Glycerides are the main components of oils, and fats, used in formulated products in the food and cosmetic industry as well as in the pharmaceutical product industry.然而,关于甘化物化学组成分析的现有文献有限。s/www.pharmaexccepties.com/nmr/
Glycerides are the main components of oils, and fats, used in formulated products in the food and cosmetic industry as well as in the pharmaceutical product industry.然而,关于甘化物化学组成分析的现有文献有限。缺乏完全化学剖析甘化物的适当分析方法是理解和控制处理、配制和存储期间化学成分变化的瓶颈之一。
Thus,本研究的目的是开发免标质子核磁共振法以同时量化甘化物的不同成分qHNM方法开发是为了量化单片、二片和三片位置异构物自由脂肪酸并含甘醇开发方法的精度、精度和强度得到了评价,并被认为适合对五批市场前接受者进行量化分析。
springer.com/ahrf=https://doi.org/10.1208/s12249-020-01883-x
Der Beitrag Quantitative Chemical Profiling of Commercial Glyceride Excipients via 1H NMR Spectroscopy erschien zuerst auf Pharma Excipients.
Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides.近些年来,从植物中提取的3000种基本油中,只有300种基本油在各个领域应用方面得到了广泛关注。[.]
Der Beitrag Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides.近些年来,从植物中提取的3000种基本油中,只有300种基本油在各个领域应用方面得到了广泛关注。在这次审查中,我们讨论与EO有关的主要生物活动,如杀菌剂、杀菌剂、杀菌剂、杀菌剂、杀菌剂、杀菌剂、杀菌剂、杀菌剂、杀虫剂、杀寄生物剂和细胞毒剂各种运送基本油路以及诸如高挥发性、低稳定性、渗透性、生物可用性、低水溶性、易氧化性、分解性、照片敏锐度和皮肤刺激等基本油问题也得到强调。此外,不同纳米封装系统建议解决上述问题的战略其中包括聚合纳米载体、脂基纳米载体和分子复合体相信纳米封装基础油将提高它们的治疗活动与交付量 。
Science Vision – Volume 20, issue 2, pages 54–71 – 30 June 2020 https://doi.org/10.33493/scivis.20.02.01
Keywords: Biological activity, cytotoxic, antiviral, antiparasitic, nanocapsulation,Polymer-based nanocarriers, Nanocapsules, Nanoparticles, lipid-based nanocarriers, Lauroglycol® FCC, Capryol® 90, medium chain triglycerides, paraffin oil, 2-octyldodecanol, Miglyol® 812, Transcutol® HP, Labrafil Lipofile® WL 1349, Labrafac® PG, Polyvinyl alcohol, Solutol® HS15, polyglycerol methyl glucose distearate Pluronic® F68 (poloxamer 188), Pluronic® F127, Tween 20, Tween 40, Tween 80, Phosphatidylcholines, phosphatidylethanolamines, Gelucire® 50/13, Polysorbate20, Polysorbate80, Polyoxy60, castor oil, glycerine, PEG300, PEG400, Polyene glycol, Poloxamer
Der Beitrag Essential oils: a review on their salient biological activities and major delivery strategies erschien zuerst auf Pharma Excipients.
Compritol® 888 ATO is a fine white powder, insoluble in water and organic solvents.无味无味用作润滑剂、保护敏感药物涂层代理物、口味遮罩和矩阵原持久释放com/news/compritol-88-ato/
Compritol® 888 ATO is a fine white powder, insoluble in water and organic solvents.无味无味It is used as lubricant, coating agent for the protection of sensitive drugs, in taste masking and as a matrix former in sustained release.
Compritol® 888 ATO is an ester of mono-, di- and triglycerides, the die-ester fraction is predominant (40 – 60%).由植物来源(图3-1)的甘油和脂肪酸C22组成Gattefossé production process ensures Compritol® 888 ATO batches have high reproducibility and constant composition.
Compritol® 888 ATO particles have a spherical shape (Figure 3-2), a mean particle size of 50 μm and a narrow size distribution.
DOWNLOAD THE FULL BROCHURE HERE
Main features of Compritol® 888 ATO in SR matrices
Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent.
- Drug release from a Compritol® 888 ATO matrix is diffusion controlled and not driven by swelling and erosion.方便简单产品设计,包括直接调试药物释放和高可复制性。 A CompritollIt makes biopharmaceutically robust tablets.
- Versatile use of Compritol® 888 ATO in many processing techniques favors product optimization and provides scope for innovation in solid oral dosage form development.
Der Beitrag Developing sustained release tablets with Compritol® 888 ATO erschien zuerst auf Pharma Excipients.
The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl dibehenate (Compritol® 888 ATO) and dibasic calcium phosphate anhydrous (Fujicalin®) as carriers for pediatric applications.extlipsi-lipidic-pllet/'Hot-meltexible应用研究活性物质状态
BeitragThe current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl dibehenate (Compritol® 888 ATO) and dibasic calcium phosphate anhydrous (Fujicalin®) as carriers for pediatric applications.
The extruded lipidic pellets were physicochemically characterized in order to examine the state of the active substance within the extruded formulations where Df-Na was found to retain its crystallinity but partially solubilized by glyceryl dibehenate.快速Df-na粒子解析率在胃道评估(pH1.1和模拟气流pH1.6)和肠状条件评估(pH5.5)调查酸奶、苹果酱、马铃薯泥和hypromeloess 2910等食品等级的影响。
Extorane此外,长期加速存储显示对粒子释放毒品有影响。hrefs/www.scient.com/science/abs/bmel-extlidic-pell/
In last two decades, the lipid nanocarriers have been extensively investigated for their drug targeting efficiency towards the critical areas of the human body like CNS, cardiac region, tumor cells, etc.由于弹性和生物兼容性,基于脂质的纳米载体,包括纳米仿真机、亲脂机、单片机和NLC等各种纳米载波系统都多加注意 [.]
Der Betrag
In last two decades, the lipid nanocarriers have been extensively investigated for their drug targeting efficiency towards the critical areas of the human body like CNS, cardiac region, tumor cells, etc.由于弹性和生物兼容性,基于脂质的纳米载体,包括纳米仿真机、亲脂机、单片机和NLC等各种纳米载体系统对脑生物活性有了极大关注。
跨异脂纳米载体NLC仍然是安全性最强、稳定性强、生物兼容性强和成本效益高并封装效率高的药载系统向大脑提供药对科学家来说始终是一个挑战性问题,因为大脑结构复杂并有各种屏障机制。应用合适的纳米载体系统并使用任何其他药管路线,如鼻对脑提供药可克服障碍并提高CNS作用药的治疗效率NLC第二代脂质纳米载体,由于BB独有结构性能高涨药渗透量。
BB比起其他药载系统,它提供多项优势,包括易制造并推广到工业级,高药目标选择,高药加载,控制药释放,与多种药物相容性,非毒非刺激行为。
本审查突出介绍NLC开发面向脑生物主动性的最新进展,并特别参考其表面修改、配方方面面,药效行为和效果处理各种神经系统失常,如AD、PD、精神分裂症、脑癌、CNS感染(病毒和真菌)、多缓冲症、脑电解和脑膜疟疾这项工作详细描述NLC的作用和应用及其不同的编译技巧和相关限制。 具体强调汇编世界范围科学家和研究人员探索领域汇总和图形数据,处理NLC或非NLC神经失序文章还简要洞察脑定位的两种优选方法,包括跨BBB交付毒品和直接鼻对脑交付毒品以及当前特定神经系统失常的全球状态hrefs/www.scient.com/science/piet/nanotech/nano-lipid-carriers/Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent.指南通篇解释并插图Gattefosse指南并获取实用技巧成功编译 Compritolli 888ATO-点播GattefosseHrefs
BeitragCompritol® 888 ATO combines several advantages when used as a sustained release matrix agent.These will be explained and illustrated throughout this Guideline.
Download Gattefossé guidelines and get practical tips for successful formulation of sustain release tablets with Compritol® 888 ATO – click on the Picture
Der Beitrag Development of sustained release tablets with Compritol® 888 ATO – guidelines and practical tips erschien zuerst auf Pharma Excipients.
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques.然而,药物释放不稳定和缺乏基本理解是限制HMC工业生产应用的因素glysryl双接词库/correlation-service-code-api-mel-cote-clipses/
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques.药物释放不稳定和缺乏基本理解是HMC工业生产应用的限制因素。
微结构固态变换通过极分光显微镜学、DSC和火药X射线分片法研究N-acystene微信封与这些前接收器并储存在长期加速条件中3个月。
新封装微胶囊释放药受微结构、固态和HLB脂质涂层支配加速条件存储后释放剖面变换与某些脂质依赖时间结构变换相关。
glycryl二词存储后减慢释放药量的原因是脂晶体转换为xi形并密晶体结构。
Der Beitrag Correlation between the solid state of lipid coating and release profile of API from hot melt coated microcapsules erschien zuerst auf Pharma Excipients.
Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition.水分平衡确定水分状态(水输入和输出之差)。缺水或负水平衡受多种因素影响,无论是内部因素(即缺水感知)或外部因素(例如多药或慢性因素[.]
>Der Beitrag Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition.水分平衡确定水分状态(水输入和输出之差)。缺水或负水平衡受多种因素影响,无论是内部因素(即缺渴感知)或外部因素(例如聚用药或某些药的长期消费)。
Implication of Quantitative Selection of Each Excipient in Product Development Excipients' role in designing different dosage forms does not require any introduction.以上这些添加物与药理活性物质并发增加这些特性的主要目的是增加大数配方并传递所期望的[.]
Beitrag Excipients' role in designing different dosage forms does not require any introduction.以上这些添加物与药理活性物质并发增加这些特性的主要目的是增加大片配方并传递期望属性始发者像药物一样,需要验证和标准化下一章简单介绍不同用量表使用前接收者,包括固态用量表、液态用量表和半固态用量表计药先进配方领域的持续开发,我们还覆盖纳米化前接收者。 Implication of Quantitative Selection of Each Excipient in Product Development
Der Beitrag Current Developments in Excipient Science – Implication of Quantitative Selection of Each Excipient in Product Development erschien zuerst auf Pharma Excipients.
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours.稀疏选作孔化物代理物(液化或二基磷酸盐反水化)影响药物释放和稳定,3个月存储量为40摄氏度含晶矩阵片片片比含有二叉磷酸盐脱水片片片片放快 [.]
Der Beitrag Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours.稀疏选作孔化物代理物(液化或二基磷酸盐反水化)影响药物释放和稳定,3个月存储量为40摄氏度含晶矩阵片片比含二基钙磷酸3个月存储温度为40度后,含晶素片显示同一种药物释放量,而二基磷酸盐含水片的释放量则慢得多。同步光基X射线微计算断片用于评价矩阵片片分解期间和长期存储后微结构最终变化X光图像为药素的交互作用和前台面结构对药物发布超时的重要性提供了新洞察力。固滑前接收器可吸附于多基磷酸盐反水面纹理面,减少矩阵水渗透性并减慢药物释放These findings provide formulators with fundamental formulation considerations for the development of sustained-release matrix tablets using glyceryl dibehenate as release retarding agent. Download full article here: evolution-of-the-microstructure-of-sustainedrelease-matrix-tablets-during-dissolution-and-storage-3.pdf Der Beitrag Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage erschien zuerst auf Pharma Excipients.
13.2018年9月 2018年工作证明通过热熔拉通3D打印这种方法由三大简单技术操作组成,这些操作也可以在药店环境中实施。第一,除虫剂、药类和其他前接收者混入迫击炮并浸入塑胶机(即:[…]
Der Beitrag Personalized orodispersible films by hot melt ram extrusion 3D printing erschien zuerst auf Pharma Excipients.
13.2018年9月
这种方法由三大简单技术操作组成,这些操作也可以在药店环境中实施。第一,除虫剂、药类和其他前接收者混入迫击炮并浸入塑胶机(即:甘油)混合状填充器室加热ODF are individually printed on the packaging material foil and sealed without further manipulations.
The critical formulation attributes and process variables were investigated to define the processability space.具体地说,优化条件打印80/20w/w之比的恶性extrins/glycerine混合产生:加热温度:85摄氏度针表: 18G针包材料距离:0.6毫米最大打印速率:50mm/s填充角:120度最大药加载约40%,复合ODF顺从USP和Ph欧尔拆分时间规范paretamol离散模式与ODF获取的由合并溶化技术制作的相似组成模式重叠。
Der Beitrag Selecting Excipients for Liquid-Filled Hard Capsules erschien zuerst auf Pharma Excipients.
Excipient considerations
Capsule shell integrity.硬化胶囊含有13-16%水分液态聚乙烯甘醇等Hygroscopic运算器无法自用,填充胶囊水分半年不超过2%相对湿度65%和摄氏25度变化后, gelatin胶囊将保持完整性PEG 400和600还可能略微扭曲HPCC胶囊,因为PEG扩散导致壳墙膨胀PEG900不引起问题HPMC capsules (moisture content 3–8%) may be useful for moisture-sensitive and hygroscopic products and whenever capsules of vegetable source need to be used (2).
Jun 13, 2018
By Milind K.Biyani
Pharmaceutical Technology
Der Beitrag Selecting Excipients for Liquid-Filled Hard Capsules erschien zuerst auf Pharma Excipients.
20.2018年6月微孔是一个初级粒子系统制味,由生产过程定义的独特结构特征ibrofen脂微谱八DECANL和glycerin单粒子准备通过三种喷雾凝聚过程掩盖ibrofen不良品味,即空气冷却、水冷淡和柠檬酸解火[…]
Der Beitrag Optimization of taste-masking on ibuprofen microspheres with selected structure features erschien zuerst auf Pharma Excipients.
https://doi.org/10.1016/j.ajps.2018.05.003
Open Access funded by Shenyang Pharmaceutical University
Der Beitrag Optimization of taste-masking on ibuprofen microspheres with selected structure features erschien zuerst auf Pharma Excipients.