解析器-Pharma前接收器

deximathone-loaddNano结构Lipid载体处理干眼病

汤姆 — Frii,2021年6月25日7:0001+00

srcs/www.pharmaexsubjects.com/wp-content/uploads/2021/06/Deximated-Nasted-Listed-Carriers-f-Treatment-Dry-Eye-served.jpg类sAll treated corneas used 50 µL of either a 0.1% (w/v) coumarin-6 solution or the same volume of an NLC solution loaded with 0.1% (w/v) coumarin-6." loading="lazy" srcset="//www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-scaled.jpg 2560w, //www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-300x234.jpg 300w, //www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-1024x800.jpg 1024w, //www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-150x117.jpg 150w, //www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-768x600.jpg 768w, //www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-1536x1200.jpg 1536w, //www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-2048x1599.jpg 2048w, //www.novoestroim.com/wp-content/uploads/2021/06/Dexamethasone-Loaded-Nanostructured-Lipid-Carriers-for-the-Treatment-of-Dry-Eye-Disease-600x469.jpg 600w" sizes="(max-width: 2560px) 100vw, 2560px" />

Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction.症状包括干燥性、刺激性、不适和视觉干扰,标准处理包括润滑油和局部类固醇使用二次炎症在开发传播这一虚弱条件中起着突出作用。

解决此点,我们已经调查创新药物提供系统实验规模开发使用 dexethasone/emoji/13.0.172/2122.png' altss/www.pharmaexccidents.com/product/labrafac-lipoptile-wl-1349/最大高度:1em;"/ > 亲脂载量/a快速筛选实验室规模预编程后,所选配方以实验规模编译,粒度为19.51+++0.5Nm,封装效率99.6+++0.5%,PDI0.08和4°C扩展稳定性6个月观察发现,这种潜在的眼科配方具有高可耐性并内化能力,在ex vivoporcine角膜研究中展示相似行为,建议奥氏表面适当分布。

p>serve,ELISA用于研究实验级配方对各种炎症生物标志的影响最成功的解甲松装入NLC显示单方三叉松TNF-A生产5倍下降,MMP-9和IL-6相仿结果易编译性、可扩缩性、性能和生物标志分析显示,NLC配方可成为DED专题处理的可行选项。

ahref='https//www.pharmaexbiders.com/wp-content/uploadss/2021/06/Dexicathone-Loaded-Nanostrationd-Lipid-Carriers-s-the-Treatment-Dry-Eye-Disaces.pdf'丹达穆迪MRani S.贝海盖尔E贝哈尔G肯特D欧里利NJ欧多诺万市麦克劳林市菲茨亨里市deximetasoni-loadnationlipid载体处理干眼疾病。药理 2021 , 13 905https://doi.org/10.3390/pharmaceutics13060905

Der Beitrag Dexamethasone-Loaded Nanostructured Lipid Carriers for the Treatment of Dry Eye Disease erschien zuerst auf Pharma Excipients.

电影编程系统送药

Philippe语言 — 2021年6月24日05:30:19+00

Film-forming formulations represent a novel form of sustained release dermatic products.用于皮肤液化或半固化编程通过皮肤挥发溶剂蒸发,配方内含聚合物组成固膜各种胶片配方测试水阻和压强并比对传统半固化配方渗透渗透研究显示半转基因治疗系统有潜在实用性可替代补丁系统以切题方式管理各种药物并持续发布特征。

下载整篇文章: >Film-Forming系统提供脱热药 /Lunter DJFilm-Forming Systems for Dermal Drug Delivery. Pharmaceutics 2021, 13, 932.https://doi.org/10.3390/pharmaceutics13070932

Polymers for use in film-forming formulations

Polymer	Properties
Carbopol (polyacrylat)	water-soluble, pH sensitive
Chitosan (Poly-D-Glucosamin)	water-soluble at pH < 7
Crosslinked polymer layer XPL	adhesive, elastic
Dermacryl 79 (Carboxylates Acrylpolymer)	water-insoluble

Ethylcellulose	non-toxic, not irritating, anti-allergic
Eudragit NE (ethylacrylate methylmethacrylate copolymer)	water-insoluble, transparent, elastic, adhesive
Eudragit RL-100 (polymethacrylate polymere)	water-insoluble, transparent, elastic, adhesive
Eudragit RS-100 (polymethacrylate polymere)	water-insoluble, transparent, elastic, adhesive
Eudragit L30D-55 (methacrylate-ethylacrylate-copolymer)	water dispersible at pH 2–3
Hydroxypropyl-beta-cyclodextrin	water-insoluble, increases bioavailability
Hydroxypropylmethylcellulose (HPMC)	water-soluble, non-ionic
KIucel (Hydroxypropyl cellulose)	water-soluble, non-ionic
Macrogol	water-soluble
Methyl cellulose	water-soluble
Poloxamer (polyethylenepolypropylene glycol)	thermoreversible
Plastoid (Butyl methacrylate-methylmethacrylate copolymer)	water-insoluble
Polydimethylsiloxane (PDMS)	water-insoluble, non-toxic
Polyvinyl alcohol (PVA)	water-soluble, adhesive, non-toxic
Polyvinyl pyrrolidine (PVP)	water-soluble, adhesive, increase bioavailability
Quaternary polymethacrylat (QPM)	water-insoluble
Sepineo P600 (acrylamide/sodium acryloldimethyltaurate)	water-insoluble
Silicone	water-soluble, non-occlusive

Conclusions and Further Prospects

According to previous research findings, film-forming systems have proven to be suitable for use as a delivery form due to their high substantivity and cosmetic attractiveness.药能从系统渗透到皮肤上,使皮肤和转基因药物应用成为可能配方还起仓库作用,持续释放薄膜喷雾在伤口护理领域已经建立并被病人广泛接受,而薄膜编程系统仍然是治疗疾病的例外。成片系统尚未能建立成治标法以对抗补丁等其他转基因系统光素LamisilOnce喷雾等胶片制作法研究慢性皮肤疾病时,尚没有配方供病人使用,既非可口可乐形式日常治疗,非可口可乐配方开发慢性炎性皮肤病和点染配方法可在未来更大力地实施。 Film成型法直接喷射皮肤产生二次皮肤感知,不同于补丁分分系统精确应用和 dosing使用补丁更容易实现,这些补丁也能保护处理过的皮肤面积并显示提高物理稳定性胶片仿真还含有亲脂相,因此也可用于干皮肤区由于其半固态性能,Gels的优势在于更容易和精确应用所有系统都完全适合个性化理疗半固态和液态配方可按单个集成制片,电影可逐个打印。在此背景中,胶片仿冒器可能比胶片造模系统更重要,因为胶片喷雾迄今为止主要建立起来,更容易应用。这些配方可用于慢性发炎皮肤病,除弱排出活性成分和高基分量外,对皮肤特性有正效果。skin-form-form-systems-dermal-form-servation/

论题Nioemulgel皮肤癌治疗:技术证明

Philippe语言 — 2021年6月23日wed:2.30:27+00

The present study is a mechanistic validation of ‘proof-of-technology' for the effective topical delivery of chrysin nanoemulgel for localized, efficient treatment of melanoma-affected skin.

Background: Currently available treatments for skin cancer are inefficient due to systemic side effects and poor transcutaneous permeation, thereby presenting a formidable challenge for the development of novel nanocarriers.

Methods: We opted for a novel approach and formulated a nanocomplex system composed of hydrophobic chrysin dissolved in a lipid mix, which was further nanoemulsified in Pluronic^® F-127 gel to enhance physicochemical and biopharmaceutic characteristics.Chrysin从情花中提取的fraftone展示潜在的反癌症活动但由于可溶性差,应用性有限伪相位图构建以辨识最佳自失效区, 方法有各种构件, >matileset方法 Chrysin从印度Sigma-Aldrich公司购买Acrysol ^{K-140和Acrysol ^{K-150Capmul ^{/sup>MCM(gryryrylate/capate)和Captexsup>sup>/sup>355}}}Caproyl^® 90 (propylene glycol monocaprylate), Labrafac^® CC (caprylic capric triglyceride), and Labrasol^® (caprylocaproyl macrogol-8 glycerides) were gifted by Gattefosse India Pvt., Ltd.蒙拜市Tween ^{20和Tween ^{80从Molychem购买(印度蒙拜市)。Cremophor^® EL, Cremophor^® RH 40, and Pluronic^®F127 were received as gift samples from BASF (Mumbai, India).聚乙烯甘醇400和丙烯甘醇从LobaChemie有限公司购买蒙拜市96%span类表示'html-itic'v/span>/span类表示'html-itic'v/span所有这些化学物都具有分析等级,使用时不作任何进一步的净化3-(4,5-二亚卓-2-yl)-2,5-二联四联苯四联苯溴化二苯mexips.com/topial-noulgel-skin-cer/}}

ketorac加注微模法开发使用D最优实验法

Markuskobel — Sun,06Jun202102:30:14+00

Aim of the present study was to evaluate the potential of microemulsions for the transdermal delivery of ketorolac tromethamine.伪代相图3D最优混合设计用于开发期望属性微模17试运行使用三种变量执行,石油百分数、水和表面活性与共冲比优化比,而所调查的响应为百分数传输和Globule尺寸微浮系统由eclyptus油类组成,Metes Salicylate,

See the article here

Tripti Shukla, Sharad Prakash Pandey, Piyuh Khare, Neeraj Upmanyu,
Development of ketorolac tromethamine loaded microemulsion for topical delivery using D-optimal experimental approach: Characterization and evaluation of analgesic and anti-inflammatory efficacy,
Journal of Drug Delivery Science and Technology, 2021, 102632,
https://doi.org/10.1016/j.jddst.2021.102632.

Der Beitrag Development of ketorolac tromethamine loaded microemulsion for topical delivery using D-optimal experimental approach: Characterization and evaluation of analgesic and anti-inflammatory efficacy erschien zuerst auf Pharma Excipients.

蒙塔诺克80PI和蒙塔诺克20PPI目前在中国市场达标

汤姆 — Thu,2021年5月20日09:30:11+00

Montanox 80 PPI and Montanox20PI ,Sepci开发并制作的成分,符合当前中药典并自2021年5月起在中国营销最大值:1em;sorbates运算解析器或稳定器范围最大值:1em;'/>可注入范围用于溶解药用和/或生物活性成份并编译油水模mages/core/empji/13.0.1/72x72/2122.png最大高度为1em;'/>20PISepci向全世界客户提供最高安全可靠性。Sepci市场管理员CéliaHerou表示 : “ 通过满足中国药店的要求,我们正在满足全球药市场增加的监管要求和需求。Seppic's strength is that we control all stages of product manufacturing, following GMP."

Download the full press release here!

More about Seppic

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All Excipient Production Sites With GMP Certification

Der Beitrag Seppic injectable polysorbates Montanox™ 80 PPI and Montanox™ 20 PPI are now compliant in the Chinese market erschien zuerst auf Pharma Excipients.

增强API溶解性稳定高药载荷-分片MXP

汤姆 — 图族2021年4月29日2.3012+00

Poor solubility of APIs is a critical challenge in drug development.一种配方技术提高溶性并进而提高药物生物可用性,即热熔化放大使用这种技术,API分解成聚合矩阵组成不定固散进程可应用范围广易解性API,使之适合各种固态剂量配方。

p>ParteckQMXP是新多维英酒精前接收器,专门设计用于HME提高溶性并允许多种API稳定高药载量This animation provides an overview of the features and benefits Parteck® MXP offers in the HME process.

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Benefits of Parteck® MXP:

Enhanced solubility of APIs
Stable, high drug load under various conditions
High thermo-stability (above 200 °C) and a Broad API Application Range
Variety of final oral dosage forms with immediate or sustained release kinetics using the same extrudates
Ease of use thanks to optimized physical properties

GET PARTECK® MXP HERE

溶解物、仿冒物、共生物和复杂物对Ex Vive鼠标局部易容性的影响

汤姆 — 2021年4月21日wed9:3011+00

A great need exists to develop tocolytic and uterotonic drugs that combat poor, labor-related maternal and fetal outcomes.一种广泛使用的方法评估新化合物的图解和子宫效果,即实测器官槽易容性解析水溶性复合物很难使用生理缓冲机槽解析法测试。

共通方法解决溶性问题包括溶解变换法、溶解变换法、悬浮法或复合法使用法和仿化法然而,这些药送或配方选择会影响组织功能因此,本项研究的目标是评价常用溶剂、表面活性剂、溶解剂和仿真体在器官浴检测中适当溶解复合物而不影响鼠标粒度缩合性的能力extiacemide、egyacateatate和isopra水底浸泡无毒统计效果超出控制范围(水),而药浸泡效果与自由溶解药相同。

/ahrefss/www.pharmaexbits.com/wp-cont/uploads/2021/04/Effects-softs-Solvents-Emulsions-Cosolips-Relevations-on-ExVivo-Mouse-Myome-Sci. (2021).https://doi.org/10.1007/s43032-021-00576-5

Der Beitrag Effects of Solvents, Emulsions, Cosolvents, and Complexions on Ex Vivo Mouse Myometrial Contractility erschien zuerst auf Pharma Excipients.

硫化环流驱动抗病毒复元:电阻和液化配方特征

汤姆 — 元2021年4月19日9:30+00

VekluryGileScience Inc.含有抗病毒药RemdesivirHere, for the first time, we describe details of the non-covalent, host-guest type interaction between REM and the solubilizing excipient, sulfobutylether-beta-cyclodextrin (SBECD) that results in significant solubility enhancement.

Highlights

Sulfobutylether-beta cyclodextrin-enabled remdesivir formulation is a molecularly disperse, amorphous, instantly soluble system.

The host-guest type interaction is based on the co-existence of inclusion phenomenon and electrostatic interactions as proved by NMR.

Solubilization power of SBECD for REM is both SBECD concentration- and pH-dependent.

The REM-SBECD composition has high excess of SBECD over remdesivir: 3 % REM over 97 % SBECD by weight.

Reconstitution properties of electrospun nanofiber form of the REM-SBECD complex surpass that of the freeze-dried forms.

Therapeutic use of antiviral REM (Verklury )由二联二联二联二通

溶解碳水合物的使用使REM水溶性提高300倍,并增强药物分解率以准备稳定的注入法治疗2D ROESY NMR spectroscopy provided information on the nature of REM–excipient interaction and indicated the presence of inclusion phenomenon and the electrostatic attraction between anionic SBECD and nitrogen-containing REM in aqueous solution.

Download the full article here or read it here

Article information: Lajos Szente, István Puskás, Tamás Sohajda, Erzsébet Varga, Panna Vass, Zsombor Kristóf Nagy, Attila Farkas, Bianka Várnai, Szabolcs Béni, Eszter Hazai.碳水化合物聚合物,卷2642021https://doi.org/10.1016/j.carbpol.2021.118011.

Der Beitrag Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations erschien zuerst auf Pharma Excipients.

热活性N-2-Hycroyprylmethacrylame

汤姆 — 网点720219:3006+00

Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles.聚合物 N/em>-(3-minoprayld盐酸使用疏水嵌入器组编译成原生amine组本研究所选择的分解群数为palitiyl、dansyl和chosterylmities.

生成集成水解封并解放模型药(如propofol、griseofulvin和pridniso数据显示HPMA基础配方能够加载模型药分子HPMA-co-(APMA-Dansyl2%)展示最大药封装能力PEG内部聚合结构集成.

类似地,profol显示70%自聚合物聚合24小时后解放,而解放前解放率只有30%HMPA光量运货/释放系统的潜在作用深入了解。
Lamprou,Anthony Curtis,ClareHoskins,药理学杂志,2021年https://doi.org/10.1016/j.ijpharm.2021.120570.

Der Beitrag Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation erschien zuerst auf Pharma Excipients.

galenIQTM-问专家Webinar录制

汤姆 — 2021年4月6日05:30:50+00

We had a webinar with the experts from BENEO to find out more on galenIQs.w.org/images/core/emoji/13.01.072x722122.png'alt=TM类最大高度为1em;'/>可解析填充器和绑定器,可用于应对当前许多趋势和挑战galenIQ系植物前接收器,特征是易用性并可应用性广度固态和液态形式,如平板机、沙粒机、树枝和糖浆CGMP按IPEC-PQG对药业前接受者的要求制造并符合当前PHEur., BP, USP-NF and JP monographs for Isomalt.

galenIQ^TM is known for its outstanding taste properties and makes medicine taste great.

WATCH the Webinar Recording FOR FREE

Have a look at a selection of the webinar Q+A here:

Q1: "What is the maximum daily intake of galenIQ?"

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Q2: "Which disintegrant is recommended for fast release tablets based on galenIQ?"

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Q3: "Can we substitute mannitol in tablets with galenIQ without negative impact on the stability?"

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Der Beitrag galenIQ™ – Ask the expert!webinar录制 erschienzufta

Silymarin-questin加载纳米粒子编译

汤姆 — 周五2021年4月5日 09:30:35+00

Silymarin, a flavonolignan, derived from Silybum marianum, family Asteraceae has long been used as a hepatoprotective remedy.Silymarin有细胞保护活动因为它有抗氧化特性和自由提取活动药代学研究过去三十年显示Silymarin吸收力差,快速新陈代谢化学,特别是第二阶段新陈代谢和最终口服生物利用率差Quercetin是食用蔬菜和水果中的裂变物,它是一种强效抗氧化物并显示各种生物功能Querestin提高血液水平和药效量,因为它是P-Glycoprotein抑制器并抑制药物代谢酶。
bthSilymarin先进型配方如聚合纳米粒子可成功使用提高生物用量和Silymarin控件对肝细胞silymarinquestin自发仿真溶解法编译PNPs使用可生物分解聚合物PLGA D-alpha-tocopheryl聚类TPGS仿真并发配矩阵素材PLGA用于提高封装效率并改进纳米粒子药物发布剖面使用各种药的不同配方:聚合物比和体积和聚积药聚合比、体积和表面活性内容等配方参数效果得到评价。
表态学和纳米粒子大小通过扫描电子显微镜研究药包高效度和体外释放纳米粒子剖面使用紫外线分光测量测定纳米粒子结合本研究中两种药物制作球状范围为100-200纳米事实显示TPGS是生产防水药纳米粒子并改进纳米粒子封装效率及药加载和药物释放剖面TPGS使用量对纳米粒子尺寸和形态有重大影响, 药加放剖面图.
.ahrefss.com/wp-content/uploads/2021/04/Preparation-of-Silymarin-quercetin-loaded-Nanopartics.pdf塞提拉市Manoj Kumar和P文卡特山药学研究国际杂志84-94 2021第JPRI.66465条DOI:10.9734/JPRI/2021/V33i12358
DerBeitrag

婴儿口服pitide治疗法:挑战与机遇

汤姆 — 周三2021年4月12:30:25+00

Abstract: The vast majority of drugs are not designed or developed for pediatric and infant populations.Peptide药在过去几十年中变得日益重要,也不例外。近60+批药都配制注入方式, 一种对婴儿特别不友好的管治方式三片药最近获批口服配方,在这次审查中,我们考虑当前口语配方的挑战和机遇,特别是为婴儿口语配方描述口服蛋白质传播策略和婴儿生理学对这些策略的潜在作用微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微信微Together, these efforts underscore the feasibility of oral peptide delivery in infants and provide motivation to increase attention paid to this underserved area of drug delivery and formulation.

Download the full article here or read it here

Introduction

Historically, drugs are not designed for children or infants.这是因为儿童作为一个人口从药物开发角度提出了多项挑战举例说,在测试儿童药物时存在道德问题,而金融动机不足。此外,儿童在药用量表和生理学方面有独特的需求,这些需求与成人基本不同。
这些药物开发挑战产生两大问题首先是许多婴儿和童年条件根本无药可用,包括死环球炎、童年间肺病和自休多细胞肾病[1、[2]、[3]反过来,这可能说明临床试验中小儿病人注册率比成人低10倍[4]问题二是当适当药确实存在时,此类使用可能改变核准剂量、时间段、剂量表和/或管理路线不幸地,离标签处方导致负药响应量倍增(例如:呕吐和查获)许可用药[5]、[6]并伴生病人死亡率上升,因为成人与儿童之间的生理差异理解度低[7]此外,剂量调整通常通过基于权或体表面积的教育猜想法实现。因此,显然需要优化药配方专为小儿群设计。
口语配方很容易在保健环境外管理,理想长期使用,并很容易在出现不良反应时停止使用此外,平板药和其他固态用量表便于活性药素保值长,而无菌和专用药用量表则[9]小儿病人尤其从口服药中受益,因为儿童往往比成人更容易受注入困扰。儿童有时难以吞下固剂量表,但多片抗生素和非静态抗炎药已配制成液以方便小儿病人使用[10]药剂师往往瞬时溶解、稀释或复发配方,以不同浓度或不同介质为成人制作婴儿用药[11]、[12]这是一项重大安全关注问题,并由于复杂改变成人配方而没有明确指导或标准[13].
Peptide和蛋白质药是药市场唯一和关键部分,3种新pitide药在2019-2020年获得批准,另外150种主动开发[14],[15]petide药对小分子药有一些关键长处,包括更高特性和更精密药理作用机制,可用于治疗复杂疾病成功pitide药包括治疗糖尿病的胰岛素和治疗生长失常的人类生长激素浸化药因物理化学特征而难以编译和交付,尤其是口服路由。因为这些挑战延缓了pitide药的研发和市场认可,也阻扰了这些药在小儿群中的应用。
婴儿定义为1至24个月[16]新产儿交付药物可提供替代审查,新产子小于一个月[11]上半期审查中,我们讨论小便药管道的现状, 以及口服配药的挑战和解决方案第二部分审查侧重于独特的婴儿和成人胃生理问题,这带来了独特的药物交付挑战,突出了该领域知识的重大空白。上传传统药研发方法对婴儿来说也取得了令人鼓舞的进展.
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开发多L解析多功能渗透自化药服系统,以改进coproxacin对细胞内Salmonellabashi的溶解和定向交付

汤姆 — 2021年3月31日12:30:06+00

Salmonella typhi infections are difficult to treat due to poor penetration of current antibiotic ciprofloxacin (CIP)modalities into the intracellular compartments of macrophages owing to poor solubilization and oral bioavailability.低渗透分解导致细胞内病原体开发多药阻抗和抗生物膜编组在此,我们开发新策略设计开发CIP自化药服系统,以高特性和选择性面向细胞内Salmonella webhi Tween 80, and PEG 200 were selected as oil, surfactant and co-surfactant based on solubilizing capacity and pseudo ternary diagram emulsification capability.

Highlights

Muco-penetrating amphiphilic conjugate for the first time incorporated into SEDDS.

Multi-functionalized SEDDS shows non-toxic behavior on Macrophages RAW 264.7.

SEDDS are involved in intracellular targeted killing of S.prashi. ssEDDS克服 ssEDDS通过绕过非专用交付药来提高CIP溶解度大有希望。

/ddslist描述> >>sEDDSPLL-M-PTHA-F127开发成复用双渗透目标反生物实体,用于细胞内对salmonella webhi Invitro PLL-M-PTHA-F127 SEDDS显示极强杀法对salmonella wekhi -SEDDSTabish、Abbas Ali Naseem、Muhammad Rauful Hassan、Irshad Hussein、ShahzadShaikh Hussein、Gul Shahnaz分子液学杂志2021年https://doi.org/10.1016/j.molliq.20115972.
Der Beitrag

开发用Box-Behnken设计提高分解和口服生物可用性

Markuskobel — 太阳2021年2月21日

Purpose: To enhance the oral bioavailability of revaprazan (RVP), a novel solid, supersaturable micelle (SSuM) was developed.

Methods: Surfactants and solid carriers were screened based on a solubility and a flowability test, respectively.超饱和物剂,包括Poloxamer407SSUM优化使用box-Behnken设计三大独立变量,包括Gerucre44/14 :BrijL4G44/BL4X1和FloritePS-10X2) and Vivapur 105 (VP105!X3三大响应变量i解析效率为30分钟Y1解析增强容量Y2和Carr索引Y3固态属性评价并进行分解测试RVP、Revanex和Susum口服大鼠20mg/kgP407超饱和效果极佳FLO和VP105选择为固态载波,临界固化比(g/mL)分别为0.30和0.91优化值X1(-0.41)、X2(0.31)和X3(-0.78)、RVP(200 mg)-含SSUM组成G44(253.8mg)、BL4(106.2mg)、FLO(99.3mg)、VP105(199.8mg)和P407mgRVP优化SSUM状态不定,SSUM在水相中形成纳米散射,约71.7%分解2小时The optimized SSuM improved the relative bioavailability of RVP in rats by approximately 478%, 276%, and 161% compared to raw RVP, Revanex®, and solid micelle, respectively.

Conclusion: The optimized SSuM has great potential for the development of solidified
formulations of poorly water-soluble drugs with improved oral absorption.

Download the full research paper here: Development-of-a-solid-supersaturable-micelle-of-revaprazan

Materials
RVP powder (purity >99%) and Revanex® tablets containing 200 mg RVP were supplied by Yuhan (Seoul, Korea).
Aerosil® 200 was supplied by Evonik Degussa GmbH (Frankfurt am Main, Germany).a hrefss/www.pharmaex接受者.com/product/avicel-ph-101Louis,MO,USA)FloritePS-10Calcium硅酸盐公司从Tomita药厂Ltd.东岛市Gelucire 44/14 (G44), Labrafil® M 1944 CS, Labrasol®, and Lauroglycol® 90 were gifted by Gattefossé (Saint Priest, France).Kolliphor® EL, Kolliphor® RH40, Kolliphor® RH60, Kollidon K30, Kollidon K90, Poloxamer (P)188, and P407 were obtained from BASF (Ludwigshafen, Germany).低替代液压B1由Shin-Etsu化工有限公司提供京京市Neusilin® US2 (magnesium aluminometasilicate) was supplied by Fuji Chemical Industry Company (Toyama, Japan).Sylysia-350(微软西里卡)由Fuji Silysia化工有限公司提供爱知市Vivapur (VP)12 and VP105 were supplied by JRS Pharma (Rosenberg, Germany)

Keywords: revaprazan, supersaturation, solid micelle, Box-Behnken design, dissolution,
oral bioavailability

Yoon Tae Goo, Cheol-Ki Sa , Ji Yeh Choi, Min Song Kim, Chang Hyun Kim, Hyeon Kyun Kim, Young Wook Choi
International Journal of Nanomedicine, 2021:16 1245–1259

Der Beitrag Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral Bioavailability Using Box-Behnken Design erschien zuerst auf Pharma Excipients.

世界癌症日2021-肿瘤药房功能解决方案

汤姆 — Thu,042021年2月1日:22+00

"World Cancer Day every 4 February is the global uniting initiative led by the Union for International Cancer Control (UICC).By raising worldwide awareness, improving education and catalysing personal, collective and government action, they're working together to reimagine a world where millions of preventable cancer deaths are saved and access to life-saving cancer treatment and care is equal for all – no matter who you are or where you live.

Created in 2000, World Cancer Day has grown into a positive movement for everyone, everywhere to unite under one voice to face one of our greatest challenges in history.

Each year, hundreds of activities and events take place around the world, gathering communities, organisations and individuals in schools, businesses, hospitals, marketplaces, parks, community halls, places of worship – in the streets and online – acting as a powerful reminder that we all have a role to play in reducing the global impact of cancer.

This year's World Cancer Day's theme, ‘I Am and I Will', is all about you and your commitment to act.UICC相信,通过我们的积极行动,我们可以一起实现到2030年将癌症和非传染病早死数减少三分之一的目标。”More onUICC 估计到2040年全球新病例数将增至2 750万例对许多人来说,癌症将意味着多年治疗和后续约见,付出巨大的体力、情感和财政代价。BASF药理解决方案提供素材促进高质量处理和护理相信启发性药物改善生活,因为良好的健康对繁荣、增长和实现生活至关重要。
共同建设可持续未来
BASF通过向制药业提供智能解决方案为可持续未来创造化学高素质行业引导产品使你能够开发出实现理想目标参数的药品。
BASF使用功能前端大组合解决口语语语句语句设计挑战。

Download the brochure here and join BASF to inspire medicines for better lives.

Infographic: World Cancer Day Campaign Material by Union for International Cancer Control (UICC) is licensed under a Creative Commons Attribution-ShareALike 4.0 International License.

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Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer

Challenges and opportunities in the delivery of cancer therapeutics: update on recent progress

Nanocarriers based on vitamin E-TPGS: Design principle and molecular insights into improving the efficacy of anticancer drugs

Der Beitrag World Cancer Day 2021 – Functional Solutions for Oncology Pharmaceuticals erschien zuerst auf Pharma Excipients.