Background Nutraceuticals often referred as medicinally or nutritionally functional foods has drawn extensive attention in recent years because of their wide array of pharmacological activities.养分学消费一贯与预防慢性病相关联,如糖尿病、心脏病、癌症和神经退化性疾病。s/pharmaexbenses.com/news/self-emlipsation-formations-nutra/
Background
Nutraceuticals often referred as medicinally or nutritionally functional foods has drawn extensive attention in recent years because of their wide array of pharmacological activities.养分学消费一贯与预防慢性病相关联,如糖尿病、心脏病、癌症和神经退化性疾病。然而,这些养分学与治疗限制相关联,因为水溶性差、渗透性低、半衰期短最终导致人类生物利用率低Therefore, to overcome these issues self-emulsifying formulation approach which compose of oils, surfactants and co-solvents have been demonstrated to be an encouraging approach for augmenting the bioavailability and therapeutic efficacy of the nutraceuticals.
Highlights
Self-emulsifying formulations are promising approach for oral delivery of nutraceuticals.
Different kinds of self-emulsifying formulations are discussed.
Self-emulsifying formulations enhances permeation of loaded nutraceuticals through mucus barrier.
Pre-clinical studies demonstrate self-emulsifying formulations can augment therapeutic efficacy of nutraceuticals.
Scope and approach
In this review, we discuss various key constituents in self-emulsifying formulations and provide recent efforts to generate "solid self-emulsifying formulations" and "supersaturable self-emulsifying formulations" to overcome the problems related with liquid self-emulsifying formulations.自我仿真配方可影响养分吸收,增强生物可用性并继口服后增强养分疗效机制Finally, the potential of this formulation approach for nutraceuticals delivery is critically discussed.
Key findings
The self-emulsifying formulations have potential to augment the oral bioavailability and consequently therapeutic efficacy of nutraceuticals by various mechanisms such as reduction in intra-enterocyte metabolism by cytochrome P450 enzymes, inhibiting P-glycoprotein (P-gp) efflux transporter and bypass hepatic first-pass metabolism through lymphatic pathway.
Conclusion
Self-emulsifying formulations have emerged as preferable system for the formulation of nutraceuticals because of their ease of large-scale production, higher loading capacity, better dissolution behaviour of poorly water-soluble nutraceuticals, enhancement of oral bioavailability and their commercial potential.
Article information: Rakesh Kumar Dhritlahre, Ruchika, Yogendra Padwad, Ankit Saneja.自模配方增强养分疗效:从概念到诊所,食品科技趋势,卷1152021https://doi.org/10.1016/j.tifs.2021.06.046.
Der Beitrag Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to clinic erschien zuerst auf Pharma Excipients.
Context: Overcoming the intestinal mucosal barrier can be a challenge in drug delivery.负zeta潜力纳米化可有效渗透脉冲层,但有正zeta潜力者最好由细胞取用纳米仿真从负向正可实现良好渗透和高摄取目标:
DerBeitrag
Context: Overcoming the intestinal mucosal barrier can be a challenge in drug delivery.负zeta潜力纳米化可有效渗透脉冲层,但有正zeta潜力者最好由细胞取用负向偏向超强纳米小鼠:
/strong>Objective: 本研究旨在开发双作用Zeta-politi-aphteri 小鼠鼠标预聚积加阴极酸(SA),组成离子聚合物共聚二维度25比1与Eudragit RS100和Eudragit RL100之比空小鼠和装有复合物的小鼠在生理缓冲中单独稀释并检查小滴大小、多差指数、zeta潜力和细胞毒性小鼠综合体释放SA评价0.1m磷酸缓冲(pH6.8)含0.001%氟辛,从而立即减少荧光鼠标加载模型FDA并评价它们的粘膜行为和细胞吸收量。
Download the full research paper as pdf: Dual-Acting Zeta-Potential-Changing Micelles for Optimal Mucus Diffusion and Enhanced Cellular Uptake after Oral Delivery
Materials
Phenolic compounds (phenolics) have received great attention in the food, pharmaceutical and nutraceutical industries due to their health-promoting attributes.但它们的广泛使用有限,主要是因为它们在处理条件和/或肠胃交互作用下差分水和不稳定性,影响生物可用性/生物可用性hrefss/www.pharmaexsubjects.com/news/encapsation-phenclips-comps-2
Phenolic compounds (phenolics) have received great attention in the food, pharmaceutical and nutraceutical industries due to their health-promoting attributes.However, their extensive use is limited mainly due to their poor water dispersibility and instability under both processing conditions and/or gastrointestinal interactions, affecting their bioavailability/bioaccessibility.
Highlights
Phenolics have received great attention in the food, pharmaceutical and nutraceutical industries.
Their extensive use is limited mainly due to their poor water dispersibility and instability.
Nano/microemulsions have been widely used to encapsulate phenolics.
Stability, encapsulation efficiency, cytotoxicity, bioavailability and releasing rate are discussed.
Therefore, different nanocarriers have been widely used to encapsulate phenolics and overcome the aforementioned challenges.据我们所知,除多项研究外,迄今尚未发布关于微模和纳米模子封装的全面审查本研究因此试图审查Penlips加入MEs和NES.
并讨论开发系统的基本特征,如稳定性、封装效率、细胞毒性、生物可用率和释放率MEs和NEs都证明是封装保护Penlices的适当工具。Der Beitrag Encapsulation of phenolic compounds within nano/microemulsion systems: A review erschien zuerst auf Pharma Excipients.
Amphiphilic starches (sodium octenylsuccinate starches) are a well‐known emulsifier for various food and pharma applications.典型应用是嵌入维他命和其他微量素或直接或间接溶解药用物[1]流益星分子为获取仿真活动进行化学变换 [.]
Der Beitrag Amphiphilic starches (sodium octenylsuccinate starches) are a well‐known emulsifier for various food and pharma applications.典型应用是嵌入维他命和其他微量素或直接或间接溶解药用物[1]流益星体分子为获取仿真活动而修改化学特性,引入脂益异休克集团。 多例应用和微信化属性相关请求后,通过修改 starch主干定制商业产品司空见惯可实现,例如微信结构调制等关键应用属性,如水溶化和对疏水表面的吸附特性Literature reports, that the structure of the starch chain is of major importance of the emulsification capacity [2] and the emulsion structure. Materials: Several amphiphilic starches were used.They differ in the industrial way to design the starch backbone structure: Spray dried glucose syrup Glucidex® 29 (Roquette Frères, France), Medium chain triglycerides and sunflower oil were of laboratory / food quality. Article information: Olaf Häusler, G.舍尔市克罗格特G黎比汉市Roquette Frères 62080Lestrem法兰西Schär –BDS GmbH, Bättwil, Switzerland Der Beitrag Emulsification Speed of Amphiphilic Starches erschien zuerst auf Pharma Excipients.
Download the full poster as a PDF here
Abstract: Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy.产生各种副作用Sal极大限制应用上表生长因子受体家庭在大多数乳腺癌细胞中表现优异受体家庭GE11显示优异EGFR相似性[.]
Beitrag
Abstract:
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy.产生各种副作用Sal极大限制应用上表生长因子受体家庭在大多数乳腺癌细胞中表现优异受体家庭GE11显示优异EGFR相似性合成了一系列纳米粒子衍生物GE11编译PLGA/TPGS南极降水法用于准备Sal加载纳米粒子优化富集特征描述、目标定位效果和抗扰活动均检测到 invitro 和 ivo 约50%的乳腺癌病人最终引起肿瘤复发和/或转移,妨碍持久有效治疗。
Salistomiccin(Sal)切除药盐水溶性差和非大规模癌症细胞细胞毒性直接交付乳腺癌细胞将是一个宝贵的突破。标注纳米粒子开发成优秀药服系统,因为它们有希望性能和独特性,例如提高药不可应用性或药代特性。 此外,由于增强渗透性保留效果,静脉药可能在固态肿瘤网站积聚,从而产生临床增益并减少副作用。 生物可降解聚合物和生物兼容液类是纳米医学中常用的类别。液态是球状脂载体单层或多层并优于可行表面修改和长流时间ivo 编译液受不可控制释放毒品、不稳定性以及药装量不足的限制聚合滑动混合纳米粒子组合可以消除限制,但一些研究人员开发纳米粒子,将其作为强药提供系统处理癌症PLGA多语法co-glyclice酸特征是长效药物从多日释放到多周并简单配方多种方法,如表面仿真法、小说合成法和多词法In addition, PLGA shows advanced biocompatibility in vivo with a rigid structure. TPGS, D-α-Tocopheryl polyethylene glycol 1000 succinate, is a water-soluble derivative of natural vitamin E which can be used as solvent, stabilizer, and emulsifier for PLGA modification. These modifications can cause the size of PLGA nanoparticles be smaller and the drug encapsulation efficiency be higher. Moreover, both the PLGA and TPGS are approved by US food and drug administration (FDA) as safe pharmaceutical excipients. Some researchers have used PLGA/TPGS particles to deliver drugs for improving chemotherapy about multi-drug resistant breast cancer.
Epidermal growth factor receptor (EGFR) is greatly overexpressed on the surface of various human malignancies and regarding as a valuable target for cancer therapy include breast cancer. A screened small peptide GE11 by the phage display was demonstrated to have high affinity against EGFR significantly upregulated cancer cells. The affinity between GE11 and EGFR is significantly high (kd = 22 nM).GE11 has only 12 amino acids (YHWYGYTPQNVI) and is much smaller than the EFGR's ligand EGF. This small peptide targets only to one region of EGFR.s加载纳米粒子应用GE11定位peptide实现向乳腺癌细胞高效交付als-sal-GE11通过绑定反EGFRpitide与NP-Sal并用阳极反应进一步编译s-NPs-GE11对乳癌细胞的物理化学特征描述、目标效果和抗波活动在这次工作中得到了评价。
Der Beitrag GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells erschien zuerst auf Pharma Excipients.
Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate.精选每个组件以获取自模基Get TEFOSEQQQ63TefoseQQLis//pharmaexccepties.com/news/tefose-63-gatefosse/
Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate.The exact quantity of each component has been carefully selected to obtain a self-emulsifying base.
Tefose® 63 is a non-ionic oil-in-water emulsifier used in topical dosage forms.内含所有组件以易获取优异和均匀纹理传统仿真使用两种表面活性一带低HLB一带高HLB使用这些表面活性剂的不同比例进行数列模拟准备以确定模值稳定化之比(即:/p>
Names and synonyms:
USP NF Name: Mixture of Polyoxyl 6 Stearate Type I, Ethylene Glycol Stearates and Polyoxyl 32 Stearate Type I
EP Name: Mixture of Macrogol-6 stearate type I (pending), Ethylene glycol monopalmitostearate and Macrogol-3 stearate type I (pending)
UNII Code (FDA): 8LQC57C6B0 0324G66D0E 33GX5WQC0M
Preferred Substance Name (FDA): GLYCOL STEARATE PEG-6 STEARATE PEG-32 STEARATE
Handbook of Pharmaceutical Excipients: Polyoxylethylene stearates
Chemical description: Consists of a mixture of PEG-6 (MW 300) esters of stearic (C18) acid and ethylene glycol esters of palmitic (C16) and stearic (C18) acids and PEG-32 (MW 1500) esters of stearic (C18) acid
Key Characteristics:
Product form: Waxy solid
Melting range (°C): 46 – 53
HLB: 9.5
DOWNLOAD THE FULL 20 pages OVERVIEW PDF HERE
Main functionalities:
Versatile emulsifier for challenging topical formulations.广泛使用抗微生物学(Azole家庭)常用联模s/www.pharmaexccidents.com/product/labrafim-144-cs/传递感知和纹理属性安全使用由经批准的药剂产品优先使用推断。
TopicemOne-pot formulation process can facilitate manufacturing.
Der Beitrag Tefose® 63 – A nonionic oil-in-water emulsifier for topical formulations erschien zuerst auf Pharma Excipients.
The present work aimed to remove azithromycin (AZM) from contaminated aqueous system using a water/ethanol/transcutol/capryol-90 green nanoemulsion.药被确定为对水生生物和人体健康动植物产生有害影响的潜在药剂绿纳米模量定制并定性为热动稳定性、广度指数、Zeta潜力、粘性、[.]
Der Beitrag The present work aimed to remove azithromycin (AZM) from contaminated aqueous system using a water/ethanol/transcutol/capryol-90 green nanoemulsion.药被确定为对水生生物和人体健康动植物产生有害影响的潜在药剂绿纳米模量定制并定性为热动稳定性、广度大小、多差指数(PDI)、Zeta潜力、粘度、复用索引(RI)和形态评估使用传输电子显微镜(TEM)。
不存在接触时间对%RE结果的影响最大%RE值(96.8%)由ANE5从与ANE5接触20分钟后水溶液中获取ahrefs/www.pharmexbens.com/wp-content/uploads/2021/04/Remval-of-athromycin-frous-aques-bulk-solute-wea使用水/乙醇/转口醇/capryol-90绿纳米素清除水散解研究广场2021DOI:10.21203/rs3.rs-337792/v1.
Silymarin, a flavonolignan, derived from Silybum marianum, family Asteraceae has long been used as a hepatoprotective remedy.Silymarin有细胞保护活动 因为它有抗氧化特性 和自由提取活动药效学研究过去三十年显示Silymarin吸收不良和快速新陈代谢,特别是第二阶段代谢和最终口服差 [.]
DerBeitragSilymarin, a flavonolignan, derived from Silybum marianum, family Asteraceae has long been used as a hepatoprotective remedy.Silymarin有细胞保护活动 因为它有抗氧化特性 和自由提取活动药代学研究过去三十年显示Silymarin吸收力差,快速新陈代谢化学,特别是第二阶段新陈代谢和最终口服生物利用率差Quercetin是食用蔬菜和水果中的裂变物,它是一种强效抗氧化物并显示各种生物功能Querestin提高血液水平和药效量,因为它是P-Glycoprotein抑制器并抑制药物代谢酶。
bthSilymarin先进型配方如聚合纳米粒子可成功使用提高生物用量和Silymarin控件对肝细胞silymarinquestin自发仿真溶解法编译PNPsTPGS仿真并发配矩阵素材PLGA用于提高封装效率并改进纳米粒子药物发布剖面使用各种药的不同配方:聚合物比和体积和聚积药聚合比、体积和表面活性内容等配方参数效果得到评价。 表态学和纳米粒子大小通过扫描电子显微镜研究药包高效度和体外释放纳米粒子剖面使用紫外线分光测量测定纳米粒子结合本研究中两种药物制作 球状范围为100-200纳米事实显示TPGS是生产防水药纳米粒子并改进纳米粒子封装效率及药加载和药物释放剖面TPGS使用量对纳米粒子尺寸和形态有重大影响, 药加放剖面图. .ahrefss.com/wp-content/uploads/2021/04/Preparation-of-Silymarin-quercetin-loaded-Nanopartics.pdf塞提拉市Manoj Kumar和P文卡特山药学研究国际杂志84-94 2021第JPRI.66465条DOI:10.9734/JPRI/2021/V33i12358 DerBeitragApigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials.水溶性差和存储稳定性低限制了药区应用的可行性为解决此问题,本研究开发纳米聚合物/NEPS使用抗氧化聚合物/D-ffelly聚乙酸
Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials.水溶性差和存储稳定性低限制了药区应用的可行性研究用反毒聚合物、Apig化学稳定性显著提高,并因与BSFL油和AV油Nes合并而提高抗氧化能力,特别是单TPGSNes单端TPGSNES还展示最佳Apig皮肤沉积未来应用局部Apig投送NES-GelTheir rheological characteristics were dominated by the surfactant ratios of HL to TPGS.
Download the full article here or read it here
Article information: Chou, T.-H.!Nugroho D.S.长JY郑义秀梁城邓小J内温封装和特征化基于反氧化聚合二元交付。 ObjectiveApgenins 2021 , 13 1016https://doi.org/10.3390/polym1301016
Abstract: The vast majority of drugs are not designed or developed for pediatric and infant populations.Peptide药在过去几十年中变得日益重要,也不例外。近60+批药都配制注入方式, 一种对婴儿特别不友好的管治方式s/www.pharmaexsubjects.com/news/oral-pitide-petics-infants/
Abstract: The vast majority of drugs are not designed or developed for pediatric and infant populations.Peptide药在过去几十年中变得日益重要,也不例外。近60+批药都配制注入方式, 一种对婴儿特别不友好的管治方式三片药最近获批口服配方,在这次审查中,我们考虑当前口语配方的挑战和机遇,特别是为婴儿口语配方描述口服蛋白质传播策略 和婴儿生理学对这些策略的潜在作用微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微Together, these efforts underscore the feasibility of oral peptide delivery in infants and provide motivation to increase attention paid to this underserved area of drug delivery and formulation.
Download the full article here or read it here
Introduction
Historically, drugs are not designed for children or infants.这是因为儿童作为一个人口从药物开发角度提出了多项挑战举例说,在测试儿童药物时存在道德问题,而金融动机不足。此外,儿童在药用量表和生理学方面有独特的需求,这些需求与成人基本不同。
s-divider全小ss/p>见s/bs/pharmaex-infants/
"World Cancer Day every 4 February is the global uniting initiative led by the Union for International Cancer Control (UICC).通过提高世界范围的认识、改善教育并催化个人、集体和政府行动,他们正共同努力重新构思一个世界,在这个世界中,数以百万计可预防癌症死亡获救,人人享有救生癌症治疗和护理服务-不问
"World Cancer Day every 4 February is the global uniting initiative led by the Union for International Cancer Control (UICC).By raising worldwide awareness, improving education and catalysing personal, collective and government action, they're working together to reimagine a world where millions of preventable cancer deaths are saved and access to life-saving cancer treatment and care is equal for all – no matter who you are or where you live.
Created in 2000, World Cancer Day has grown into a positive movement for everyone, everywhere to unite under one voice to face one of our greatest challenges in history.
Each year, hundreds of activities and events take place around the world, gathering communities, organisations and individuals in schools, businesses, hospitals, marketplaces, parks, community halls, places of worship – in the streets and online – acting as a powerful reminder that we all have a role to play in reducing the global impact of cancer.
This year's World Cancer Day's theme, ‘I Am and I Will', is all about you and your commitment to act.UICC相信,通过我们的积极行动,我们可以一起实现到2030年将癌症和非传染病早死数减少三分之一的目标。”
BASF通过向制药业提供智能解决方案为可持续未来创造化学高素质行业引导产品使你能够开发出实现理想目标参数的药品。
BASF使用功能前端大组合解决口语语语句语句设计挑战。Download the brochure here and join BASF to inspire medicines for better lives.
Infographic: World Cancer Day Campaign Material by Union for International Cancer Control (UICC) is licensed under a Creative Commons Attribution-ShareALike 4.0 International License.
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Der Beitrag World Cancer Day 2021 – Functional Solutions for Oncology Pharmaceuticals erschien zuerst auf Pharma Excipients.
Desloratadine (DSL) is an anti-allergic agent but its efficacy is limited with its low dissolution rate and aqueous solubility results in restricted bioavailability.Kolliphor188(K188)和F127(P127)作为DSL溶解性改进剂的概率分析,DSL可用于编译面向nasals
Desloratadine (DSL) is an anti-allergic agent but its efficacy is limited with its low dissolution rate and aqueous solubility results in restricted bioavailability.当前研究检验使用kolliphor
Der Beitrag
Phospholipids are used in many types of formulations, such as fat emulsions, mixed micelles, suspensions, and liposomal preparations for any administration route [1-3].Posphlipid由极端头组和亲嘴尾组成并用作仿冒剂、润滑剂、溶解剂和前亲嘴类物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化药化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化物化磷素分子由甘卓骨架组成 [.]
Der Beltrag
Phospholipids are used in many types of formulations, such as fat emulsions, mixed micelles, suspensions, and liposomal preparations for any administration route [1-3].Posphlipid由极端头组和亲嘴尾组成hrefss/www.pharmaexbripss.com/emulser/'targets='blank'rel磷素分子由甘油骨架组成,在1和2级加脂肪酸,3级加磷酸,后者再加酒精最常见的磷素为磷化磷素(PC),而PC是Licthin的主要成分,见美国药典Posphlipids游戏,例如,Cellmbranes中的角色,有消化/代谢函数[4]lipseoprotein组件和乙酰胆碱源(PC)和(基本)脂肪酸和能量源[5]。
Figure 2.复元转换磷化物[7].
用于口服和皮肤调试的药产品中,主要使用大豆磷化物皮肤使用还应用氢化大豆磷化物单片产品中,自然磷素普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特普特Examples of parenteral liposome products for human use containing natural 7 phospholipids (in bold)." width="1068" height="608" srcset="//www.novoestroim.com/wp-content/uploads/2020/12/Table-1.-Examples-of-parenteral-liposome-products-for-human-use-containing-natural-7-phospholipids-in-bold..png 1068w, //www.novoestroim.com/wp-content/uploads/2020/12/Table-1.-Examples-of-parenteral-liposome-products-for-human-use-containing-natural-7-phospholipids-in-bold.-300x171.png 300w, //www.novoestroim.com/wp-content/uploads/2020/12/Table-1.-Examples-of-parenteral-liposome-products-for-human-use-containing-natural-7-phospholipids-in-bold.-1024x583.png 1024w, //www.novoestroim.com/wp-content/uploads/2020/12/Table-1.-Examples-of-parenteral-liposome-products-for-human-use-containing-natural-7-phospholipids-in-bold.-150x85.png 150w, //www.novoestroim.com/wp-content/uploads/2020/12/Table-1.-Examples-of-parenteral-liposome-products-for-human-use-containing-natural-7-phospholipids-in-bold.-768x437.png 768w, //www.novoestroim.com/wp-content/uploads/2020/12/Table-1.-Examples-of-parenteral-liposome-products-for-human-use-containing-natural-7-phospholipids-in-bold.-600x342.png 600w" sizes="(max-width: 1068px) 100vw, 1068px" />Table 1.嵌入式滑动产品实例中含有自然磷化物(用粗体表示)。
Egg磷化物Intralipid®) [10].油溶性药用物,如二联苯基和二联苯基[11、12]. p>pienter混合小鼠配方,由豆类磷化素和合氯酸盐组成,或适合溶解维他命K或豆类磷化物作为主动药用成分处理肝错乱[13]这些产品强调安全静脉注射大豆lecithin[14]. 自然磷素摘自牛或牛排提取处理Restistrials综合症inbrijaQQ由12dalimityl-sn-glyce-3-phosholine组成。 Natural磷化物为监管部门所熟知并在许多药典中描述[16]关于磷素毒性问题,世界卫生组织、美国林业局和欧盟不限制异硫素口服添加剂[17-19]安全静脉注射大豆和鸡蛋磷化物记录充分[20]. 安全管理路线嵌入式应用使用蛋类、大豆和氢化大豆磷化物,合成磷化物除外口服大豆磷化物占上风,而皮肤局部化大豆磷化物则受欢迎吸入产物中含有自然磷素提取物和合成磷素关于自然和合成磷化物用法的更多资料参考van Hoogevest,P andWendel,A:“使用22自然和合成磷化物作为药前接受者”(1616). /ahrefs='https/www.pharmaexbiders.com/wp-content/uploads/20/12/the-us-phoplips/s-frucetices-exferr.pdf'Peter van Hoogevest,Phospholipid Research Center Heidelberg, Germany.
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