造形器-药厂前接收器

电影编程系统送药

Philippe语言 — 2021年6月24日05:30:19+00

Film-forming formulations represent a novel form of sustained release dermatic products.用于皮肤液化或半固化编程通过皮肤挥发溶剂蒸发,配方内含聚合物组成固膜各种胶片配方测试水阻和压强并比对传统半固化配方渗透渗透研究显示半转基因治疗系统有潜在实用性可替代补丁系统以切题方式管理各种药物并持续发布特征。

下载整篇文章: >Film-Forming系统提供脱热药 /Lunter DJFilm-Forming Systems for Dermal Drug Delivery. Pharmaceutics 2021, 13, 932.https://doi.org/10.3390/pharmaceutics13070932

Polymers for use in film-forming formulations

Polymer	Properties
Carbopol (polyacrylat)	water-soluble, pH sensitive
Chitosan (Poly-D-Glucosamin)	water-soluble at pH < 7
Crosslinked polymer layer XPL	adhesive, elastic
Dermacryl 79 (Carboxylates Acrylpolymer)	water-insoluble

Ethylcellulose	non-toxic, not irritating, anti-allergic
Eudragit NE (ethylacrylate methylmethacrylate copolymer)	water-insoluble, transparent, elastic, adhesive
Eudragit RL-100 (polymethacrylate polymere)	water-insoluble, transparent, elastic, adhesive
Eudragit RS-100 (polymethacrylate polymere)	water-insoluble, transparent, elastic, adhesive
Eudragit L30D-55 (methacrylate-ethylacrylate-copolymer)	water dispersible at pH 2–3
Hydroxypropyl-beta-cyclodextrin	water-insoluble, increases bioavailability
Hydroxypropylmethylcellulose (HPMC)	water-soluble, non-ionic
KIucel (Hydroxypropyl cellulose)	water-soluble, non-ionic
Macrogol	water-soluble
Methyl cellulose	water-soluble
Poloxamer (polyethylenepolypropylene glycol)	thermoreversible
Plastoid (Butyl methacrylate-methylmethacrylate copolymer)	water-insoluble
Polydimethylsiloxane (PDMS)	water-insoluble, non-toxic
Polyvinyl alcohol (PVA)	water-soluble, adhesive, non-toxic
Polyvinyl pyrrolidine (PVP)	water-soluble, adhesive, increase bioavailability
Quaternary polymethacrylat (QPM)	water-insoluble
Sepineo P600 (acrylamide/sodium acryloldimethyltaurate)	water-insoluble
Silicone	water-soluble, non-occlusive

Conclusions and Further Prospects

According to previous research findings, film-forming systems have proven to be suitable for use as a delivery form due to their high substantivity and cosmetic attractiveness.药能从系统渗透到皮肤上,使皮肤和转基因药物应用成为可能配方还起仓库作用,持续释放薄膜喷雾在伤口护理领域已经建立并被病人广泛接受,而薄膜编程系统仍然是治疗疾病的例外。成片系统尚未能建立成治标法以对抗补丁等其他转基因系统光素LamisilOnce喷雾等胶片制作法研究慢性皮肤疾病时,尚没有配方供病人使用,既非可口可乐形式日常治疗,非可口可乐配方开发慢性炎性皮肤病和点染配方法可在未来更大力地实施。 Film成型法直接喷射皮肤产生二次皮肤感知,不同于补丁分分系统精确应用和 dosing使用补丁更容易实现,这些补丁也能保护处理过的皮肤面积并显示提高物理稳定性胶片仿真还含有亲脂相,因此也可用于干皮肤区由于其半固态性能,Gels的优势在于更容易和精确应用所有系统都完全适合个性化理疗半固态和液态配方可按单个集成制片,电影可逐个打印。在此背景中,胶片仿冒器可能比胶片造模系统更重要,因为胶片喷雾迄今为止主要建立起来,更容易应用。这些配方可用于慢性发炎皮肤病,除弱排出活性成分和高基分量外,对皮肤特性有正效果。skin-form-form-systems-dermal-form-servation/

三维平板打印-一种对临床即时配方和个性化医学的潜在方法

汤姆 — Frii,2021年6月18日5:30:51+00

The oral route is the most common form of drug administration, being a safe and convenient, particularly for solid oral dosage forms.当前大规模制造技术大都产生固定剂量单元并允许有限选择用量强在某些情况下,需要用药强度个性化化,包括髓治疗指数药或伴生药药药-药性/药效药-药性交互作用、酶或运输器药性变异性,以及特殊人群,包括老年人、儿童和肾功能缺陷/肝功能缺陷患者a类='btnbn-defaultbn-md'hrefs.com/wp-content/uploads/2021/06/this-print-a-aproach-to-Dose个性化可以通过复合或使用其他管理路径实现(例如侧接式),但这些路径缺少与标准制造相同的质量控制水平,不便/可接受性差不等。自动制造个性化固口化强力可解决这一需求开发三维打印自动逐层生成自定义平板三维打印片片子除单点使用外,还有可能用于早期临床试验期间的剂量升级、制片点药短期和制作复杂多药片片件并配有个人化配方图解特别是阻塞沉积建模(FDM),它涉及通过窄热喷嘴并随后沉积准备固态物体而分解热塑丝,似乎对临床现场生产有帮助,因为制造过程没有松散粉末,后处理可以避免。FDM应用需要FDM处理线程由热熔扩展制造。

IR是口服量表最常用发布剖面图,并同时产生来自通过热熔流程制造三维打印片片的固有特性的重大挑战工作旨在为从FDM-和直接粉打印中产生的独特值建议创建选项,这些方面与标准制造过程基本不同(即分散化制作和定制平板结构)。临界质量属性(CQAs)集成为3D打印片片片的成功标准,包括内容一致性提供剂量精度(相对标准一致性数据偏差)、权重一致性(以确保内容一致性)、分解剖面貌(目标快速释放)和物理化学稳定性此外,还考虑了开发三维打印剂量表的可接受外观和大小。

关键目标之一是开发一个工业化配方工具箱,适合不同的API开发可缩热熔挤出配方并装有多种药量首项研究探索选定前接收者组合实现快速或极快从FDM打印片状带水益模型复合所选水溶聚合物和水分分解/处理辅助工具对FDM兼容性的影响,并结合填充密度对配方质量属性的影响(即重量和内容一致性、分解率)进行了研究。Hypray-Cellose SSL选择为水益聚合物和咖啡因,药载量5-20%热稳定模型药Poly-Serveridone-vilenegletate聚合物(

在第三次研究中开发出易溶性模型复合立即释放FDM表,并使用非损性精确形态分析检测出分解关键结构参数基本methacrylate共聚物(

虽然FDM打印可能有利于临床现场制造,因为打印过程没有粉末或溶剂参与,但一大挑战是如何实现丝状所需机械性能允许FDM处理第四次研究探索直接粉色3D打印平板片,省略了简化引信沉积建模的丝片步骤直接三维打印时,粉状混合装入像盒头并成功打印出蜂窝设计跨步DPP内装孔度高表面积证明概念制作快速释放用量表水溶性HPCSSL选择矩阵前和咖啡因模拟药PEG4000增塑原型和KollidonQVA64快速分解聚合物对DPP可处理性和解析率的影响得到了调查3D打印低密度(30%)显示快速分解与配方无关,而高填密度(80%)则需要PEG4000和KollidonVA64组合实现快速释放所得平板显示药含量百分比完全一致,但有可变权重咖啡因以晶状状态和稳定多态形式出现直接粉末打印可行性即时释放用量表制作这种方法可创造避免热熔溢出的机会,允许三维打印独立于线性机械特性并有可能通过减热延长产品架存存存存期。

开发表板时对成人和儿童的尺寸都满足一致性内容需求,以提供精度剂量(相对标准一致性数据偏差)、权重一致性、分解目标(快速释放)和物理化学稳定性运算学研究表明,未来开发IR3D打印剂量表,除适当聚合矩阵选择外,还可以减少闭口孔量,增加开孔量,优化形状/大小和分解之间的平衡水益聚合矩阵与CAD设计相结合,通过FDM或DPP制造,对未来3D打印药产品开发大有希望然而,仍应克服的挑战包括直径整齐化丝状物、精度和可复制沉积质量、设计密度和实际密度差异、可预测最终形态学和丝状机械性能In addition, there might be a need in a real-time monitoring of flow and viscosity of the molten mass during the 3D-printing process.

Download the full dissertation as a PDF here

Author: Marina Fanous, Basel University.

Der Beitrag Three-dimensional printing of tablets – a potential approach to on-clinical-site extemporaneous formulation and personalized medicine erschien zuerst auf Pharma Excipients.

纳米基补丁供热传异构酸

汤姆 — 元2021年2月22日10点30分47+00

Photo-aging is caused mainly by sun radiations, which consist mainly of the ultraviolet radiation (UVA and UVB).cobic酸(AA)在整形场被广泛使用,作为一种反纹理、抗胃药剂和抗氧化物药剂,然而,其整形应用有限,原因是皮肤渗透率低、快速氧化化和配方不稳定。

本项研究的目的是用纳米模化策略交付AA并稳定化80 mg/mlA入水内油(O/W)纳米并定性为小滴大小、zeta潜力、热动稳定性和形态学hrefs/www.pharmaexsubjects.com/?sssss=sort&ids#sqflictssssAA纳米反射平均小滴大小14.4+1.9Nm,zeta潜力接近零。

a纳米反射物理稳定显示离散测试和加热/冷凝测试后无相位分离或扰动性遍历Strat-MQ+mbrane的AA累积量为602.2++57.9mg/cmsup2 ex渗透剖面图显示AA受控释放剖面图24H释放配对Higuchi模型相关系数为0.995Nanoemulsion-based patches could serve a potential system for the dermal delivery of unstable hydrophilic compound.

Read the article here

Article information: Ahlam Zaid Alkilani, Rania Hamed, Ghaid Hussein & Sabreen Alnadi (2021) Nanoemulsion-based patch for the dermal delivery of ascorbic acid, Journal of Dispersion Science and Technology, DOI:10.1080/01932691.2021.1880924

Der Beitrag Nanoemulsion-based patch for the dermal delivery of ascorbic acid erschien zuerst auf Pharma Excipients.

调查各种塑胶机对Kollicoat++++++30D基础大衣特性的影响

汤姆 — 弗里2020年12月25日06:30:48+00

INTRODUCTION

Plasticiser play a decisive role in the application of functional films, especially, if an aqueous dispersion containing a water insoluble polymer is used.水解持续释放薄膜组成聚合PVAC, 分拆延长和最小薄膜形成温度都强烈依赖编译配方中所用整形器类型和量MFFT可比低PVAC(18摄氏度)这一物理特征无关紧要[1]延时特性非常重要,特别是如果覆盖粒子压缩为多单元粒子系统This investigation is intended to consider the suitability of three different plasticiser: poly(ethylene glycol) 6000, 1,2-propylene glycol and triethyl citrate.

MATERIALS AND METHODS

Materials:

Poly(vinyl acetate) (Kollicoat® SR 30 D, BASF SE, Germany) was used in combination with the following plasticisers:

a) Poly(ethylene glycol) (PEG) 6000 (Lutrol® E 6000, BASF)
b) 1,2-Propylene glycol (PG) (Propylene glycol pharma, BASF)
c) Triethyl citrate (TEC) (Merck)

Formulations

The isolated films were prepared with a plasticiser content of 10% (m/m) each, calculated on the polymer content of the dispersion.为确保PVAC分布和整合均匀性,混合作用至少2小时。

准备单片

单片使用装有300微米刀的胶片放映器(CoatmasterErichsen测试设备)制作胶片投影器允许各种温度擦干胶片。

Character化单片

确定机械性能时使用纹理分析器(TA-XT2iHR,稳定微系统)。测试条件受气候控制23摄氏度和54%r.h[2]

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Der Beitrag Investigating the influence of various plasticiser on the properties of Kollicoat® SR 30 D based coats erschien zuerst auf Pharma Excipients.

QbD基础Eudragit涂层MeclizineHCl即时扩展多段使用HPLCFlues

Philippe语言 — wed, 16Serve2020 2.3016+00

This study is based on the QbD development of extended-release (ER) extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic evaluation with immediate-release (IR) pellets.HPLC流水法开发并验证用于等离子体药物分析IR药芯编译使用水作为颗粒液三级三因子CCRD应用模拟优化研究 Eudragit (RL100-RS100)、TEC和Talc对释放毒品和覆盖粒子广度的影响HPLC流水法敏感LLOQ1纳克/毫升和线性10至200纳克/毫升R2>0.99药效参数通过非剖析获取,结果用对数转换数据统计比较,p>0.05被认为无关紧要,CI限值90%为0.8-1.25ER粒子AUC0-t和AUC0+IR粒子群数(98.051纳克/毫升)高于ER粒子群数(84.052纳克/毫升)和ER粒子群数(5116 h)高于IR粒子群数(3.029h)。ER粒子关键药代物学参数未见重大食品效果Eudragit RL100(6%)覆盖Meclizine HCl潜在治疗效果延长 pdf.#bd基础Eudragit立即扩展多段发布 /pqstragets.com/wp-content/uploads/2020/09/QbD-coate-Meclizine-HCl-ext-reet al.ahrfs/www.nature.com/artics/s41598-020-71751y目标sSciRep10,14765(2020年)。https://doi.org/10.1038/s41598-020-71751-y

Excipients
Microcrystalline Cellulose, MCC (Avicel PH-101), Lactose monohydrate, Polyvinylpyrrolidone (PVP, MW ~ 44,000), Talc, Pentanesulphonic, and Heptanesulphonic acid salts, Eudragit RL100 and RS100

Der Beitrag QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates: formulation, characterization and pharmacokinetic evaluation using HPLC‑Fluorescence detection method erschien zuerst auf Pharma Excipients.

电影编译系统切换式提供药

Philippe语言 — 元,2020年8月31日17:25+00

Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression.alginic酸作为平板配方前台使用有限,因为有某些缺陷,如低平板硬度和低压缩性这项工作的目标是提高这些特性,具体化通用于增强表单前接收器功能的化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工化工工工工工工工工工工工化工工工化工化工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工工总体说来,提高甲基化程度产生拉伸强度更高和压缩性更好的片片改代数显示延长分解时间,与引进疏水性后原生alginica最后,用微晶素纤维素和晶素来编译变异变异分解和填充/绑定试剂的功能多功能性测试href="https/www.scient.com/science/pii/S188087171538目标ss'blank'rels'胶片编译凝胶使用量对臂膀、肩膀、大腿内部或腹部生成薄生物沉积薄膜药物溶入胶片编织器中,并嵌入薄膜皮肤中胶片可起外部水库作用或限制向皮肤提供药物从而控制释放药Various gelling agents are listed in the following table (based on "Film forming systems for topical and transdermal drug delivery")

Gelling agent	Properties
Gellan gum	•Anionic polysaccharide •Gel properties depend on the presence of alts •Excellent biocompatibility and degrades into non toxic products
Carbomer (Carbopol®) Grades – ETD 2020, 171, 910, 934, 934P, 940, 1342 NF, 1971P	•Excellent gelling efficiency in low concentrations of 0.25% to 1.5% •pH dependent gelling •Forms clear gel in water
Carboxymethyl cellulose	•Effective in concentrations of 4 to 6%. •Stable between pH 2 and 10 •Incompatible with ethanol
HPMC (E series, F series, K4M, K15M, K100M)	•Effective in concentrations of 2–6% as gelling agent •Produces a smooth, clear spreadable gel
Hydroxy ethyl cellulose	•Effective in concentration of 0.5–1% •Has thickening and stabilizing properties
Poloxamer (polyethylene–polypropylene glycol co-polymer) Grades – 124, 182, 188, 407	•Used in the concentrations of 20–30 % •Thermoreversible gelation-liquid at refrigerated conditions and gel at room temperature
Sepineo P 600 (acrylamide/sodium acryloyldimethyltaurate copolymer)	•Concentration of 0.5–5% used as gelling agent •It has thickening properties in aqueous or organic media over a wide pH range

Film Forming Polymers

Polymers are the foundation of the FFS and a variety of polymers are available for the preparation of these systems.实现所期望的胶片属性,这些聚合物可单独使用或与其他胶片组聚聚合物 ss/sciencedent.com/science/article/pii/S18808617301538#bb0215聚合物在皮肤温度下应形成清晰柔软膜The list of polymers along with their molecular weight and properties are mentioned in this table (based on "Film forming systems for topical and transdermal drug delivery")

Polymer	Properties
Hydroxypropyl Methylcellulose (HPMC) HPMC (E4M, E15, E50M K4M)	• Produce a light, non-greasy uniform film with good texture • Do not interact significantly with other ingredients • Surface active agent, therefore adsorbs water providing easy dispersion, lubricity and comfort feel in occlusive state on application to skin
Ethyl cellulose (EC)	• Nontoxic, nonirritating, nonallergic material • Good film forming properties that form tougher films
Hydroxypropyl cellulose	• Nonionic, pH insensitive polymer • Water soluble
Polyvinyl pyrrolidine (PVP)(PVP K30, PVP VA64	• Solubility in water and other solvents • Adhesive and binding property • Acts as a bioavailability enhancer
Polyvinyl alcohol (PVA)	• Water soluble • Excellent film forming and adhesive properties • Nontoxic and biocompatible
Chitosan	• Excellent film forming ability • Opens the tight junctions of mucosal membrane, thereby enhancing the paracellular permeability and penetration of drug • Controls drug release
Eudragit (polymethacrylates copolymer) Eudragit RS 100, RL 100, NE, RS 30D, S 100	• Transparent, elastic, self-adhesive • Good adhesion to the skin
Silicones Polydimethylsiloxane (PDMS)	• Water vapor permeable film • Adequate substantivity and durable film
Acrylates copolymer Avalure® AC 118, AC 120	• Tough, breathable, abrasion resistant films

Der Beitrag Film forming systems for topical and transdermal drug delivery erschien zuerst auf Pharma Excipients.

原位编译双受控释放二叉叉丁和ibrofen用于子膜炎处理:微生物和机械密钥特性

Markuskobel — Tue, 2020年8月18日12:30:27+00

In-situ forming implants (ISFI) which simultaneously release an antimicrobial and anti-inflammatory drug in a controlled manner offer an interesting potential for local periodontitis treatment.在这次研究中,对多片-单片/单片/单片/单片酸(PLGA)加载氯西丁和ibrofenPLGA(RG502H)解构eclittylips/dow-pharma-sublips/'gets='##blank' rels=#norefernernoferrer>>>Methocel ,E50使用agar-well扩散测试、时间技巧学习和生长曲线法研究抗微生物病原体液态配方和机械键性 stitive 编译器使用纹理分析器调查商业上可用胶处理局部二联二联二和二联二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二合二受调查ISFI显示对所有选择病原体快速强抗菌活动,同时保持适配机械性能science/abs/pii/S177327212454目标Agossa, A.Delepierre, M.Lizambard, E.Delcourt-Debruyne, J.Siepmann, F.Siepmann, C.spanQspan类名>Neutbr/spanJournal提供科技60卷,2020年12月,101956br/

使用先进药法制造固定剂量组合产品处理心血管疾病和二类糖尿病

Philippe语言 — 4月21日 2020年5月30日 17+00

Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin

The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination (FDC) products for the treatment of type II diabetes mellitus and cardiovascular diseases (CVDs).FDC产品单片和双片发布剖面片成功制作,方法包括喷雾干燥(SD)、热熔扩展(HME)、熔粒粒子化(MG)和喷出MonticFDC产品Hanthiazide和Rapipril立即发布剖面HME和SD都使用同样的配方与内存相关挑战之一是它是一个热解API并开始在熔化时下降约115摄氏度的相对低点添加适当的塑胶机(PEG3350)成功消除HME期间所见内存退化问题并选择IR聚合物(KollidoneVA64和Soluplos所有自定义配方完全无变后处理,HME配方部分晶状一般来说,非态材料显示高溶性高分解率比晶状材料高分解率当相应的SD和HME配方压缩到Wood机件并分解率所研究的两个API时,发现部分晶状HME配方显示比相关配方中相应的无变自定义配方高分解率聚合物大增,从含有Soluplu压缩木件盘表情研究显示HME配方比SD盘大为粗糙。

两种制造技术都成功生产IR单片FDC产品,比较研究则强调选择适当制造技术制作最终理想产品特征并避免API退化的重要性。

MonticFDC分析并研究影响制造技术以及液片素聚合物对最终产品特征的影响MG和SD都使用同样的配方由于MET用量大,处理前接收者的数量必须保持在最小值内选择两个HPC聚合物以配方,这些配方在分子权值和水氧代换程度方面各异。聚合物特性不同导致帽特征差异,而不管制造技术如何,突出聚合物成份对生产最终产品供病人消费的作用最终产品通过两种技术并使用聚合物制造,但只有一种产品由MG制作并压缩为8000N通过IR口服板所有常见计算测试工作突出显示MG生产高剂量组合产品的适当技术,它可能比SD更合适,原因很多。第一,人们认为它对环境更为友好,因为不需要溶剂。第二,MG过程生成的粒子比SD生成的粉末有更好的可流性第三,MG和SD可被视为连续制造技术,因为输入源源不变输出,SD粉末必须在采集容器内收集并去除后再进一步处理,而MG产品可直接注入下一阶段处理工作还突出显示,对权/粒子应用足够的压缩制成适合向病人交付的最终产品。

/p>a延迟释放配方simvastatin处理配方组件,如塑胶剂富集度、药加载量和聚合物比影响SIM发布剖面核心SIM配方制作后,exruate割入粒子并分解成球粒子涂层各种聚合物和溶剂以及不同的处理参数都经过测试,直到成功应用HCTZ和RAM理想量实现完成的工作突出显示使用HME制造核心材料的可能性,再用FBD生成并涂层核心材料由于涂层弹性化,不同富集度的不同药加载很容易实现。

a持续释放APIglicazide通过操纵配方组件,如聚合物比、增塑器选择和pH修饰物,实现理想释放剖面图,同时确保API热退化最小化工作亮点,热降解是HME进程期间API热性产品退化的一个重要因素,局部不良pH水平也可导致API退化GLZ核心配方制造后,exruate切割成粒子并分解成球粒子涂层Pharmacoat#603选择聚合物帮助SIT涂层核心材料,因为其成片特征各种溶剂组成过程在涂层过程中试用核心材料涂层数量也各不相同,大量核心材料提供更高的涂层效率,因为有较高的表面积可供涂层使用。工作强调通过HME生成持续释放热解API的可能性s.

应用附加API突出显示多种现代连续制造法可适用于FDC产品制作免溶方法如MG和HME可能比较有利,因为人们视之为一种“绿化式”技术,由于不使用严酷溶剂,环境效果更好热拉API通过MG和HME制造可能比较困难,但论文中的工作显示正确接收者并选择条件,通过这些方法生产产品是可能的。While solvent methods such as SD and SC may be seen as less favourable production techniques, they still have a vital role in developing formulations with desirable characteristics and release profiles.
Download the thesis here: The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the treatment of cardiovascular disease and type II diabetes

Der Beitrag The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the treatment of cardiovascular disease and type II diabetes erschien zuerst auf Pharma Excipients.

分解辅助词对Loratidine预制造PVAFD3D插件使用FDMFFFFF

汤姆 — Tue2020年3月17日10:30:37+00

Low drug loading efficiency is the limiting factor in the use of pre-fabricated filaments for 3D printing of pharmaceuticals.本研究的目的是修改预编织丝片的物质属性,将适当的溶解辅助工具合并以提高药加效率。

Lloatadine通过使用溶增器装入pVA丝片处理线条特征为形态和直径变化、药物内容、FTIR和热特性并打印成适维片片印刷片片段还定性为药检和放药结果表明,不同药用线程面变得粗糙,直径几乎不变,这些线程保留可打印性。

然而,经处理的线程内容增加7至24倍,特别是预处理甘油并浸透含Solupl印刷片片片还显示近似药物成像前缀分解和释放在大多数配方中都遵循扩散机制The study concludes that the treatment of PVA filament with solubilizer aids has significantly improved drug loading without compromising the printability.

偏液解聚乙烯酒精聚变药配方过程:评价合适的塑胶

Philippe语言 — Tue, 2020年2月11日

The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes.

Specifically, the effect of mannitol (MAN), sorbitol (SOR), sucrose (SUC), anhydrous citric acid (CA), triethyl citrate (TEC) and low-molecular weight polyethylene glycol (PEG400) on PVA's melting properties, physical state and thermal degradation was evaluated via differential scanning calorimetry (DSC), powder X-ray diffractometry (pXRD) and thermo-gravimetric analysis (TGA).

Results showed that the use of MAN, SOR, SUC and PEG400 led to the reduction of PVA's melting onset temperature, while MAN, SUC, CA and SOR were amorphously dispersed within PVA's matrix, and the addition of SUC and CA resulted in significant reduction of PVA's crystallinity.TGA结果显示CA和TEC案例热高度不稳定PVA混合物的形成(分别从++150oC和++125oC开始降解),FTIR发现PVA-MAN、PVA-SOR和PVA-SUC案例的重大分子交互作用最后,MD模拟与实验观察完全一致,表示可视之为有希望的系统理论建模工具。Continue on Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes

Der Beitrag Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes: evaluation of suitable plasticizers erschien zuerst auf Pharma Excipients.

准备并评价包含depezil的口服分解薄膜以治疗阿尔茨海默

Philippe语言 — wed,2019年10月16日 09:23:27+00

The present study intended to prepare orally disintegrating film (ODF) containing donepezil (DP) for the treatment of mild to moderate alzheimer disease.

HPMC and HPC, glycerine were used as film forming agents, plasticizer, respectively.ODFs使用溶剂铸法制作方法优化时用全因子设计计数胶片构件量、HPPC比例:HPC增塑素量独立变量和抗拉强度、延展性、折叠耐用度和分解时间依存变量并进行了机械化放药和优化DP-加载ODF配方生物可用性研究。

优化ODF配方和营销方对cmax、tmax和AUC0-t.ahrfs/www.scient.com/science/service/S1773224719383目标s

多进程分析器可应用性研究

Philippe语言 — Thu,2019年2月14日06:45:38+00

Process analytical technology (PAT) has become an important factor in design, analysis and control of complex technological processes.本研究用四种PAT方法监测pelet 进程,即近红外光谱学、拉曼光谱学、线内图像分析以及空间滤波技术。在研究第一部分实验级主动成份涂层过程期间,对新线内图像分析器的异常性与精度进行了研究。

模型质量测试批量研究最后一部分广泛调查了两种不同的拉曼进程分析器实时水分含量和涂层量测定的适用性光谱数据与线内SFT测量相关联.

此外,多变量模型标定方法可大大减少时间、成本和努力,以在制药行业实施PATContinue on PAT for pellets coating proceses or see als o the information on Eyecon PAT tool

Der Beitrag A Study on the Applicability of Multiple Process Analysers in the Production of Coated Pellets erschien zuerst auf Pharma Excipients.

当前前创科学动态-产品开发中每个前创量化选择

Philippe语言 — Thu, 24I2019 13:43:16+00

Implication of Quantitative Selection of Each Excipient in Product Development

Excipients' role in designing different dosage forms does not require any introduction.以上这些添加物与药理活性物质并发增加这些特性的主要目的是增加大片配方并传递期望属性始发者像药物一样,需要验证和标准化下一章简单介绍不同用量表使用前接收者,包括固态用量表、液态用量表和半固态用量表计药先进配方领域的持续开发,我们还覆盖纳米化前接收者。

aContinue the book chapter on excipients or check excipients basics.

Der Beitrag Current Developments in Excipient Science – Implication of Quantitative Selection of Each Excipient in Product Development erschien zuerst auf Pharma Excipients.

药片涂层是什么第一部分-表

Philippe语言 — Mon,14J2019223514+00

There a many reasons for coating of different pharmaceutical products such as pellets, granules, capsules, powders and crystals.文章中,我们将集中处理片子 < 强>/强>.

.程序涂层平板本层厚度介于20至200米之间,或大约占平板初始权值的1%至9%As a reference, a human hair is usually around 100 μm thick, much like the typical thickness of an immediate release coating. Continue reading here to get more insights on:

Main reasons for coating tablets
The composition of a typical coating formula
Application of typical coating formulas
Recommendations regarding the core tablets

Access Excipient Database

Der Beitrag What are pharmaceutical film coatings?第一部分-表单 erschienzufta

非传统药和前接受者应用

Philippe语言 — Mon,14J2019下午2:03+00

During formulation development, there are cases when, serendipitously, drug or excipients play a different role than intended one or a dual role.非传统作用实例之一是药物起增塑作用聚合物API整形趋势可能优于热熔化扩展和胶片

某些聚合物可以在配方开发中发挥非传统作用或双重作用!experacant(pooxamer)可用作热熔化扩展的增塑剂,而Lauryl SulfateSudium可起平板配方润滑剂作用持续释放聚合物压缩属性可帮助配方科学家,因为它可单用或少用压缩辅助物编译直接压缩即发片或持续释放片片片表dow化学公司开发HME聚合物以满足HME应用低TgHPPC编译科学家需求,因为HPCC传统等级高得多并需要添加增塑器低压HPPCHME聚合物建议,低压缩压下它可能拥有更好压缩性研究是为了评价这些聚合物的压缩属性此外,还检查粉性拟用作干绑定器或直接压缩持续释放聚合物Based on the compaction and powder properties of these polymers, these polymers can be used for the potential application as a dry binder or a direct compression sustained release polymer in tablet formulations.

Download full dissertation here: etd-2018-9051-1.pdf

by Pinak Bharat Khatri

https://doi.org/doi:10.7282/t3-aace-3t29

School of Graduate Studies Electronic Theses and Dissertations

Rutgers, The State University of New Jersey

Der Beitrag Non-traditional application of drug and excipient erschien zuerst auf Pharma Excipients.