设计用于热融化涂层的最佳配方

Hot-melt涂层（HMC）作为一项无溶剂技术，可以更快地授予更快的经济涂料过程，从而降低了在此过程中溶解该药物的风险。此外，可以修改传统涂料设备以实现HMC流程。尽管该过程具有不可取的优势和可行性，但HMC并不是制药行业众所周知的，其就业仍然有限。阻碍该技术广泛应用的主要方面是需要替代传统聚合物的材料涂层s.

The current work reviews the published HMC formulations and describes the properties that have led to their selection. As these materials are mainly solid lipid excipients, attention should be paid to their crystallization and solid state behavior, and their impact on the performance of coated drug products, particularly on the stable drug release profile.

Although different drug release profiles can be easily tailored, much development work is needed to respond to the unmet requirements of a stable formulation. Ensuring stable solid-state behavior and providing a mechanistic understanding of the macroscopic properties are essential steps towards fulfilling these requirements and establishing of HMC as advanced coating technology for manufacturing of pharmaceutical products.

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设计用于热融化涂层的最佳配方
Author: Diogo Gomes Lopes,Sharareh Salar-Behzadi,Andreas Zimmer
Publication: International Journal of Pharmaceutics
Publisher: Elsevier
Date: 30 November 2017