环糊精作为含有Polygoni Cuspidati提取物的粘膜粘附片的功能载体，其具有牙科应用的潜力
Polygoni Cuspidati.根部是富含白藜芦醇的富源，具有抗炎，血管生成和神经保护作用。原料是用于白藜芦醇的含量标准化，其中存在在口腔粘膜内给药特别理由。为了改善白藜芦醇的溶解度并确保其在植物材料中的高含量，施加超声辅助提取方法。
The addition of cyclodextrin was found to increase the extraction efficiency of resveratrol (from 13 to 297 µg per 1 g of plant material in case of 50% ethanol extracts) and enhanced its antioxidant activity as compared to purePolygoni Cuspidati.extract/resveratrol. Cyclodextrin plays the role of a functional extract regarding technological properties (increasing the extraction of resveratrol from the extract, improving mucoadhesive properties). Therefore, the aim of this study was to develop mucoadhesive tablets containing combinations of thePolygoni Cuspidati.用环糊精载体提取用于颊递送。
该试验依次包括提取物的制剂和表征其物理和生物学性质，然后用广泛描述的原型性质的制剂研究。测试结果表明，环糊精增加了白藜芦醇提取的效率Polygoni Cuspidati.rhizome, which is a rich source of resveratrol, and its extract enclosed in a mucoadhesive tablet guarantees prolonged action at the site of administration.
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材料：植物原料，番茄囊状物和根源，购自Herbapol Cracow（克拉科夫，波兰）。从巨型Knotweed粉末提取物中分离的白藜芦醇（98％）（RSV）由PK组分（波兰，波兰）提供。大黄素通过Sigma-Aldrich（Poznań，波兰）获得。Pion Inc.（Billerica，Ma，USA）提供Prisma™HT缓冲区，受体水槽缓冲区和Git Lipid解决方案Carbopol®974NF聚合物由此获得Lubrizol（威斯利夫，哦，美国），而β-cyclodextrin那hydroxypropyl-β-cyclodextrin average Mw ~ 1460 (0.8–1.0 MS Molar Substitution) and(hydroxypropyl)methyl cellulose (HPMC)with average Mn ~ 90,000 (~15,000 cP) andmagnesium stearate由Sigma-Aldrich（Poznań，波兰）提供。使用以下来自Sigma-Aldrich（Poznań，波兰）的化学品：DMSO D4540，ACHE C3389，BCHE C7512，ATCHI A5751，BTCH B3128，DTNB D8130，DodePezil D6821，Neostigmine N2001，Magnifline SMB00377，Rivastigmine SML0881，Eserine E8375，Neocuproin N1501，CuCl2 307483，TPTZ 93285，Trolox 238813，荧光素46955，COF2 236128，亚油酸L1376，Tween 20P1379，β-胡萝卜素C9750，Tween 80抗坏血酸A92902 P1754,谷胱甘肽还原酶G3664, glutathione (GSH) G4251, glutathione peroxidase G6137, nicotinamide adenine dinucleotide phosphate (NADPH) N5130, ethylenediaminetetraacetic acid (EDTA) E9884, glutathione disulfide (GSSG) G4626, superoxide dismutase (SOD) S5395, nitrobluetrazolium N6639, xanthine X0626, xanthine oxidase X4875. 2,2′-Azobis(2-amidinopropane) dihydrochloride (AAPH) was from Acros Organics (401560250), cyclooxygenase-2 (COX-2, human recombinant, 60122) and COX-2 activity assay kit (760151) were from Cayman Chemicals (Ann Arbor, MI, USA). Buffer salts, solvents and other reagents were from Sigma Aldrich (Poznań, Poland) and were at least of analytical grade. HPLC grade acetonitrile was obtained byMerck(Warsaw, Poland). High-quality pure water and ultra-high-quality pure water were prepared by using a Direct-Q 3 UV Merck Millipore purification system. Buccal mucosa from the porcine cheek was obtained from Bost slaughterhouse (Turosn Koscielna, Poland). Samples excised immediately after animal death were washed and frozen at −20 °C in isotonic saline solution. Prior to experiments, tissue was defrosted at ambient temperature and cut into pieces.
文章信息：Paczkowska-Walendowska，M。Szymańska，e .;Winnicka，K .;szwajgier，d .;Baranowska-wójcik，e .;Ruchała，M.A ;;Simon，M .;Cielecka-piontek，J.Cycleodextrin作为含有粘膜粘附片的功能载体Polygoni Cuspidati.Extract with Potential for Dental Applications.Pharmaceutics2021.那13.那1916. https://doi.org/10.3390/pharmaceutics13111916