含有姜黄素，槲皮素，灵芝提取粉和益生菌的自纳乳化组合物，用于有效治疗链脲佐菌素诱导大鼠2型糖尿病
Liquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin were prepared by dissolving them in isotropic mixture ofLabrafil M1944CS®,Capmul MCM®,Tween-80®和TranscutolP®.. The prepared L-SNEDDS were solidified usingGanoderma lucidumextract, probiotics and Aerosil-200® using spray drying. These were further converted into pellets using extrusion-spheronization.
Highlights
Curcumin and quercetin loaded SD-S-SNEDDS pellets were formulated.
Ganoderma lucidummushroom extract and probiotics were used as solid carriers.
SNEDDS pellets showed enhanced dissolution rate and permeability of CUR and QUE.
SNEDDS pellets showed significant increase in oral bioavailability of CUR and QUE.
SNEDDS pellets showed excellent antidiabetic activity for CUR-QUE in diabetic rats.
The mean droplet size and zeta potential of L-SNEDDS were found to be 63.46 ± 2.12 nm and – 14.8 ± 3.11 mV while for solid SNEDDS pellets, these were 72.46 ± 2.16 nm and -38.7 ± 1.34 mV, respectively. The dissolution rate for curcumin and quercetin each was enhanced by 4.5 folds while permeability was enhanced by 5.28 folds (curcumin) and 3.35 folds (quercetin) when loaded into SNEDDS pellets. The Cmax for curcumin and quercetin containing SNEDDS pellets was found 532.34 ± 5.64 ng/mL and 4280 ± 65.67 ng/mL, respectively. This was 17.55 and 3.48 folds higher as compared to their naïve forms.
在将姜黄素和槲皮素中加载到鼻塞颗粒时，将在姜黄素和槲皮素的增加约50.23-和5.57倍。在加速储存条件下发现鼻涕颗粒稳定。与其Naïve形式相比，开发的制剂能够使胰腺癌诱导糖尿病大鼠胰腺和肝脏的血糖，血脂，抗氧化生物标志物和组织结构的水平正常化。
文章信息：Rubiya Khursheed，Sachin Kumar Singh，Bimlesh Kumar，Sheeu Wadhwa，Monica Gulati，Anupriya，Ankit Awasthi，Sukriti Vishwas，Zaskiran Kaur，Leander Corrie，K.r.Arya，Rajan Kumar，Niraj Kumar JHA，Piyush Kumar Gupta，Flavia Zacconi，Kamal Dua，Nitin Chitranshi，Gulam Mustafa，含有姜黄素，槲皮素，灵芝提取粉和益生菌的自纳外乳化组合物，用于有效治疗2型糖尿病在链霉菌杂菌素诱导大鼠的Mellitus，国际药学杂志，2021. https://doi.org/10.1016/j.ijpharm.2021.121306。