聚合系统用于药物输送的碳水化合物：从结构到应用

Abstract

Carbohydrates, one of the most important compounds in living organisms, perform numerous roles, including those associated with the extracellular matrix, energy-related compounds, and information. Of these, polymeric carbohydrates are a class of substance with a long history in drug delivery that have attracted more attention in recent years. Because polymeric carbohydrates have the advantages of nontoxicity, biocompatibility, and biodegradability, they can be used in drug targeting, sustained drug release, immune antigens and adjuvants. In this review, various carbohydrate-based or carbohydrate-modified drug delivery systems and their applications in disease therapy have been surveyed. Specifically, this review focuses on the fundamental understanding of carbohydrate-based drug delivery systems, strategies for application, and the evaluation of biological activity. Future perspectives, including opportunities and challenges in this field, are also discussed.

介绍

聚合物是由大分子组成的物质，其结构由多个重复单元组成。由于聚合物包含各种官能团，因此可以将它们与其他高分子和低分子量材料混合在一起，以赋予独特的功能特性，与某些药物结合，并可以针对任何应用定制。与其他聚合物类似，碳水化合物具有许多活性基。碳水化合物的一般公式为c_x(H₂o）_y，具有羰基，醛或酮。当单糖溶解在溶液中时，它们以吡喃糖或呋喃糖的形式存在，并获得了一个不对称的中心，称为“异体碳”。异晶碳上的羟基形成与羟基的α-/β-configuration中多糖或聚糖链形成糖苷键。同时，可以进一步修改其他位点的胺和/或羟基，以获得理想的物理和化学特性。如上图所示，作为天然大分子和生物活性物质，碳水化合物在聚合物药物输送系统中起着非常重要的作用。这篇综述将重点介绍用于药物输送的基于碳水化合物和碳水化合物修饰的聚合物系统。它将特别关注靶向聚合物的制备，这是通过碳水化合物修饰聚合物的合成方法，并将材料应用于药物输送系统中。

Download the full research paper as PDF:Carbohydrates Used in Polymeric Systems for Drug Delivery From Structures to Applications

或者read the article here

在本文中分析的碳水化合物为其药物递送申请：Starch,Cyclodextrins,Xanthan gum,Gellan gum,Pullulan,Chitosan

Di, x;梁,x;沈,c;裴,y;吴,b;他,Z. Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications.药物2022,14, 739. https://doi.org/10.3390/pharmaceutics14040739