/uploads/2020/10/developation-and-Evaluation-of-Tailored-Amlodipine-Mini-Tablets.pdf'目标='#blank'rel=noopernoreferr'>Abdelhakim阁下克雷格DQM巴克,S.A.eline自定义Amlodipine微信表开发与评价 20 , 12 ,917.p>Der Beltrag
The presence of different excipient types/brands in solid oral dosage forms may affect product performance and drug bioavailability.理解超异性(物性变化)、变异(初始量变化)和互换性(使用不同前端类型并使用相同功能)对口服药性能的帮助案例研究:超级寄生虫 erschienzufta
The presence of different excipient types/brands in solid oral dosage forms may affect product performance and drug bioavailability.理解超异质变异(物性变异)、变异(初始量变异)和互换性(使用不同前端类型并使用相同功能)对口服药性能将有利于开发稳健最终用量表。
计算式生物介质用于评估胃肠条件对前台对药物显性溶性的影响对大多数复合物而言,除高离子化复合物案例(药溶性显著下降)和/或聚合/沉降溶性复合物案例(药溶性显著提高)外,在超分辨性并没有发现药物显溶性变化多变量数据分析确认生物药理学因素影响初始性能构建路径图显示超分量可能低风险前接受者单靠药溶性对口服药性能的影响超分量活动因其对片片分解的影响仍可能成为口服生物利用率风险Download the publication as pdf by clicking on the image
Der Beitrag Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties.案例研究:超级寄生虫 erschienzufta
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design space.starch粒子百分比(30-50%,w/w),分解片类分解片类的分解分解片类的分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片类/分解片
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design space.starch粒子百分比(30-50%,w/w)、分解属性类型(Ac-di-sol,Explotab,Polyplasdone)、外部分解百分比(4-8%,w/w)和压缩力百分比(5-15kN)为评价因子(24运行+9中心点=33实验),表硬性、易碎性分解时间为研究表属性(响应)。
starch粒子编译含有微晶素素、乳糖、内部分解物(8%)和聚聚苯二烯K-30(4%)的粒子均用湿粒子制成粒子、粒子(700-1000m)和外部分解混合并压缩成微片(17.1毫米长,8.2毫米宽)。 对DE结果计算效果的评估显示,要产生高硬度、低易碎性(<1%)和短分解时间(<3分解时间)片片需 starch粒子和高压缩强度低集中聚plandone粒子最小孔易易易解化,DE研究中反映了这一点,DE研究中含有聚plandone片子比ac二溶和Explatab平板子硬易解解解速度快Montecarlo最优因子设置模拟(30% starch粒子、4% Polyplasdone和10kN压缩力)显示,强健系统组成,因为所有响应均低超限概率验证设计空间(最优设置)显示,通过DOE模型预测的结果与观察实验数据完全相关hrefs/www.scient.com/science/disterns-in-mups/
A novel approach for drug design based on the oral carbapenem analog tebipenem pivoxil (TP) has been proposed.ebipenpivyl-e-cerodexrin综合体(TP-D-CD)形成后,TP物理化学特性发生变化,这对规划开发创新药方并修改生物活动都意义重大 [.]
A novel approach for drug design based on the oral carbapenem analog tebipenem pivoxil (TP) has been proposed.ebipenempivoxil-Di-Choledexrin综合体(TP-D-CD)形成后,TP物理化学特性发生变化,这对规划开发创新药方和修改研究送送系统生物活动剖面意义重大。光谱分光谱和热方法确认TP已入二环极素数
hrefs/Journals.plos.org/plosone/article?id10.1371/Journal.bone.0210694yclodexrins多功能前接收者:SPLOS PONE14(1):e0210694https://doi.org/10.1371/journal.pone.0210694
Der Beitrag Cyclodextrins as multifunctional excipients erschien zuerst auf Pharma Excipients.
Implication of Quantitative Selection of Each Excipient in Product Development Excipients' role in designing different dosage forms does not require any introduction.以上这些添加物与药理活性物质并发增加这些特性的主要目的是增加大数配方并传递所期望的[.]
Beitrag Excipients' role in designing different dosage forms does not require any introduction.以上这些添加物与药理活性物质并发增加这些特性的主要目的是增加大片配方并传递期望属性始发者像药物一样,需要验证和标准化下一章简单介绍不同用量表使用前接收者,包括固态用量表、液态用量表和半固态用量表计药先进配方领域的持续开发,我们还覆盖纳米化前接收者。 Implication of Quantitative Selection of Each Excipient in Product Development
Der Beitrag Current Developments in Excipient Science – Implication of Quantitative Selection of Each Excipient in Product Development erschien zuerst auf Pharma Excipients.
The objective of the current work was to enhance the critical attributes of rapid orally disintegrating tablets (RODTs) manufactured by direct compression technique to have sufficient mechanical strength and fast disintegration time using partially pre-gelatinized starch.双阶层(32)应用全因子设计检查 主和交互效果 [.]
DerBeitragThe objective of the current work was to enhance the critical attributes of rapid orally disintegrating tablets (RODTs) manufactured by direct compression technique to have sufficient mechanical strength and fast disintegration time using partially pre-gelatinized starch.二分三分三分全分设计测试独立变量的主要和交互效果局部预化星级X1和微晶素纤维素级X2 关于RODT特征制作片片测试权重一致性、机械强度、分解时间和体外释放药结果显示,人工RODT编译时使用USP要求此外,ANOVA分析显示PPGS级和CCM级对依存响应有重大影响(PQQ0.05)。此外,开发RODT显示在分解时间有良好的内插/插接数字优化使用可取性方法还用于优化独立变量发现高期望值(0.917)可在低PGS(6.66%)和中CCC(37.71%)实现Finally, it could be conclude that PPGS is a potential candidate for production of RODTs of high mechanical strength and very fast disintegration time.
Der Beitrag Application of design of experiment approach for investigating the effect of partially pre-gelatinized starch on critical quality attributes of rapid orally disintegrating tablets erschien zuerst auf Pharma Excipients.
The use of natural polymer as excipients in pharmaceutical sector is expanding day by day.低成本安全分解是导致它们不同于其他来源的主要原因自然源有多种种类和特征药产品中可以多用作为前接收者为理想目的服务[.]
Beitrag
The use of natural polymer as excipients in pharmaceutical sector is expanding day by day.低成本安全分解是导致它们不同于其他来源的主要原因自然源有多种种类和特征药产品中可以多用作为前接收者为理想目的服务文章的目的是透视自然聚合物应用问题。
Beitrag < a rel='nof'href='https//www.pharmaextips.com/organic-stemps/aplial-sugars/粒子增密度取决于各种配方和过程变量,包括关键配方前接收器的物质属性,如绑定器已知绑定物属性对微粒生长速度和广度的影响 [.]
derBeitrag 粒子增密度取决于各种配方和过程变量,包括关键配方前接收器的物质属性,如绑定器已知绑定物属性对微粒生长速率和广度的影响和湿粒化过程的密度可以是特定或不可知性对特定活性药素成份或药产品配制绑定属性和流程变量(如加法模式)对HSWG进程和产品性能的影响可以实验式探索或通过硅建模和模拟探索介绍实例和案例研究使用实验法和建模法对过程性能的影响This chapter demonstrates the essential role of combining multiscale models such as the mechanistic, first principles-based particle-level models, and process models with experimental observations to fully understand and characterize the role of binder attributes on the process outcomes. Read more on wet Granulation in the Handbook of Pharmaceutical Wet Granulation Der Beitrag Effect of Binder Attributes on Granule Growth and Densification erschien zuerst auf Pharma Excipients.
13.2018年8月3D打印是一种添加式制造技术,能从数字设计中产生各种3D药产品、医疗设备、组织和器官FDA首批三维药产品Spritams/www.pharmaexsubjects.com/news/city-of-3d-print- withdosages-a-new-perpsiew-for-mode-Hecuration/
Der Beitrag Integration of 3D printing with dosage forms: A new perspective for modern healthcare erschien zuerst auf Pharma Excipients.
292017年1月ABSTRACT口服复合物管理这项工作旨在开发并描述基于 starch和Gelatin的口服分解薄膜维他命C载体s/www.pharmaexcceptips.com/news/gelatin-and-preglati
Der Beitrag Gelatin and pregelatinized starch orally disintegrating films: Properties and stability of vitamin C erschien zuerst auf Pharma Excipients.