使用TWEEN 80跨度80作为乳化剂和HPMC作为胶凝剂的抗痤疮粘液(Achatina Fulica)抗痤疮emulcel的配方

抽象的

痤疮是皮肤异常的状况,由丙酸杆菌的细菌感染是由炎症引起的。可用于痤疮的医学治疗的天然一体是蜗牛粘液(Achatina fulica)。它具有抗菌活性的Achasin蛋白。蜗牛粘液是对肌电胶质形式的。该研究使用了实验方法和肌凝胶制剂使用各种浓度的乳化剂和胶凝剂。它们的吐温80 1.76%,2.44%,3.12%,跨度80 2.24%,4.06%,5.88%和HPMC 3.5%,4.5%,5.5%。其他添加剂是丙二醇,甲基羟苯甲酸甲基,丙基帕莱甲,石蜡液,薄荷醇和AQUAMEST。在室温下4周储存期间在物理评估中进行物理评估测试,刺激试验,啤酒次试验和循环试验。感官测试表明,肌电胶质是乳白色,具有独特的气味。所有Emulcel都是同源物,非刺激物,水中乳液式油(O / W)。 These emulgel also met the normal skin of pH value and spread ability’s range. The emulgel viscosity shift were < 10%, with the viscosity value inversely proportional to spread ability. Formula C with 3.12% of Tween 80, 5.88% of Span 80 and 5.5% of HPMC was claimed as the most stable formula both in room temperature and after cycling test. It was also the most preferred by panelist.

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