Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation.然而,这种自然油基配方还导致《生物多样性公约》吸收方面的巨大变异性工作用脂基配方并加中链三叉化物 [.]
Der Beitrag Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation.自然油基配方还导致吸收 or download the full research paper as pdf: Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol 秦市西波拉E李JB济嘉尔A珠YOrtori市股市MJ康斯坦丁斯库巴雷特地检官菲舍尔PMGershkovich P中信Triglyride inlipid制程帮助微信解析,但在Vivo性能保留纯Sesame油车优异性能。 药学 2021 , 13 ,1349https://doi.org/10.3390/pharmaceutics13091349 See also our 118金宝搏app
Der Beitrag Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle erschien zuerst auf Pharma Excipients.Materials
N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and biomedical fields.TMC应用为mcoadhesiveadivaft/citos-coate-nano-comles/
N-trimethyl chitosan (TMC) is a multifunctional polymer that can be used in various nanoparticle forms in the pharmaceutical, nutraceutical and biomedical fields.In this study, TMC was used as a mucoadhesive adjuvant to enhance the oral bioavailability and hence antitumor effects of gemcitabine formulated into nanocomplexes composed of poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) conjugated with d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) .
Highlights
Synthesized TMC modify the PLGA-TPGS nanocomplexes to enhance oral absorption.
The central composite design model was applied to obtain the optimal formulation.
The drug release mechanism is governed by anomalous diffusion.
TMC led cell uptake of particles by adsorptive and caveolae-mediated endocytosis.
The carrier greatly enhanced oral drug bioavailability and inhibited tumor growth.
A central composite design was applied to achieve the optimal formulation.细胞摄取和药物传输研究显示纳米复合渗透 通过吸附介介和洞穴介导内分解渗透肠细胞药效学研究显示,与药效解法相比,纳米复合体口服药生物利用率提高5.1倍。
数据显示TMC修改纳米复合物可增强宝石圈口服生物可用性并推广抗癌效果。
Der Beitrag N-trimethyl chitosan coated nano-complexes enhance the oral bioavailability and chemotherapeutic effects of gemcitabine erschien zuerst auf Pharma Excipients.
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has shown potential applications in cancer therapy owing to its attractive properties, including reversal of multi-drug resistance and synergistic effects with antitumor drugs.但其相关缺陷不可低估,包括激活人体免疫响应和加速多乙烯甘化制剂清血PSA [.]/p>
DerBeitrag D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has shown potential applications in cancer therapy owing to its attractive properties, including reversal of multi-drug resistance and synergistic effects with antitumor drugs.不可低估相关缺陷,包括激活人体免疫响应并加速多乙基配方的清血量。 polysiaclicePSA和TPGS并发性合成以削弱TPGS的免疫风险PSA-TPGS和TPGS自组装混合小鼠并封装经典抗白化毒理粒子填充混合小鼠尺寸为16.3+2.0Nm,绑定效率为99.0+0.9%,药载效率为3.20++0.03%抗扰活动研究表明混合小鼠比Tween80和TPGS小鼠有更好的肿瘤抑制作用。
To overcome cancer drug resistance and to reverse tumor immunosuppression, a vitamin E-tocopheryl polyethylene glycol succinate (TPGS) decorated polymer-based drug delivery system was developed.药方系统对细胞分解、癌症入侵、转移和免疫抑制所涉各种蛋白的影响得到了调查,以提供对TPGS修改药的更全面的理解 [.]
Der Beitrag To overcome cancer drug resistance and to reverse tumor immunosuppression, a vitamin E-tocopheryl polyethylene glycol succinate (TPGS) decorated polymer-based drug delivery system was developed.药服系统对细胞分解症、癌症入侵、转移和免疫抑制等各种蛋白的影响得到了调查,以提供对TPGS修改药服系统更全面的理解。Curcumin (CUR), a hydrophobic drug, was loaded in star poly(DL-lactide) with a cholic acid core, and then decorated with TPGS shell to obtain CUR@TPGS/star poly(DL-lactide) nanoparticles (CUR@TPNP). A TPGS decorated drug delivery system was constructed to overcome cancer drug resistance. The delivery system can reverse cancer drug resistance through down-regulating P-gp expression. The system efficiently downregulates cancer-promoting proteins to inhibit cancer progression. The downregulated PD-L1 indicates the delivery system can reverse cancer immunosuppression. This investigation provides a facile strategy to overcome cancer MDR and immunosuppression. Cholic acid cored star poly(DL-lactide) is featured by a rapid degradation rate with a surface erosion characteristic.TPGS不仅通过调低肿瘤细胞P-gp表达式来逆向肿瘤药物抗药性,而且还通过TPGS/CUR对由CD47和PD-L1介导的肿瘤免疫抑制反向综合治疗行动提高抗扰效率As compared with the CUR loaded nanoparticles without TPGS decoration, CUR@TPNP with TPGS decoration results in significantly enhanced intracellular drug accumulation to efficiently induce cell apoptosis in drug resistant tumor cells. More importantly, CUR@TPNP possesses considerably improved efficacy in upregulating p53 and p21 as well as downregulating β-catenin, MMP-9, Snail, CD47 and PD-L1, indicating the TPGS decorated drug delivery system inhibits tumor development and metastasis much more efficiently. Article information: Ying-Ying Guan, Shao-Qi Zeng, Yin Qin, Yan Mu, Hong Liu, Vitamin E-tocopheryl polyethylene glycol succinate decorated drug delivery system with synergistic antitumor effects to reverse drug resistance and immunosuppression, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021.https://doi.org/10.1016/j.colsurfa.20213187.spsl类et_bloom_bottriger
Highlights
Herein, a nano-micelle drug delivery system was developed to orally improved zingerone's bioavailability and its antitumor effect.并装D-A-Copheryl聚乙烯小鼠有效编译、定性和评估+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
Herein, a nano-micelle drug delivery system was developed to orally improved zingerone's bioavailability and its antitumor effect.zingerone-loaded
Article information: (2021) Improved oral bioavailability, cellular uptake and cytotoxic activity of zingerone via nano-micelles drug delivery system, Journal of Microencapsulation, DOI: 10.1080/02652048.2021.1957036
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Der Beitrag Improved oral bioavailability, cellular uptake and cytotoxic activity of zingerone via nano-micelles drug delivery system erschien zuerst auf Pharma Excipients.
Gastrointestinal (GI) disorders affect millions of people and are considered a major cause of global morbidity. Mosapride citrate (MOS) is a prokinetic agent with antiemetic effect.低溶性诱导生物利用率低本研究旨在通过配制快速释放片片提高该药在vivo的性能mosapride高亮点TSD [.]
Der Betrag
Gastrointestinal (GI) disorders affect millions of people and are considered a major cause of global morbidity. Mosapride citrate (MOS) is a prokinetic agent with antiemetic effect.低溶性诱导生物利用率低The present study aimed to enhance the in-vivo performance of the drug through formulation of fast release tablets.
Highlights
TSD of mosapride showed an enhancement in dissolution t1/2 = 1.5 min.
Tablet of mosapride with TSD showed 60.7% flush release with a t1/2 = 1.4 min.
An ultrasonographic study performed on rabbits revealed that TSD tablet showed 2.5 -fold increase in duodenal and cecal motility compared to marketed tablet.
Both binary (SD) and triple solid dispersion (TSD) were prepared with Soluplus® (SOL) and α-Tocopherol polyethylene glycol succinate (TPGs) using solvent evaporation.最优系统按最优分解率选择并压缩成片片,使用方法有:https://www.pharmaexccepties.com/orgic-化学s/cmc-croscarmellose-nau/ac-di-sd-711-whitepaper/结果显示MOS-TSD获取tsub>2 =1.5分钟的最高分解率。 DSC和XRPD展示了偏态mosaprideFTIR显示药运商间可能的H联系交互mostovidone药片解毒显示60.7%流水释放tsub>1/2 =1.4min.
快速发布板配制基于表面三重固化提供提高mosapride疗效的极大成功:
The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption.Gelucise48/16和TPGS混合小鼠配方提高分解率Curcumin散落于这些熔脂表面作用物中,这些表面作用物随后被载体吸附并编译成粒子 [.]
Beitrag
The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption.s/www.pharmaexsubjects.com/product/gelcire-48-16/曲曲宁散落于这些熔脂表面活性剂中,然后吸附到载波上,通过分解分解成粒子临界小鼠富集度
More about microcrystalline cellulose
Shinde, U.K., Suryawanshi, D.G.和Amin,P.DGelucire /sup>48/16和TPG混合Mielles及其用Excrien化技术编译解析率crubinhttps://doi.org/10.1208/s12249-021-02032-8
See also our short video on Vitamin E TPGS:
Der Beitrag Development of Gelucire® 48/16 and TPGS Mixed Micelles and Its Pellet Formulation by Extrusion Spheronization Technique for Dissolution Rate Enhancement of Curcumin erschien zuerst auf Pharma Excipients.
The present study evaluates the crystal growth rate of amorphous drugs when dispersed in different ternary polymeric amorphous solid dispersions (ASDs) in the presence of surfactants.具体地说,通过熔化算法冷却编译ssds矩阵/carriers三种常用ASDs矩阵/
The present study evaluates the crystal growth rate of amorphous drugs when dispersed in different ternary polymeric amorphous solid dispersions (ASDs) in the presence of surfactants.Specifically, ternary ASDs of aprepitant (APT, selected as a model drug) were prepared via melt-quench cooling by evaluating three commonly used ASDs matrix/carriers, namely hydroxypropyl cellulose (HPC), poly(vinylpyrrolidone) (PVP) and the copolymer Soluplus® (SOL), and two suitable surfactants, namely d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (P407).
Results showed that all components were completely miscible (verified via hot stage polarized microscopy) and both surfactants were acting as plasticizers to the API.APT晶增速在P407和TPGS同时提高,PVP被确定为最大效果API晶增速抑制矩阵/载波趣味地说,TPS与PVP合并产生可见协同效应,导致APT晶体增速进一步下降。
P>Percemore评价APT分解介质内核感应时间(PBSpH6.8)显示PVP为最有效晶化抑制器,而TPS加法显示提高PVP抑制APT内晶化能力Finally, the formation of intermolecular interactions in the ternary APT-PVP-TPGS provided an explanation for the observed PVP-TPGS synergistic effects, with molecular dynamics simulations being able to unravel the type and extent of these interactions on a theoretical basis.Download the full article as a PDF here or read it here
Materials: APT (mixture of form I and II, Jubilant Generics Limited, Karnataka, India) was kindly given as a gift from Rontis Hellas S.A.(雅典,希腊)Graft copolymer Soluplus® (SOL), PVP (Kollidon®K12), TPGS (Kolliphor®TPGS, TPGS) and Poloxamer 407 (P407, Kolliphor® 407) were obtained from BASF (Ludwigshafen, Germany).HPC-SL从Shin-Etsu获取(日本南加市)。所有其他试剂均具有分析级或药级并按实收使用 。
form信息:Africtia Kapourani, Theodora Tzakri,Vasiliki Valkanioti,KonstantiKontogiannopoulos.Panagiotisbembalexis永态固态分布药晶生长:表面作用物和聚合矩阵载波效果,国际药理学杂志:X卷32021https://doi.org/10.1016/j.ijpx.2021.100086.
Der Beitrag Drug crystal growth in ternary amorphous solid dispersions: Effect of surfactants and polymeric matrix-carriers erschien zuerst auf Pharma Excipients.
To reduce the dosage size of amorphous solid dispersion (ASD)-based formulations, it is of interest to devise formulation strategies that allow increased drug loading (DL) without compromising dissolution performance.研究的目的是探索表面加法如何影响药物释放,视之从晚期ASD载药函数 [.]
Der Beitrag To reduce the dosage size of amorphous solid dispersion (ASD)-based formulations, it is of interest to devise formulation strategies that allow increased drug loading (DL) without compromising dissolution performance.研究的目的是探索表面加法如何影响药物释放从永恒ACD+函数。 本研究支持在asd配方中添加冲动词,作为增加dl而无损发布策略exploring-the-Role-for-Surfactants-in-Afrapous-Drug-Rele巴帕特P摩森 DE克斯图尔 美国Taylor L.S.探索悬浮剂作用增强高药加载非定固分解药量。 药理 2021 , 13 735https://doi.org/10.3390/pharmatutics130535
Abstract: Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy.产生各种副作用Sal极大限制应用上表生长因子受体家庭在大多数乳腺癌细胞中表现优异受体家庭GE11显示优异EGFR相似性[.]
Beitrag
Abstract:
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy.产生各种副作用Sal极大限制应用上表生长因子受体家庭在大多数乳腺癌细胞中表现优异受体家庭GE11显示优异EGFR相似性合成了一系列纳米粒子衍生物GE11编译PLGA/TPGS南极降水法用于准备Sal加载纳米粒子优化富集特征描述、目标定位效果和抗扰活动均检测到 invitro 和 ivo 约50%的乳腺癌病人最终引起肿瘤复发和/或转移,妨碍持久有效治疗。
Salistomiccin(Sal)切除药盐水溶性差和非大规模癌症细胞细胞毒性直接交付乳腺癌细胞将是一个宝贵的突破。标注纳米粒子开发成优秀药服系统,因为它们有希望性能和独特性,例如提高药不可应用性或药代特性。 此外,由于增强渗透性保留效果,静脉药可能在固态肿瘤网站积聚,从而产生临床增益并减少副作用。 生物可降解聚合物和生物兼容液类是纳米医学中常用的类别。液态是球状脂载体单层或多层并优于可行表面修改和长流时间ivo 编译液受不可控制释放毒品、不稳定性以及药装量不足的限制聚合滑动混合纳米粒子组合可以消除限制,但一些研究人员开发纳米粒子,将其作为强药提供系统处理癌症PLGA多语法co-glyclice酸特征是长效药物从多日释放到多周并简单配方多种方法,如表面仿真法、小说合成法和多词法In addition, PLGA shows advanced biocompatibility in vivo with a rigid structure. TPGS, D-α-Tocopheryl polyethylene glycol 1000 succinate, is a water-soluble derivative of natural vitamin E which can be used as solvent, stabilizer, and emulsifier for PLGA modification. These modifications can cause the size of PLGA nanoparticles be smaller and the drug encapsulation efficiency be higher. Moreover, both the PLGA and TPGS are approved by US food and drug administration (FDA) as safe pharmaceutical excipients. Some researchers have used PLGA/TPGS particles to deliver drugs for improving chemotherapy about multi-drug resistant breast cancer.
Epidermal growth factor receptor (EGFR) is greatly overexpressed on the surface of various human malignancies and regarding as a valuable target for cancer therapy include breast cancer. A screened small peptide GE11 by the phage display was demonstrated to have high affinity against EGFR significantly upregulated cancer cells. The affinity between GE11 and EGFR is significantly high (kd = 22 nM).GE11 has only 12 amino acids (YHWYGYTPQNVI) and is much smaller than the EFGR's ligand EGF. This small peptide targets only to one region of EGFR.s加载纳米粒子应用GE11定位peptide实现向乳腺癌细胞高效交付als-sal-GE11通过绑定反EGFRpitide与NP-Sal并用阳极反应进一步编译s-NPs-GE11对乳癌细胞的物理化学特征描述、目标效果和抗波活动在这次工作中得到了评价。
Der Beitrag GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells erschien zuerst auf Pharma Excipients.
Chrysin (CHR), a flavone found in multiple vegetables, fruits and mushrooms has been explored so far as a neurotropic, anti-inflammatory and anti-cancer biomolecule.低溶性生物用量限制其治疗益为了避免这些缺陷,本调查报告Chrysin唇片开发CLPs开发 [.]
DerBeitrag Chrysin (CHR), a flavone found in multiple vegetables, fruits and mushrooms has been explored so far as a neurotropic, anti-inflammatory and anti-cancer biomolecule.低溶性生物用量限制其治疗益为了避免这些缺陷,本调查报告Chrysin脂质开发。
Der Beitrag Electrostatic deposition assisted preparation, characterization and evaluation of chrysin liposomes for breast cancer treatment erschien zuerst auf Pharma Excipients.
Multidrug resistance (MDR) remains the primary issue leading to the failure of chemotherapy.在这次研究中,为定向交付axel处理MDR癌症搭建了d-a-toco开发出一种脂态纳米系统来治疗多药抗癌sulfate推介ss/tps-chordroitin-sulfates/
Multidrug resistance (MDR) remains the primary issue leading to the failure of chemotherapy.In this study, a d-α-tocopherol polyethylene 1000 glycol succinate (TPGS) and chondroitin sulfate (CS) dual-modified lipid-albumin nanosystem was constructed for targeted delivery of paclitaxel (PTX) in treating MDR cancer.
Highlights
A lipid-albumin nanosystem was developed to treat multidrug resistance cancer.
Introduction of chondroitin sulfate promoted CD44-mediated endocytosis.
TAL/PTX@CS showed notable antitumor efficacy and good biosafety.
The obtained nanosystem (TLA/PTX@CS) had an average size of around 176 nm and a negative zeta potential of around −18 mV.TPGS确认改善PTX细胞内积聚并便利脂性单片反射纳米系统外CS外壳功能化TLA/PTX@CS通过CD44受体中位内分解输入MDR乳腺癌CS shell was degraded by concentrated hyaluronidase in the lysosomes, thereby releasing PTX into cytoplasm and inhibiting cell proliferation. In vivo studies revealed that TLA/PTX@CS possessed prolonged blood circulation, resulting in elevated tumor accumulation, excellent antitumor efficacy with a tumor inhibition ratio of 75.3%, and significant survival benefit in MCF-7/MDR tumor-bearing mice.
Hence, this TPGS and CS dual-modified lipid-albumin nanosystem provides a promising strategy for targeted delivery of chemotherapeutic drug and reversal of MDR in cancer treatment.
Article information: Kaipei Luo, Feng Xu, Tianyi Yao, Jianping Zhu, Hua Yu, Guangji Wang, Juan Li.TPGS和chondroitinulfate双变脂单纳米系统定向交付抗多药抗癌药剂,国际生物宏素杂志,第183卷,2021年https://doi.org/10.1016/j.ijbiomac.2021.05.070.
Der Beitrag TPGS and chondroitin sulfate dual-modified lipid-albumin nanosystem for targeted delivery of chemotherapeutic agent against multidrug-resistant cancer erschien zuerst auf Pharma Excipients.
This study aimed to investigate the role of micellization of sodium lauryl sulfate (SLS) in poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using the anti-solvent method in enhancing the dissolution rate of practically water-insoluble cilostazol (CLT).sLS输入CLT加载SDs,权比50:10CLT、POX和SLS
This study aimed to investigate the role of micellization of sodium lauryl sulfate (SLS) in poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using the anti-solvent method in enhancing the dissolution rate of practically water-insoluble cilostazol (CLT).SLS嵌入CLT加载SDs中,权比50:50:10CLT、POX和SLS使用三种不同方法:反溶解、聚变(60°C)和溶剂蒸发反溶液法中含有小鼠SLSssss的Sdds变换偏态优。
值得注意的是,通过非相联化和小鼠SLS吸附POX基SD矩阵中聚合链区和疏水区之间存在疏水交互反溶解法SLS小分解有效中断并受解解CLT约束,CLT禁止药粒聚合和内吸,提高SD可湿性(低接触角)并降低粒子大小和分解速率。
使用防溶液法将临界小鼠富集成SD解析结果显示,使用防溶法预加法小鼠SLS解析POXS有限公司RamatHovav,IsraSLS从Sigma-Aldrich购买Hyproproymecellose (HPMC.6cps)汉城Poloxamer 407, polyvinylpyrrolidone K30 (PVP K30), D-α-tocopherol polyethylene glycol 1000 succinate (TPGS), and soluplus were supplied by BASF Chemicals (Ludwigshafen, Germany).聚乙烯glycol6000(PEG6000)取自Yakuri纯化物公司(日本东京)。所有其他化学品都具有分析等级,使用时不作进一步的净化 。formation信息:JinGNgo H.V.曲JH王J公园C李BJ悬浮微分解作用使用pooxamer 407基固分解https://doi.org/10.3390/pharmatutics13050662
Polymers consisting of amino acid building blocks continue to receive consideration for biomedical applications.聚氨酸用自然氨酸建构,同块蛋白制成,生物兼容性,生物可分解性,降解产物可代谢性amino酸显示一种独有AB2结构,这方便了自身能力 [...]
BeitragPolymers consisting of amino acid building blocks continue to receive consideration for biomedical applications.聚氨酸用自然氨酸建构,同块蛋白制成,生物兼容性,生物可分解性,降解产物可代谢性aminoa酸显示独有非对称AB2结构,方便编组分支结构的能力。
本审查比较三种高度分支聚合结构:结构高度组织化drimers、drifts他们的合成得到审查和比较,综合调制方法得到考虑并显示传统合成的变异性讨论高度分支聚合物在生物医学应用领域的潜在使用问题,具体地说,这些聚合物作为传基因药工具的应用问题,以及它们作为抗病毒复合物的使用问题20种基本氨酸中,L-液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化液化考虑药送系统时,这些高度分支聚合物小对交付可吸入药有利高分支聚合物, 特别是drimers, 已被研究40多年提供基因和药, 但没有大规模翻译到诊所中,除非有希望的反病毒应用已经商业化。
/a/ahrefs='https/www.mdpi.com/2079-911/51119'点击这里! article信息:ThompsonM舒尔兹市高度分治聚合物基于多片生物医学应用。 Nano材料 2021 , 11 1119https://doi.org/10.3390/nano11051119Der Beitrag Highly Branched Polymers Based on Poly(amino acid)s for Biomedical Application erschien zuerst auf Pharma Excipients.
Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of adult patients with active psoriatic arthritis.Aprimilist低溶性限制它分解和生物可用性arefs/www.pharmaexsubjects.com/Pharma
Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of adult patients with active psoriatic arthritis.Aprimilast 低溶性限制分解和生物使用研究开发APST固散d-a-tocoX-RPD、差分扫描卡路里和Fleier变红外线分光测量用法描述固差特征,结果显示APST固差变异性 。 Invitro 分解研究表明磷酸缓冲saline固差分解率显著提高,在10分钟内释放90%
Moreover, ivo C max 和AUC Last 分别比APST表B高近22倍和12.9倍APST固散TPGS和PVA是一个替代药提供系统,提高APST溶性和口服生物可用性。 ahref='https://link.springer.com/article/10.1208/s12249-021-x'目标shttps://doi.org/10.1208/s12249-021-02005-xMore about Vitamin E TPGS:
Der Beitrag Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and Bioavailability erschien zuerst auf Pharma Excipients.