乳液超临界流体提取微纳米颗粒形成的药物应用

Micro-/nanoparticle formulations containing drugs with or without various biocompatible excipients are widely used in the pharmaceutical field to improve the physicochemical and clinical properties of the final drug product. Among the various micro-/nanoparticle production technologies, emulsion-based particle formation is the most widely used because of its unique advantages such as uniform generation of spherical small particles and higher encapsulation efficiency (EE).

For this emulsion-based micro-/nanoparticle technology, one of the most important factors is the extraction efficiency associated with the fast removal of the organic solvent. In consideration of this, a technology called supercritical fluid extraction of emulsions (SFEE) that uses the unique mass transfer mechanism and solvent power of a supercritical fluid (SCF) has been proposed to overcome the shortcomings of several conventional technologies such as solvent evaporation, extraction, and spray drying. This review article presents the main aspects of SFEE technology for the preparation of micro-/nanoparticles by focusing on its pharmaceutical applications, which have been organized and classified according to several types of drug delivery systems and active pharmaceutical ingredients. It was definitely confirmed that SFEE can be applied in a variety of drugs from water-soluble to poorly water-soluble.

此外，与常规的微颗粒技术相比，它具有诸如低有机溶剂残留，高EE，高EE，理想的释放控制，更好的粒度控制以及通过有效且快速溶剂去除的聚集预防。因此，当相关领域的研究人员希望选择适当的制造工艺来制备所需的微型/纳米颗粒药物输送系统时，这项审查将是确定SFEE获得更好药物质量的适用性的良好资源。

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Article information: Park, H.; Kim, J.-S.; Kim, S.; Ha, E.-S.; Kim, M.-S.; Hwang, S.-J. Pharmaceutical Applications of Supercritical Fluid Extraction of Emulsions for Micro-/Nanoparticle Formation.药物2021,13, 1928. https://doi.org/10.3390/pharmaceutics13111928